Patents by Inventor Ming Dong Zhou

Ming Dong Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Retinoid suppression of ventricular muscle cell hypertrophy
    Patent number: 6221618
    Abstract: The invention features methods of identifying a compound which suppresses ventricular muscle cell hypertrophy. In one embodiment, ventricular muscle cells are contacted with a test compound, which acts through an RAR or RXR receptor, in the presence of an inducer of hypertrophy. Development of ventricular muscle cell hypertrophy is then measured to identify compounds having the desired activity.
    Type: Grant
    Filed: January 13, 2000
    Date of Patent: April 24, 2001
    Inventors: Kenneth R. Chien, Ming Dong Zhou
  • Retinoid suppression of ventricular muscle cell hypertrophy
    Patent number: 6060311
    Abstract: The invention provides a method of suppressing ventricular muscle cell hypertrophy induced by an .alpha..sub.1 -adrenergic agonist or endothelin, by providing an effective amount of a retinoic acid compound.
    Type: Grant
    Filed: March 10, 1998
    Date of Patent: May 9, 2000
    Assignee: The Regents of the University of California
    Inventors: Kenneth R. Chien, Ming Dong Zhou
  • Retinoid suppression of ventricular muscle cell hypertrophy
    Patent number: 5968981
    Abstract: A method of suppressing ventricular muscle cell hypertrophy induced by an .alpha..sub.1 -adrenergic agonist or endothelin, by providing an effective amount of a retinoic acid compound. Also provided are methods for identifying compounds which suppress ventricular muscle cell hypertrophy, compounds which inhibit the retinoic acid suppression of ventricular muscle cell hypertrophy, and therapeutic methods.
    Type: Grant
    Filed: March 10, 1998
    Date of Patent: October 19, 1999
    Assignee: The Regents of the University of California
    Inventors: Kenneth R. Chien, Ming Dong Zhou
  • Retinoid suppression of ventricular muscle cell hypertrophy
    Patent number: 5767155
    Abstract: A method of suppressing ventricular muscle cell hypertrophy induced by an .alpha..sub.1 -adrenergic agonist or endothelin, by providing an effective amount of a retinoic acid compound. Also provided are methods for identifying compounds which suppress ventricular muscle cell hypertrophy, compounds which inhibit the retinoic acid suppression of ventricular muscle cell hypertrophy, and therapeutic methods.
    Type: Grant
    Filed: July 22, 1996
    Date of Patent: June 16, 1998
    Assignee: The Regents of the University of California
    Inventors: Kenneth R. Chien, Ming Dong Zhou