Abstract: An optical device includes: a first substrate; a second substrate on the first substrate; multiple optical sensing modules on the first substrate, the multiple optical sensing modules including a first group of optical sensing modules and a second group of optical sensing modules; and a controller electrically connected to the multiple optical sensing modules. When the controller detects a user, the controller sends control signals to drive the first group of optical sensing modules and the second group of optical sensing modules simultaneously to perform a measurement on the user, and obtains a first physiological signal of the user and a second physiological signal of the user simultaneously.

Abstract: Provided herein are devices and systems comprising a light source which provides a beam to an optical module via a multimode fiber, an interference objective module outputs the beam processed by the optical module and collects interference signals from a sample; and a detector which detects the interference signals from the interference objective module wherein the optical module comprises an etendue squeezing component configured to slice the beams to at least two sub-beams and homogenize the sub-beams to an illumination field and match the shapes of the illumination field with the region of interest.

Abstract: A method for examining skin tissue of a subject based upon in vivo skin imaging includes a harmonic generation microscopy (HGM) device. The HGM device is configured for observing the skin tissue and forming sectioned images of the skin tissue of second harmonic generation (SHG), third harmonic generation (THG), or combination of the SHG and the THG of an excitation light scanning the skin tissue. The method further includes a step to determine whether the morphological feature of the skin tissue is related to a skin disease.

Abstract: The present invention provides a plural third harmonic generation (THG) microscopic system and method. The system includes a laser device, a microscopic device, a beam splitter device and a photodetective device. By utilizing lasers with different central wavelengths or a broad band light source to simultaneously analyze THG response with respect to different wavelengths, a plurality of THG images and THG spectrum of the material or bio-tissue under stimulation of different wavelengths are obtained, thereby retrieving distributed microscopic images and resonant characteristics of the observational material or bio-molecules.

Abstract: The present invention provides a plural third harmonic generation (THG) microscopic system and method. The system includes a laser device, a microscopic device, a beam splitter device and a photodetective device. By utilizing lasers with different central wavelengths or a broad band light source to simultaneously analyze THG response with respect to different wavelengths, a plurality of THG images and THG spectrum of the material or bio-tissue under stimulation of different wavelengths are obtained, thereby retrieving distributed microscopic images and resonant characteristics of the observational material or bio-molecules.