Abstract: Scene aware video content encoding techniques can determine if video content is a given content type and is one of one or more given titles that include one or more given scenes. The one or more given scenes of the video content of the given type and given one of the titles can be encoded using corresponding scenes specific encoding parameter values, and the non-given scenes can be encoded using one or more general encoding parameter values. The one or more given titles can be selected based on a rate of streaming of various video content titles of the given type.

Abstract: Provided are, inter alia, compounds having a structure of Formula (X), (XI), (XII), or (XIII), or a subordinate structure thereof, composition including the same and methods of use.

Abstract: Provided are, inter alia, compounds having a structure of Formulae (X) to (XVII), or a subordinate structure thereof, composition including the same and methods of use.

Abstract: Provided are, inter alia, compounds having a structure of Formula (X), or a pharmaceutically acceptable salt thereof composition including the same and methods of use. Ring A, L1, L2, W, R2A, R2B, and R10 are as described herein.

Abstract: Methods of preventing disease or treating a subject likely to develop or having a neurodegenerative, degenerative or metabolic disease include administration of nicotinamide dinucleotide (NAD) modulating agents. Compositions include one or more agents which increase or decrease NAD in vivo or in vitro.

Abstract: A fully electrically controlled intelligent subsurface safety valve is provided, including an upper joint, a lower joint, a magnetic switch, an upper electromagnetic suction module, a central flow pipe, a magnetic piston ring, a lower electromagnetic suction module, a rebound flap valve mechanism, a displacement sensor, a temperature and pressure sensor, a flow sensor, and a power communication composite cable connector. With the magnetic assisted reset of the two electromagnetic suction modules, the safety valve closes more quickly in emergency situations, improving the reliability of the safety valve. By using a magnetic excitation switch, the safety valve can be quickly opened and closed, and the open or close state can be maintained independently, saving energy consumption in the control system. The present disclosure can better meet the needs of onshore and offshore oil and gas production operations and gas storage operations.

Abstract: Compounds described herein may be used for the treatment of neurodegenerative diseases linked to protein misfolding, including prion diseases, Alzheimer's disease, Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), and also other neurodegenerative, degenerative, metabolic and ischemic conditions. Indeed, NAD metabolism impairment is also a critical feature in brain ischemia/reperfusion injury, Wallerian degeneration, kidney failure, multiple sclerosis, aging, and metabolic disorders such as diabetes mellitus. Therapies that elevate or stabilize NAD levels may thus have broad potential for treating many severely debilitating neurological and metabolic conditions. Evidence is provided herein with compounds from 8 lead series for NAD restoring properties and for therapeutic efficacy in cellular and/or animal models of prion disease, PD and ALS.

Abstract: The invention provides methods for generating and screening agents that are useful for treating, diagnosing and monitoring Parkinson's Disease and other synucleinopathies.