Abstract: The present invention provides a 2-polysubstituted aromatic ring-pyrimidine derivative and an optical isomer thereof, or a pharmaceutically acceptable salt or solvate thereof, the compound, and an optical isomer thereof or a pharmaceutically thereof acceptable salts or solvates can be used in the preparation of anti-tumor drugs. The invention designs and synthesizes a series of novel small molecule Chk1 inhibitors by using N-substituted pyridin-2-aminopyrimidine obtained by structure-based virtual screening as a lead compound, and carries out Chk1 kinase inhibitory activity test. The experiment confirmed that said compounds possess potent anticancer activity, Chk1 kinase inhibitory activity, and are promising Chk1 inhibitors, and can be used as new cancer therapeutic drugs, which can be applied to treat solid tumors or hematologic tumors related to proliferative disease of human or animal.

Abstract: The present disclosure provides a visible light-transparent and radiative-cooling multilayer film, including N layers of films which have different thicknesses and are arranged alternately. The visible light-transparent and radiative-cooling multilayer film adopts a new film layer arrangement, so that the multilayer film has an extremely high visible light transmittance while achieving radiative cooling. Among others, the multilayer film is composed of two materials having high visible light-transmittance. Since there is a difference between dielectric constants of the two materials, a resonant cavity or resonant cavities may be formed among material layers. The resonant cavity may enhance the electric field therein, thereby increasing the radiance of the structure greatly. The present disclosure has the advantages of simple structure, easy to process, good cooling effect, high visible light transmittance and low cost.

Abstract: An ultrasound imaging device and system, and an image enhancement method for ultrasound radiography and imaging. Image enhancement coefficients of location points in a examined biological tissue are computed first according to radiography channel data, and then, weighted processing is performed on the image enhancement coefficients and beam forming data.

Abstract: A system for resource recycling of sulfur dioxide includes a charcoal reduction furnace, a high temperature dust remover, a cooling separator A, a liquid sulfur tank, a cooling separator, a tail gas absorption tower, a gas stripping tower, a hypo reactor, a centrifuge, a mother liquor tank and a thickener. And a method for resource recycling of sulfur dioxide includes the following steps: (1) preparing elemental sulfur, (2) removing dust from a process gas containing gaseous sulfur, (3) separating elemental sulfur, (4) reabsorbing residual SO2 gas, (5) purifying sulfur powder, (6) preparing a slurry of cured hypo, (7) performing liquid-solid separation, and (8) preparing an absorption slurry. According to the method, SO2 gas is reduced into liquid sulfur and sulfur powder, and sodium thiosulfate is coproduced.

Abstract: A method for etching a curved substrate is provided, including: forming a conductive thin film layer with an etched pattern on the curved substrate; supplying power to the conductive thin film layer such that the conductive thin film layer has an equal potential at each position of the conductive thin film layer; etching each position of the curved substrate to an etching depth corresponding to the potential at each position of the conductive thin film layer based on the etched pattern of the conductive thin film layer, so as to obtain the curved substrate having a consistent etching depth at each position of the curved substrate. With the etching method, it is possible to etch an arbitrary curved surface to obtain a microstructure with a uniform processing depth.

Abstract: Provided is an intelligent correction device control system for a super-resolution lithography precision mask, including: a sixteen-way pneumatic fine-tuning mask deformation control subsystem configured to deform a mask, detect a force value of a mask deformation, compare the force value of the mask deformation with an output force set value, and generate a first control feedback quantity to adjust a force deforming the mask, so as to control a deformation quantity of the mask; and an alignment subsystem configured to acquire images of the mask and a substrate, and adjust a position between the mask and the substrate according to the images, so as to align the mask with the substrate.

Abstract: The present invention relates to a macrocyclic JAK inhibitor and the uses thereof. Specifically, the present invention relates to a compound represented by formula I, or a stereoisomer or an optical isomer, a pharmaceutically acceptable salt, or a prodmg or a solvate thereof; and also relates to a pharmaceutical composition of the compound, and the medical uses thereof as a JAK inhibitor and in the preparation of a drug for preventing and/or treating diseases related to JAK, especially JAK3.

