Abstract: The present disclosure pertains to non-porous composite particles that are non-porous, polymer-based particles. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-inorganic material is in contact with the modified surface of the core, and a bonding material is in contact with the non-porous hybrid organic-inorganic material. The present disclosure pertains to chromatographic separation devices that comprise such non-porous composite particles.

Abstract: The present disclosure pertains to core-shell particles that are superficially porous, polymer-based, and include organic-inorganic materials. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-inorganic material is in contact with the modified surface of the core, and a porous hybrid organic-inorganic material is in contact with the non-porous hybrid organic-inorganic material. The present disclosure pertains to chromatographic separation devices that comprise such core-shell particles.

Abstract: The present disclosure pertains to non-porous composite particles that are non-porous, polymer-based, organic-inorganic materials. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-inorganic material is disposed on the modified surface of the core. The present disclosure pertains to chromatographic separation devices that comprise such non-porous composite particles.

Abstract: The present disclosure pertains to composite particles with polymer-based cores, which eliminate the high pH failure mechanism of silica-based core-shell silica particles. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-inorganic material is in contact with the modified surface of the core, and a porous inorganic material is in contact with the non-porous hybrid organic-inorganic material. The present disclosure pertains to chromatographic separation devices that comprise such composite particles.

Abstract: The present disclosure is directed to surface modified materials such as stationary phase materials for performing size exclusion chromatography. Aspects of the present disclosure feature materials surface modified with a moiety including a polyethylene glycol (PEG) functionality and a moiety comprising a diol functionality. Such surface modified materials exhibit a reduced propensity for ionic and hydrophobic secondary interactions.

Abstract: Provided herein chiral derivatization reagents for use in separating and detecting of amine containing enantiomers. The said chiral derivatization reagents provide a combination of improved detectable properties to facilitate various downstream analyses. In particular, the chiral derivatization reagents include at least one chiral carbon atom; at least one strongly basic moiety; at least one chromophore moiety or at least one fluorophore moiety; and at least one reactive group. The present disclosure further provides methods for analyzing amine-containing enantiomeric isomers using a chromatographic separation device and a mass spectroscopy.

Abstract: In various embodiments, the present disclosure pertains to core-shell particles that comprise a porous hybrid organic-inorganic shell disposed on a surface-modified non-porous polymer particle core. In some embodiments, the present disclosure pertains to chromatographic separation devices that comprise such core-shell particles. In some embodiments, the present disclosure pertains to chromatographic methods that comprise: (a) loading a sample onto a chromatographic column comprising such core-shell particles and (b) flowing a mobile phase through the column.

Abstract: In various embodiments, the present disclosure pertains to organic polymer core-shell particles that comprise a non-porous organic polymer core (i.e., having a pore volume of less than 0.1 cc/g) and a porous organic polymer shell (i.e., having a pore volume of greater than 0.1 cc/g), in which the porous organic polymer shell has a pore size ranging from 100 ? to 3000 ?. In some embodiments, the present disclosure pertains to chromatographic separation devices that comprise such organic polymer core-shell particles. In some embodiments, the present disclosure pertains to chromatographic methods that comprise: (a) loading a sample onto a chromatographic column comprising such organic polymer core-shell particles and (b) flowing a mobile phase through the column.

Abstract: The present disclosure relates to a system for separating a sample including a device and a positive pressure source. The device can include a housing with a proximal end having an interface and a proximal end opening, a distal end opening opposite the proximal end opening, and an interior wall defining an interior of the housing; a bottom frit connected to the interior wall, extending across the interior of the housing, and located proximately to the distal end to minimize sample loss; and a resin disposed within the interior of the housing between the bottom frit and the proximal end. The positive pressure source can connect to the interface of the proximal end to apply positive pressure to the sample. A controller can control the applied positive pressure to the sample via the positive pressure source according to a relationship between the bottom frit, the resin, and the positive pressure.

