Abstract: A box underframe end structure of a railway vehicle includes an underframe boundary beam, an end beam, a front draft sill, and a coupler mounting seat, and further includes a rear end cross beam located on one side in a rear of the front draft sill, an end floor fixed between the end beam and the rear end cross beam, and a coupler cross beam fixed with the coupler mounting seat into a whole. A draft sill includes the front draft sill and a rear draft sill respectively arranged on a front side and a rear side of the coupler mounting seat. The coupler cross beam, the rear end cross beam, and the end floor are welded and fixed with the underframe boundary beam. The front draft sill, the rear draft sill, and the coupler cross beam are welded and fixed on a lower surface of the end floor.

Abstract: A display substrate and a manufacturing method therefor, and a display device are provided. The display substrate includes a drive circuit layer disposed on a substrate, the drive circuit layer includes a plurality of circuit units, at least one circuit unit includes a pixel drive circuit, a first power supply line providing a power supply signal to the pixel drive circuit, a data signal line providing a data signal to the pixel drive circuit, and a data fan-out line connected with the data signal line; at least a portion of the first power supply line, the data signal line, and the data fan-out line extends along a second direction and is arranged at intervals along a first direction, at least a portion of the data fan-out line is disposed between the first power supply line and the data signal line, the first direction intersects with the second direction.

Abstract: There are provided systems and methods for a multi-layer cache to prevent user experience interrupts during feature flag management. A service provider may provide applications to computing devices of users including mobile applications. Use and availability of features in an application may be configured using feature flags, however, change of these feature flags may initiate an application refresh that affects user experiences with the application. To prevent interruptions, a multi-layer data cache may be used where feature flag data for the feature flags may initially be loaded, after a time period, to a first layer cache that is not used to update the application. When conditions exist for updating the application without affecting the user experience, such as if the user is no longer using a workflow, the feature flag data may be loaded to a second layer cache. The second layer cache may then be used for updating.

Abstract: The disclosure provides a chain-link converter, comprising: a first node; a second node; and a plurality of switch submodules, wherein the plurality of switch submodules are connected in series, and the plurality of switch submodules are electrically connected between the first node and the second node, and a switching time of at least one switch submodule is greater than the switching time of other switch submodules. The chain-link converter of the disclosure effectively suppresses the common-mode current by extending the switching time of at least one switch submodule.

Abstract: The present invention provides novel methods for immobilizing and/or optically mapping oligonucleotides, the method comprising immobilizing the oligonucleotides on a micropatterned substrate. In another aspect, the invention provides a method for mapping a genome, wherein the method is capable of resolving a single nucleotide polymorphism (SNP), the method comprising introducing to the genome a CRISPR/Cas9 system comprising at least one single-guide RNA (sgRNA) specific for a target sequence or a plurality of target sequences across the genome and a Cas9 D10A, wherein the CRISPR/Cas9 system nick labels the target sequence, and the target sequence or genome is analyzed.

Abstract: A diode includes a semiconductor region having at least one two-dimensional carrier channel of a first conductivity type, the first conductivity type being one of a n-type and a p-type conductivity, the at least one two-dimensional channel having a net charge; a material of a second conductivity type, the second conductivity type being the other of the n-type and the p-type conductivity, disposed on the semiconductor region, the material of the second conductivity type having a net-charge in a depletion region that is substantially equal to the net-charge of the at least one two-dimensional channel in the semiconductor region when the diode is under reverse bias; an anode material in contact with at least a portion of the at least one two-dimensional channel and at least a portion of the material of the second conductivity type; and a cathode material in contact with the at least one two-dimensional carrier channel.

Abstract: Described herein is a method of categorizing a cancer (such as into TEL+ cancer or ALT+ cancer). The method includes performing a global analysis of telomere lengths in cancer cells of the cancer, and determining the category of the cancer based on patterns of telomere lengths. Also described herein is a method of treating cancer based on the categorizing of the cancer.

Abstract: The invention provides microfluidics devices, methods and kits employing expandable gels in a sample chamber for translocating cells or particles in a sample solution to an observation plane to facilitate counting and analysis.

Abstract: Disclosed herein is a photonic material for reducing transmission of ultraviolet light. The photonic material has spherical scatterers in a matrix material. The spherical scatterers have an amorphous arrangement in the matrix material and are configured to scatter ultraviolet light traveling in the matrix material. The amorphous arrangement of the spherical scatterers causes multiple scattering of the ultraviolet light. Absorbing material is disposed within the matrix material or the spherical scatterers and absorbs the ultraviolet light traveling in the matrix material.

Abstract: Disclosed is a movable foundation static load test apparatus, which includes a rack, a crawler traveling mechanism and a position adjusting mechanism. The rack is configured to place a balancing weight, the crawler traveling mechanism includes a frame fixedly connected with the rack and is configured to drive the rack to travel, the position adjusting mechanism has a movable stroke moving along the vertical direction, the rack has a movable stroke moving along the vertical direction, the position adjusting mechanism is configured to adjust the distance between the rack and a test object. The crawler traveling mechanism drives the rack to travel, after reaching a test point, the distance between the rack and the test object is adjusted by the position adjusting mechanism to carry out a static load test, the rack may be conveniently moved through the crawler traveling mechanism.