Abstract: Liquid polybutadiene, and a preparation method therefor and an application thereof are provided. The liquid polybutadiene has a number-average molecular weight of 2,500-5,500 and a molecular weight distribution index of 1-1.2. Based on the total amount of the liquid polybutadiene, the content of a 1,2-structural unit in the liquid polybutadiene is 85-95 wt %, the content of a 1,4-structural unit in the liquid polybutadiene is 5-15 wt %, and the molar ratio of a cis-1,4-structural unit to a trans-1,4-structural unit in the liquid polybutadiene is 1-2:1; and the dynamic viscosity of the liquid polybutadiene at 45° C. is 100-500 P. The liquid polybutadiene has good flowability, good film formability, and good coating performance, and a formed coating has an improved adhesion force to a substrate.

Abstract: Provided is a method of fabricating a micro-nano structure, including: forming a reflective layer and a fluid polymer layer sequentially on a surface of a substrate; pressurizing the substrate and a mask having a micro-nano pattern to attach to each other, squeezing the fluid polymer layer into a light-transmission area of the mask, and curing the fluid polymer layer; and exposing, wherein a fluid polymer in the light-transmission area is configured to sense light under a combined effect of a transmitted light and a light reflected by the reflective layer, such that a micro-nano structure is obtained. The method solves the problem of limited diffraction, improves the processing resolution by reducing the transmission loss of evanescent waves through reflective light field enhancement, and reduces the difficulty and cost of mask processing and pattern defects by using shallow pressurizing in combination with exposure.

Abstract: A method for etching a curved substrate is provided, including: forming a conductive thin film layer with an etched pattern on the curved substrate; supplying power to the conductive thin film layer such that the conductive thin film layer has an equal potential at each position of the conductive thin film layer; etching each position of the curved substrate to an etching depth corresponding to the potential at each position of the conductive thin film layer based on the etched pattern of the conductive thin film layer, so as to obtain the curved substrate having a consistent etching depth at each position of the curved substrate. With the etching method, it is possible to etch an arbitrary curved surface to obtain a microstructure with a uniform processing depth.

Abstract: The present invention relates to a macrocyclic JAK inhibitor and the use thereof. The present invention specifically relates to a compound as shown in formula I, or a stereoisomer or optical isomer thereof, a pharmaceutically acceptable salt thereof, and a prodrug or solvate thereof, and also relates to a pharmaceutical composition of the compound and the medical use thereof as a JAK inhibitor, and in the preparation of medicaments for preventing and/or treating diseases related to JAK, especially JAK1.

Abstract: Representation learning for text and speech has improved many language-related tasks. However, existing methods only learn from one input modality, while a unified representation for both speech and text is needed for tasks such as end-to-end speech translation. Consequently, these methods cannot exploit various large-scale text and speech data and their performance is limited by the scarcity of parallel speech translation data. To address these problems, embodiments of a fused acoustic and text masked language model (FAT-MLM) are disclosed. FAT-MLM embodiments jointly learn a unified representation for both acoustic and text input from various types of corpora including parallel data for speech recognition and machine translation, and pure speech and text data. Within this cross-modal representation learning framework, an end-to-end model is further presented for fused acoustic and text speech translation.

Abstract: Provided is a method of fabricating a micro-nano structure, including: forming a reflective layer and a fluid polymer layer sequentially on a surface of a substrate; pressurizing the substrate and a mask having a micro-nano pattern to attach to each other, squeezing the fluid polymer layer into a light-transmission area of the mask, and curing the fluid polymer layer; and exposing, wherein a fluid polymer in the light-transmission area is configured to sense light under a combined effect of a transmitted light and a light reflected by the reflective layer, such that a micro-nano structure is obtained. The method solves the problem of limited diffraction, improves the processing resolution by reducing the transmission loss of evanescent waves through reflective light field enhancement, and reduces the difficulty and cost of mask processing and pattern defects by using shallow pressurizing in combination with exposure.

Abstract: Provided is a multifunctional lithography device, including: a vacuum substrate-carrying stage configured to place a substrate and adsorb the substrate on the vacuum substrate-carrying stage by controlling an airflow, so as to control a gap between the substrate and the mask plate; a mask frame arranged above the vacuum substrate-carrying stage and configured to fix the mask plate; a substrate-carrying stage motion system arranged below the vacuum substrate-carrying stage and configured to adjust a position of the vacuum substrate-carrying stage, so that a distance between the substrate and the mask plate satisfies a preset condition; an ultraviolet light source system arranged above the mask plate and configured to generate an ultraviolet light for lithography; and a three-axis alignment optical path system configured to align the ultraviolet light with the mask plate.

