Abstract: A scheduling method and system for the operation of reservoirs to recharge freshwater for repelling saltwater intrusion under changing conditions. Research data of a research area is collected, the research area is generalized, and the river network topology of the area is constructed; the research data acquire the seawater flow data of each station in the research area for N time periods, analyze the correlation between the flow of a predetermined station and the saltwater intrusion and build a seawater flow spatial-temporal evolution model; rainfall data and freshwater runoff of each station are acquired to analyze the variation trends of freshwater flow and hydrological regime of each station and a first ending point and build a freshwater flow spatial-temporal evolution model; and a scheduling model for recharging freshwater for repelling saltwater intrusion is built for simulation, a scheduling method is provided, and a scheduling scheme set is formed.

Abstract: The present invention discloses a Acinetobacter baumannii immunogenic protein and its composition and application. This invention provides a protein, comprising 39 amino acids of the N-terminal ?-helix part of the Ata protein transport functional domain of Acinetobacter baumannii and an adjuvant protein; amino acid sequence of said 39 amino acids of the N-terminal ?-helix part of the Ata protein transport functional domain of Acinetobacter baumannii is shown as the 127th-165th amino acid residues of SEQ ID NO:2. In present invention the 39 amino acids of the N-terminal ?-helix part of surface protein Ata (Acinetobacter trimeric autotransporter) of Acinetobacter baumannii, was took to fuse with CTB, and express in BL21. The protein was purified by a nickel column, and used to intraperitoneally immunize mouses by 2.5 ?g/mouse. Its immunogenicity and immunoprotection was verified through the animal experiments, which proves it has a good effect of anti-infection of Acinetobacter baumannii.

Abstract: An isolated cell membrane potential detection system can measure a cell membrane current change when light having different parameters such as wavelength, energy density, pulse width, and repetition rate stimulates a cell to be detected, to detect whether the biological electrical activity of the cell can be regulated by light, and to detect the specificity of the light regulation parameters of the cell. In the light regulation cell membrane potential detection system, a method of progressively adjusting and detecting with multiple optical parameters from small to large is used to measure a cell membrane current change in different periods under a certain photostimulation parameter for each group of cells, so as to quickly and efficiently detect which type of optical signal can regulate the characteristics of the cell such as the generation of a membrane current, photostimulation parameter specificity, and an energy threshold.

Abstract: Disclosed are a data sharing method, a network side device, a system, an electronic device, and a storage medium. The method includes: creating a sandbox for a data provider, and synchronizing information on the sandbox to a second network side device, wherein the sandbox is bound to an original database, and the information on the sandbox includes metadata of the original database; receiving a sandbox access request initiated by a data application party and forwarded by the second network side device, wherein the sandbox access request carries metadata of request data; collecting, in the original database bound to the sandbox, original data queried on the basis of the metadata of the request data; and generating response data to the sandbox access request according to the collected original data, and notifying, by means of the second network side device, the data application party to acquire the response data from the sandbox.

Abstract: Provided herein are new devices for indicating the status of events, such as the number of relevant events that are remaining and/or that have already occurred up to the present moment and to related devices, systems, and methods. In some aspects, the event-related indicator devices of the invention are used within larger dispensing devices or systems, e.g., to provide the status of administration of a substance contained therein (e.g., a drug). In an exemplary embodiment, the indicator devices find particular utility within medicament dispensers, such as metered dose inhalers, to provide a visual indication of the status of doses having been or remaining to be administered.

Abstract: The invention discloses a self-adaptive hanging structure of a converter, including vertical connecting rod mechanisms connecting the lower edge of a backing ring body and a lower half converter body of the converter, and horizontal connecting rod mechanisms connecting the upper edge of the backing ring body and an upper half converter body of the converter; the horizontal connecting rod mechanisms are located above the vertical connecting rod mechanisms, the plane where the axis of a trunnion on the backing ring body and the axis of the backing ring body are located serves as the first reference plane, the symmetric center of each vertical connecting rod mechanisms is located in the radiation area of the first included angle, the two planes forming the first included angle coincide with the axis of the backing ring body, and the included angles being 15 degrees and 50 degrees are formed between the two planes and the first reference plane respectively.

Abstract: Provided is a semiconductor structure. The semiconductor structure includes a substrate including a die region and a non-die region, wherein an accommodation recess is formed in a side of the substrate and positioned in the non-die region; a buffer disposed in the accommodation recess; a functional film layer disposed on the side, where the accommodation recess is formed, of the substrate; and a passivation layer covering the functional film layer and the substrate. A buffer cavity with an opening facing away from the substrate is formed in the buffer. An orthographic projection of the functional film layer on the substrate is within the die region. A first through-via is formed in the passivation layer. An orthographic projection of the first through-via on the substrate is at least partially overlapped with an orthographic projection of the opening on the substrate. The opening is in communication with the first through-via.

Abstract: This disclosure relates to antibodies, antigen-binding fragments, protein constructs, and chimeric antigen receptors that bind to a complex comprising an AFP peptide and an MHC molecule, and the uses thereof.