Abstract: In one aspect, the invention provides universal multi-color mapping strategy in nanochannels combining conventional sequence-motif labeling system with Cas9 mediated target-specific labeling of any 20-base sequences (20mers) to create custom labels and detect new features. The sequence-motifs are labeled with green fluorophores and the 20mers are labeled with red fluorophores. Using this strategy, it is not only possible to detect the (structural variants) SVs but it is also possible to utilize custom labels to interrogate the features not accessible to motif-labeling, locate breakpoints and precisely estimate copy numbers of genomic repeats. In another aspect, the invention provides CRISPR-Cas9 enabled whole-genome sequencing.

Abstract: In various embodiments, the present invention is directed to a supraparticle for use in producing structural colors comprising a plurality of core/shell nanoparticles having a melanin or synthetic melanin core and a silica shell having a plurality of silanol groups on its outer surface and a poly(ethylene glycol) (PEG) crosslinker. In various embodiments, the structure of these crosslinked supra particles is reinforced by hydrogen bonds formed between the silanol groups on the core-shell nanoparticles and mechanical, solution phase, and dry state stability.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for controlling an agent interacting with an environment. In one aspect, a method comprises: receiving a natural language text sequence that characterizes a task to be performed by the agent in the environment; generating an encoded representation of the natural language text sequence; and at each of a plurality of time steps: obtaining an observation image characterizing a state of the environment at the time step; processing the observation image to generate an encoded representation of the observation image; generating a sequence of input tokens; processing the sequence of input tokens to generate a policy output that defines an action to be performed by the agent in response to the observation image; selecting an action to be performed by the agent using the policy output; and causing the agent to perform the selected action.

Abstract: A film including a polymer matrix with a first refractive index, a component with a second refractive index embedded in the polymer matrix in a disordered arrangement, wherein the second refractive index is different from the first refractive index, wherein the film scatters 400 to 500 nm wavelengths of light and allows transmission of wavelengths of light from 600 to 800 nm.

Abstract: A device may include a substrate of a first conductivity type, the first conductivity type being one of a n-type conductivity and a p-type conductivity, the substrate having a base surface. A device may include a first terminal coupled with the base surface of the substrate, a first semiconductor region disposed over the substrate, the substrate positioned between the first semiconductor region and the first terminal, the first semiconductor region including a top surface, which defines a plurality of trenches having sidewalls, the plurality of trenches separated by a plurality of pillars, the first semiconductor region formed of a first material with the first conductivity type, a second semiconductor region disposed over the sidewalls of the first semiconductor region to form a superjunction with the first semiconductor region, the second semiconductor region formed of a second material different from the first material and having a second conductivity type.

Abstract: An intelligent yarn loading system and a control method are provided. The intelligent yarn loading system comprises a twisting machine, a self-walking trolley and a dispatching control system; the twisting machine is provided with a twisting machine wireless communication module for sending a working state of the twisting machine to the dispatching control system; the self-walking trolley is provided with a trolley wireless controller and a self-walking device for receiving an instruction of the dispatching control system and walking to a station of the twisting machine to take off an empty bobbin, and put a basic yarn on a creel of the twisting machine or take off a finished product package for stacking.

Abstract: There are provided systems and methods for a multi-layer cache to prevent user experience interrupts during feature flag management. A service provider may provide applications to computing devices of users including mobile applications. Use and availability of features in an application may be configured using feature flags, however, change of these feature flags may initiate an application refresh that affects user experiences with the application. To prevent interruptions, a multi-layer data cache may be used where feature flag data for the feature flags may initially be loaded, after a time period, to a first layer cache that is not used to update the application. When conditions exist for updating the application without affecting the user experience, such as if the user is no longer using a workflow, the feature flag data may be loaded to a second layer cache. The second layer cache may then be used for updating.

Abstract: An automatic yarn feeding system is provided. The system comprises a yarn feeding track which is arranged on the twisting machine in a length direction of the twisting machine and provided with a yarn feeding manipulator walking along the yarn feeding track; and a supply zone which is arranged on one side of the yarn feeding track and used to buffer base yarns. The yarn feeding manipulator is used to convey the base yarns from the supply zone to a yarn feeding creel of each spindle position. The yarn feeding track is located in the middle of the top of the twisting machine. The supply zone is provided with a structure for buffering a plurality of base yarns, and is located on one side of an end of the yarn feeding track on the top of a control cabinet.

Abstract: A semiconductor device includes a semiconductor region having at least one two-dimensional carrier channel of a first conductivity type, the first conductivity type being one of a n-type and a p-type conductivity, the at least one two-dimensional channel having a net charge, the semiconductor region including a first semiconductor region coupled with a drain terminal and a second semiconductor region coupled with a source terminal; and a third semiconductor region of a second conductivity type electrically coupled with a gate terminal, having a gate region and a net charge region, the net charge region disposed over the first semiconductor region and having a net charge in a depletion region that is substantially equal to the net charge of the at least one two-dimensional channel in the first semiconductor region when the semiconductor device is in an off-state.

Abstract: This disclosure provides semiconductor device including a first transistor with a first gate terminal, a first source terminal, and the first drain terminal, the first transistor being a depletion mode transistor and including a plurality of two-dimensional carrier channels of a conductivity type being one of a n-type or a p-type conductivity. The semiconductor device also includes a second transistor with a second gate terminal, a second source terminal, and a second drain terminal, the second transistor being an enhancement mode transistor, a gate-source interconnect forming an electrical connection between the first gate terminal and the second source terminal, and a drain-source interconnect forming an electrical connection between the first source terminal and the second drain terminal. The first transistor and the second transistor are fabricated on the same wafer or substrate.