Patents by Inventor Ming Chen Liu

Ming Chen Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury
    Patent number: 8557526
    Abstract: Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (CSF). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: October 15, 2013
    Assignees: University of Florida Research Foundation, Inc., Banyan Biomarkers, Inc.
    Inventors: Andrew K. Ottens, Firas H. Kobaissy, Ka-Wang (Kevin) Wang, Ronald L. Hayes, Zhiqun Zhang, Ming Chen Liu, Monika Oli
  • Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining
    Patent number: 8298835
    Abstract: The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: October 30, 2012
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Ka-Wang (Kevin) Wang, Ming Chen Liu
  • SYNAPTOTAGMIN AND COLLAPSIN RESPONSE MEDIATOR PROTEIN AS BIOMARKERS FOR TRAUMATIC BRAIN INJURY
    Publication number: 20120196307
    Abstract: Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological samples after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (biological samples). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
    Type: Application
    Filed: December 27, 2011
    Publication date: August 2, 2012
    Applicants: Banyan Biomarkers, Inc., University of Florida Research Foundation, Inc.
    Inventors: ANDREW K. OTTENS, Firas H. Kobaissy, Ka-Wang (Kevin) Wang, Ronald L. Hayes, Zhiqun Zhang, Ming Chen Liu, Monika Oli
  • Synaptotagmin and Collapsin Response Mediator Protein as Biomarkers for Traumatic Brain Injury
    Publication number: 20100047817
    Abstract: Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (CSF). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
    Type: Application
    Filed: August 5, 2009
    Publication date: February 25, 2010
    Applicants: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., BANYAN BIOMARKERS, INC.
    Inventors: Andrew K. Ottens, Firas H. Kobaissy, Ka-Wang (Kevin) Wang, Ronald L. Hayes, Zhiqun Zhang, Ming Chen Liu, Monika Oli
  • Proteolytic Markers as Diagnostic Biomarkers for Cancer, Organ Injury and Muscle Rehabilitation/Exercise Overtraining
    Publication number: 20090317805
    Abstract: The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
    Type: Application
    Filed: June 11, 2008
    Publication date: December 24, 2009
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Ka-Wang (Kevin) Wang, Ming Chen Liu
  • Neural Proteins as Biomarkers for Nervous System Injury and Other Neural Disorders
    Publication number: 20090087868
    Abstract: The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
    Type: Application
    Filed: June 11, 2008
    Publication date: April 2, 2009
    Inventors: Kevin Ka-Wang Wang, Ronald Hayes, Ming Chen Liu, Monika Oli
  • Proteolytic biomarkers for traumatic injury to the nervous system
    Patent number: 7456027
    Abstract: The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: November 25, 2008
    Assignees: University of Florida Research Foundation, Inc., Banyan Biomarkers, Inc.
    Inventors: Kevin Ka-Wang Wang, Ronald Hayes, Ming Chen Liu, Monika Oli
  • Neural proteins as biomarkers for traumatic brain injury
    Patent number: 7396654
    Abstract: The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: July 8, 2008
    Assignees: University of Florida Research Foundation, Inc., Banyan Biomarkers, Inc.
    Inventors: Ronald Hayes, Kevin Ka-Wang Wang, Ming Chen Liu, Monika Oli