Abstract: An isolated cell membrane potential detection system can measure a cell membrane current change when light having different parameters such as wavelength, energy density, pulse width, and repetition rate stimulates a cell to be detected, to detect whether the biological electrical activity of the cell can be regulated by light, and to detect the specificity of the light regulation parameters of the cell. In the light regulation cell membrane potential detection system, a method of progressively adjusting and detecting with multiple optical parameters from small to large is used to measure a cell membrane current change in different periods under a certain photostimulation parameter for each group of cells, so as to quickly and efficiently detect which type of optical signal can regulate the characteristics of the cell such as the generation of a membrane current, photostimulation parameter specificity, and an energy threshold.

Abstract: A scheduling method and system for the operation of reservoirs to recharge freshwater for repelling saltwater intrusion under changing conditions. Research data of a research area is collected, the research area is generalized, and the river network topology of the area is constructed; the research data acquire the seawater flow data of each station in the research area for N time periods, analyze the correlation between the flow of a predetermined station and the saltwater intrusion and build a seawater flow spatial-temporal evolution model; rainfall data and freshwater runoff of each station are acquired to analyze the variation trends of freshwater flow and hydrological regime of each station and a first ending point and build a freshwater flow spatial-temporal evolution model; and a scheduling model for recharging freshwater for repelling saltwater intrusion is built for simulation, a scheduling method is provided, and a scheduling scheme set is formed.

Abstract: The present application provides modified immune cells expressing a mutant IL-15 polypeptide. In some embodiments, the modified immune cell further comprises an engineered receptor such as a chimeric antigen receptor (CAR). The present application also provides methods and pharmaceutical compositions for cancer treatment using the modified immune cells described herein.

Abstract: The present disclosure provides applicators adapted to or configured to deliver a product therefrom. The applicators can be particularly designed for delivery to certain body parts of the human body, such as to the vaginal area. The applicator can comprise a housing formed of a substantially continuous wall extending along a longitudinal housing axis between a base end and an application end, the substantially continuous wall defining: a base segment extending from the base end toward the applicator end; a delivery segment extending from the applicator end toward the base end; and a compression segment interconnecting the base segment and the delivery segment. The housing can define a substantially hollow interior configured for retaining a product for delivery through the delivery segment.

Abstract: Provided herein are new devices for indicating the status of events, such as the number of relevant events that are remaining and/or that have already occurred up to the present moment and to related devices, systems, and methods. In some aspects, the event-related indicator devices of the invention are used within larger dispensing devices or systems, e.g., to provide the status of administration of a substance contained therein (e.g., a drug). In an exemplary embodiment, the indicator devices find particular utility within medicament dispensers, such as metered dose inhalers, to provide a visual indication of the status of doses having been or remaining to be administered.

Abstract: A robot according to one or more embodiments may include an arm and a hand. The hand is connected to the arm and supports to convey a wafer. The hand includes a base end portion that is an end of the side connected to an arm, and a distal end portion that is an end of the opposite side of the base end portion. With the hand, a lightened part is formed in at least a part of a first region which is a region of a distal end portion than the center part in the longitudinal direction of the hand.

Abstract: Provided are engineered cells (such as stem cells or T cells) that have a surface molecule comprising a membrane-tethered binding moiety that binds to a T cell surface antigen (such as CCR5, CD4 or CXCR4) or a HIV antigen, or a membrane tethered inhibitory moiety that inhibits the membrane fusion of HIV (such as C34). Also provided are methods of making and using these engineered cells.

Abstract: An obtaining method and apparatus for a block group header, a storage medium, and an electronic device are disclosed. The method may include, performing a determination as to whether a target node in a blockchain system meets a preset condition, where the preset condition is indicative of at least one of, the target node receiving a block group header but failing to receive a preset number of legal blocks, or the target node failing to receive the block group header; identifying a cause of an event that the target node fails to receive the block group header, in response to the determination that the target node fails to receive the block group header, where the cause of the event comprises at least one of, the target node failing to receive the block group header, or the blockchain system failing to generate the block group header; and determining a method for acquiring by the target node, the block group header that fails to be received, according to the cause of the event.

Abstract: An engineered immune cell comprising a first functional exogenous receptor capable of binding and depleting natural killer (NK) cells, and a second functional exogenous receptor, wherein the engineered immune cell has reduced MHC I on cell surface.

Abstract: A method and system to facilitate the use of multiple voice services using a common voice interface on a hearable device, the common voice interface enabling multiple wake word detections to enable users to connect to and interact with a selected voice service.

Abstract: There is provided a dose counter assembly for use with a medicament dispenser, the dose counter assembly comprising: a) a units dose display means comprising a first count indicia and one or more driver teeth; b) a tens dose display means comprising a second count indicia; and c) a driver, wherein the first count indicia and second count indicia align at a common viewing area to collectively display a count sequence.

Abstract: A proxy method, a device, and a computer-readable storage medium are disclosed. The proxy method may include: obtaining transaction data of a user, the transaction data including a transaction request and private data; sending the transaction request to a blockchain platform, completing, by the blockchain platform, a transaction according to the transaction request, and storing the private data locally; and after the transaction is completed, sending the private data to a peer proxy for transaction verification.