Abstract: The present invention provides porous materials for use in solid phase extractions and chromatography. In particular, the materials exhibit superior properties in the SPE analysis of biological materials. In certain aspects, the porous materials comprise a copolymer of a least one hydrophobic monomer and at least one hydrophilic monomer, wherein more than 10% of the BJH surface area of the porous material is contributed by pores that have a diameter greater than or equal to 200 ?, wherein said material has a median pore diameter of about 100 ? to about 1000 ?, or both. In some embodiments, the at least one hydrophilic monomer has a log P value of less than 0.5. In some embodiments, the at least one hydrophilic monomer is selected from 4-acryloymorphine, N-(3-methoxypropyl)acrylamide, N,N?-methylenebis(acrylamide), acrylonitrile, ethylene glycol dimethacrylate, methyl acrylate, 4-acetoxystyrene, 4-vinyl pyridine, or a boronic-acid-containing monomer, among others.

Abstract: The current invention provides a novel method to synthesize a mono-disperse non-porous polymer particles with a unique gradient composition from the core to the shell. In particular, The present invention offers the flexibility to design the chemical and physical properties of different sections of the particle. This flexibility allows for significant latitude in the design of particles for analyzing a large variety of samples in different fields—through using these particles in different chromatography techniques including, but not limited to, ion exchange HPLC (e.g., bio-separation at different modes), reversed-phase HPLC, narrow bore and capillary HPLC, hydrophilic/hydrophobic interaction liquid chromatography, capillary electrochromatography separation, and two dimensional liquid chromatography.

Abstract: Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated. Uniformity in the direction flow is improved by controlling polymerization with radiation rather than with conducted heat.

Abstract: Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated. Uniformity in the direction flow is improved by controlling polymerization with radiation rather than with conducted heat.

Abstract: A flexible framing format and implementation scheme for transmitting uncompressed video data selected from a group of various video formats, audio data and control data over a single serial communication channel at a fixed clock rate, thereby eliminating the need for transmitting a pixel clock signal. The data is transmitted over the single communication channel in packets and recreated at the destination side. Blank pixels of the video data are completely suppressed so that only active pixels are transmitted over the single communication channel, thereby reducing communication bandwidth requirement of the channel.

Abstract: Implementation schemes for transmitting High-Bandwidth Digital Content (HDCP) control-related data in HDCP systems over a single communication channel.

Abstract: Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated. Uniformity in the direction flow is improved by controlling polymerization with radiation rather than with conducted heat.

Abstract: A serial transmission protocol and architecture are provided that can be used to transmit uncompressed multimedia (e.g., video/audio/control data) over a high speed serial forward communication channel. A backward channel is also provided, for communicating control data. The protocol is implemented with a flexible packet format that supports all different modes of video data, and also supports 24 bit and 30 bit video data (or higher). An example application where the architecture and protocol can be used is a home entertainment multimedia system. A mechanism to implement EDID pass-through and protocols such as HDCP is also provided.

Abstract: A serial transmission protocol and architecture are provided that can be used to transmit uncompressed multimedia (e.g., video/audio/control data) over a high speed serial forward communication channel. A backward channel is also provided, for communicating control data. The protocol is implemented with a flexible packet format that supports all different modes of video data, and also supports 24 bit and 30 bit video data (or higher). An example application where the architecture and protocol can be used is a home entertainment multimedia system. A mechanism to implement EDID pass-through and protocols such as HDCP is also provided.

Abstract: A serial transmission protocol and architecture are provided that can be used to forward remote control data between sink (e.g., DTV) and source (e.g., DVD player) devices, in addition to other data such as video and/or audio or other payload. The target device need not be in the line of sight of the remote control beam. Daisy-chained devices will pass the remote control signal to the appropriate target device, so that the user can point any remote control at the DTV or other conveniently located device in the system, and still control the actual target device. The communication channel that carries payload, processing control, and remote control data can be implemented with wired or wireless of technology (or a combination thereof). In one particular embodiment, the communication channel is implemented with a single fiber. A number of presentation and entertainment system applications that employ remote control technology (e.g.

Abstract: Infrared control signals are repeated and communicated in a system including a source device and a sink device that are communicatively coupled by a serial communication link that includes a forward channel and a backward channel. Modulated infrared remote control data is detected by an infrared detector without de-modulation, and sampled in modulated form. Sampled data corresponding to the modulated remote control signal is transmitted from the sink device to the source device over the serial communication link, which in one example is a single optical fiber. The source device receives the sampled data and regenerates the infrared control data, which is then used to control the operation of the source device.