Abstract: Provided herein are oligonucleotides, peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.

Abstract: A transformer-based neural network includes at least one mask attention network (MAN). The MAN computes an original attention data structure that expresses influence between pairs of data items in a sequence of data items. The MAN then modifies the original data structure by mask values in a mask data structure, to produce a modified attention data structure. Compared to the original attention data structure, the modified attention data structure better accounts for the influence of neighboring data items in the sequence of data items, given a particular data item under consideration. The mask data structure used by the MAN can have static and/or machine-trained mask values. In one implementation, the transformer-based neural network includes at least one MAN in combination with at least one other attention network that does not use a mask data structure, and at least one feed-forward neural network.

Abstract: The present invention disclosed a method for preparing a thickener for tight oil and gas reservoir, which relieves damages. The technical solution includes the following steps: putting a three-flask in ice; adding perfluoroalkyl alcohol, P-toluenesulfonyl chloride and pyridine; reacting for 3 h at 0-20° C.; adding filter paper; ultrasonic dispersing for 1 h; removing the filter paper; washing the solution for 3-5 times by adding dilute hydrochloric acid to collect the intermediate product (I); adding 1,3-dihydroxy-propane-2-tert-butyl carbamate and the intermediate product (I) in another three-flask; adding potassium carbonate and N,N-dimethylformamide; reacting for 4 h at 40° C. to collect the intermediate product (II); adding trifluoroacetic acid and methylene chloride into the intermediate product (II); reacting at 45° C. for 2 h; extracting and vacuum drying; and adding 1,6-hexamethylene diisocyanate; reacting for 2 h to collect the final product (III).

Abstract: This application relates to the field of communications technologies, and provides a mode switching method in a Wi-Fi network and a terminal device, to reduce power consumption of the terminal device while implementing a MIMO function. The method includes: After a terminal device accesses a Wi-Fi network, the terminal device communicates, in a multiple input multiple output MIMO mode, with an access point that provides an access service of the Wi-Fi network; the terminal device obtains first received signal strength and a first throughput of the Wi-Fi network in the MIMO mode; and when the first received signal strength is greater than a first strength threshold and the first throughput is less than a first throughput threshold, the terminal device switches from the MIMO mode to the single input single output SISO mode.

Abstract: A method for workflow organization can be provided to manage digital conversations. Provisions for such method may be implemented in a system configured for contextually organizing digital conversations and viewing associated content. For each user, a tree of conversations which is specific to the user is constructed, while preserving context shared between users. The workflow management preferably includes provisions for appointments and attachments.

Abstract: A power margin tracking control method and system for a multi-terminal high-voltage direct current converter station are provided. A power adjustment factor is introduced on the basis of a droop coefficient, to realize a self-adaptive regulation of a converter station operation mode to a real-time fluctuation of a wind and solar power. In this way, the system operation stability and the power fluctuation allocation capability in a grid-connected system are improved. Furthermore, a DC voltage deviation in the multi-terminal high-voltage direct current grid is reduced.

Abstract: Implementations of the present disclosure relate to text generation with a customizable style. In a method, a first natural language is received; the first natural language text is converted, via a text generation model, into a second natural language text that at least partly reflects the meaning of the first natural language text and has a style distinguishable from the first natural language text, the text generation model comprising a modifiable parameter; and in response to receiving a modification to the parameter, the first natural language text is converted, via the text generation model, into a third natural language text that at least partly reflects the meaning of the first natural language text and includes a style distinguishable from both the first natural language text and the second natural language text.

Abstract: In embodiments of the present disclosure, there is provided an approach for fact checking based on semantic graphs. According to embodiments of the present disclosure, after obtaining a text to be fact checked, a plurality of evidence sentences related to the text are retrieved from an evidence database. Then, semantic graphs of the text and the evidence sentences are constructed based on the semantic analysis, and a veracity of a statement in the text can be determined based on the semantic graphs. Embodiments of the present disclosure propose a graph-based reasoning approach for fact checking, and use the constructed semantic graphs to facilitate verification of the truthfulness of the text, thereby improving the accuracy for fact checking.

Abstract: Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3? and/or 5?-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.

Abstract: An interconnect structure includes a substrate, a dielectric layer on the substrate, a metal interconnect layer in the dielectric layer and in contact with the substrate, the metal interconnect layer having an upper surface flush with an upper surface of the dielectric layer, and a graphene layer on the metal interconnect layer. The graphene layer insulates a metal from air and prevents the metal from being oxidized by oxygen in the air, thereby increasing the queue time for the CMP process and the device reliability.