Abstract: Provided is an intelligent correction device control system for a super-resolution lithography precision mask, including: a sixteen-way pneumatic fine-tuning mask deformation control subsystem configured to deform a mask, detect a force value of a mask deformation, compare the force value of the mask deformation with an output force set value, and generate a first control feedback quantity to adjust a force deforming the mask, so as to control a deformation quantity of the mask; and an alignment subsystem configured to acquire images of the mask and a substrate, and adjust a position between the mask and the substrate according to the images, so as to align the mask with the substrate.

Abstract: A data transmission method includes receiving, by a gateway of an integration platform as a service (iPaaS) system, a data transmission request transmitted by the iPaaS system, the iPaaS system being deployed on a first virtual private cloud (VPC) in a cloud network. The method further includes determining an address identifier of the service to be accessed by the iPaaS system, and a first transmission connection between the gateway and a data transmission circuitry associated with the service. The data transmission circuitry is connected to an Intranet, and the service is deployed in the Intranet or in a second VPC. The method further includes transmitting the data transmission request and the address identifier of the service from the gateway to the data transmission circuitry through the first transmission connection, where the data transmission circuitry transmits the data transmission request of the iPaaS system to the service.

Abstract: The present invention relates to a method for tracking, monitoring and evaluating ecological impacts of a channel project based on long-term time series satellite remote sensing data, belonging to the field of ecological environment protection. Created in view of limitations and deficiencies of existing monitoring and evaluation methods, the method includes: a process for long-term time series satellite remote sensing analysis of an ecological impact of a channel project, an analysis method for respectively evaluating erosion and deposition, shoreline and water area morphological changes at different research scales based on water body information extraction, and an analysis method for respectively tracking and monitoring engineering construction details, comparing engineering impact scope consistency and evaluating engineering implementation effects based on channel project identification.

Abstract: The present invention provides a 2-polysubstituted aromatic ring-pyrimidine derivative and an optical isomer thereof, or a pharmaceutically acceptable salt or solvate thereof, the compound, and an optical isomer thereof or a pharmaceutically thereof acceptable salts or solvates can be used in the preparation of anti-tumor drugs. The invention designs and synthesizes a series of novel small molecule Chk1 inhibitors by using N-substituted pyridin-2-aminopyrimidine obtained by structure-based virtual screening as a lead compound, and carries out Chk1 kinase inhibitory activity test. The experiment confirmed that said compounds possess potent anticancer activity, Chk1 kinase inhibitory activity, and are promising Chk1 inhibitors, and can be used as new cancer therapeutic drugs, which can be applied to treat solid tumors or hematologic tumors related to proliferative disease of human or animal.

Abstract: The present disclosure provides an open-air circulating pool for simulating ecological damage, and belongs to the technical field of simulation tests of ecological environment impact. The open-air circulating pool is provided with a set of devices for simulating natural ecological environments of different water quality and sediments, as well as changes in water bodies caused by a sea occupation project, discharge of a typical pollution source and a sudden leakage accident, so as to observe changing trends of an aquatic organism and an environmental element, and qualitatively and quantitatively determine a law of causality of damage. The set of devices includes an open-air wave-flow circulating pool, an additive injection apparatus and an ecological indicator sampling and detection apparatus.

Abstract: The present disclosure provides a sub-wavelength structural material having compatibility of low detectability for infrared, laser, and microwave, which includes, from top to bottom, a metal type frequency selective surface layer I, a dielectric layer I, a metal type frequency selective surface layer II, a dielectric layer II, a resistive film, a dielectric layer III. Each of the metal type frequency selective surface layers is a sub-wavelength patch type array, and metal used by the metal type frequency selective surface layers has a characteristic of low infrared emissivity. The present disclosure modulates a phase by using a phase difference generated by patches with different sizes on the metal type frequency selective surface layer I, so as to control backscattering of incident electromagnetic waves to achieve compatibility of low detectability for laser and infrared, while the bottom three layers achieve absorption of microwave.