Abstract: A semiconductor device includes: a conductive layer; a plurality of nanopillars spaced apart from each other overlying the conductive layer, each nanopillar comprising a first semiconductor layer and a second semiconductor layer on the first semiconductor layer, the first semiconductor layer being different in conductivity type from the second semiconductor layer; and a graphene layer overlying the plurality of nanopillars, the graphene layer being connected to each of the plurality of nanopillars.

Abstract: The present disclosure provides a technical solution of multi-modal chatting, which may provide response to user query by using multi-modal response in the interaction between chatbot and human beings, so that the expressing ways and the expressed content by the chatbot could be richer by using such response in a multi-modal way.

Abstract: The present invention relates to a recombinant fusion protein comprising a fragment of the cardioprotective protein neuregulin-1 (NRG-1) fused to a monoclonal antibody (mAb) backbone and to a method of treating a disease or condition in a subject in need thereof comprising administering a therapeutically effective amount of the recombinant fusion protein or the pharmaceutical composition comprising the recombinant fusion protein disclosed herein.

Abstract: Method and system for training a text-to-content suggestion ML model include accessing a dataset containing unlabeled training data collected from an application, the unlabeled training data being collected under user privacy constraints, applying an ML model to the dataset to generate a pretrained embedding, and applying a supervised ML model to a labeled dataset to train the text-to-content suggestion ML model utilized by the application by utilizing the pretrained embedding generated by the supervised ML model.

Abstract: A method and system for providing an application-specific embedding for an entire text-to-content suggestions service is disclosed. The method includes accessing a dataset containing unlabeled training data collected from an application, the unlabeled training data being collected under user privacy constraints, applying an unsupervised ML model to the dataset to generate a pretrained embedding; and utilizing the pretrained embedding to train the text-to-content suggestion ML model utilized by the application.

Abstract: A camera assembly and a mobile terminal comprise an optical image stabilization motor with relatively large electromagnetic radiation, for example, a SMA motor. The SMA motor could be disposed on a lighting side of the lens assembly. Because an image sensor is located on an imaging side of the lens assembly, this can achieve a relatively long physical distance between the SMA motor and the image sensor, thereby reducing electromagnetic interference caused by the SMA motor to the image sensor.

Abstract: A Lactobacillus paracasei and uses thereof. The Lactobacillus paracasei has a deposit number of CGMCC No. 14813. The Lactobacillus paracasei can be used for increasing the amount of an organic acid in a raw material. The Lactobacillus paracasei can be used for fermenting the raw material, where the raw material can be selected from at least one of fruits, which can increase the content of the organic acid in a fermented product.

Abstract: In implementations of the subject matter described herein, a new approach for presenting a response to a message in a conversation is proposed. Generally speaking, in response to receiving a message in a conversation, the received message will be matched with one or more documents on the sentence basis. That is, the received message is compared with the sentences from a document(s), rather than predefined query-response pairs. In this way, a whole sentence may be selected from the document as a candidate response. Then the suitability of this sentence with respect to the ongoing conversation will be determined, and the response will be generated and rendered in an adaptive way based on the suitability. As a result, the user experiences may be significantly enhanced in the chatbot scenario.

Abstract: In accordance with implementations of the present disclosure, there is provided a solution for answering a question in a natural language conversation. In this solution, a question in a natural language conversation is received and converted into a logical representation corresponding to semantics of the question, the logical representation including a first sequence of actions executable on a knowledge base. An answer to the question is derived by executing the first sequence of actions on the knowledge base. This solution can accurately understand the semantics of a question in a multi-round conversation, so as to convert the questions into a sequence of actions executable on a large-scale knowledge base. In this way, the solution can effectively improve accuracy and efficiency of the natural language question answering system in question answering.

Abstract: A method of manufacturing a semiconductor device includes providing a substrate structure. The substrate structure includes a conductive layer and a plurality of nanopillars spaced apart from each other overlying the conductive layer. Each nanopillar includes a first semiconductor layer and a second semiconductor layer on the first semiconductor layer. The first semiconductor layer and the second semiconductor layer have different conductivity types. The method also includes forming a graphene layer overlying the plurality of nanopillars. The graphene layer is connected to each of the plurality of nanopillars.