Abstract: An antimicrobial article includes a supporting layer and an antimicrobial layer. The antimicrobial layer has a first major surface at least partially formed by a plurality of particles and a second major surface coupled to the supporting layer. Each particle of the plurality of particles is formed by a bead of nonconductive material. A first set of the particles include beads coated by a first conductive material.

Abstract: Described herein is composition comprising salicylic acid for use as a treatment article for certain conditions and method of making such an article. The composition comprising: salicylic acid; a silicone containing film-forming polymer; a silicate tackifying resin; and an additive, wherein the additive comprises (i) a nonionic surfactant having an HLB of 5-9, (ii) a aminosilicone having an amine value greater than 60, (iii) a cationic silicone polyquaternium, or (iv) combinations thereof. Such compositions can be used for skin treatment applications.

Abstract: The present disclosure provides an article for detecting extravasation into a tissue. The article includes a body having a first major surface, an opposing second major surface, a first side, and an opposing second side. The article further includes a first electrode disposed on the first major surface of the body. The first electrode includes at least one skin-penetrating microfeature. The article further includes a second electrode disposed on the first major surface of the body. The second electrode includes at least one skin-penetrating microfeature. The first electrode is electrically connected to the second electrode.

Abstract: Viral filtration media, an article comprising the viral filtration media, and a method of filtering a virus-containing sample using the viral filtration media, wherein the viral filtration media comprises: a porous substrate comprising a surface having a polymer grafted thereto, wherein the grafted polymer comprises interpolymerized monomers comprising: a (meth)acrylic acid monomer: and, optionally, a poly (alkylene oxide) monomer.

Abstract: An article for assessing efficacy of a sterilization process is provided. The article includes a housing, a plurality of genetically-modified spore-forming test microorganisms disposed in the housing, a liquid medium disposed in an openable container that is disposed in or attached to the housing, and an enzyme substrate disposed in the housing or in the openable container. The genetically-modified test microorganism comprises a functional fusion gene that encodes a non-naturally occurring chimeric protein, the chimeric protein comprising a first segment and a second segment that is contiguous with the first segment. The first segment comprises at least a portion of a first polypeptide that is normally found in spores and the second segment comprises a second polypeptide having a detectable enzymatic activity. The enzyme substrate is capable of reacting with the detectable enzyme activity to form a detectable product. A method of using the test microorganisms is also provided.

Abstract: A composition and method of detecting an analyte in a sample using the composition, the composition including: a liquid that includes water; a plurality of first hollow glass bubbles in the liquid; a plurality of covalently attached first affinity groups that are covalently attached to at least some of the plurality of first hollow glass bubbles; and a plurality of first detector compound molecules not covalently bonded to the plurality of first hollow glass bubbles; wherein the first detector compound molecules include a first detectable group that is detected at a first wavelength; and wherein the first hollow glass bubbles have: a density of less than 0.60 gram/mole; a span of less than 1.0; and a plurality of covalently attached first affinity groups.

Abstract: An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site and a second surface opposite the first surface; wherein at least one of the interconnected polymeric stand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; a plurality of openings between adjacent interconnected polymeric strands; an adhesive layer in contact with the second surface of the interconnected polymeric strands; and a filler in contact with the adhesive layer, the adhesive layer in between the network of interconnected polymeric strands and the filler; wherein the article is a negative pressure wound therapy article.

Abstract: The invention provides a dynamic seal test device for cryogenic fluid medium. The dynamic seal test device includes stator unit, rotor unit, slipway, servo motor unit and sensors. The tested seal is installed inside the stator, and the thermal insulation stator and vacuum rotor together form a dynamic seal test structure. The seals and shaft sleeves can be flexibly replaced, which is beneficial to study the influence of different seal types, structure, and seal land configurations on the sealing performance. The servo motor provides power for the rotor and controls the rotation speed. The device greatly improves the thermal insulation capacity to avoid the gasification for the cryogenic fluid medium induced by the heat transfer from environment so that ensuring the stability of the test device.

Abstract: A polypeptide having a sequence at least 60% identical to SEQ ID NO: 1 (WFEWPYWEMNVPDVWN) is provided. The polypeptide includes no more than 100 total amino acid residues.

Abstract: The invention provides a dynamic seal test device for cryogenic fluid medium. The dynamic seal test device includes stator unit, rotor unit, slipway, servo motor unit and sensors. The tested seal is installed inside the stator, and the thermal insulation stator and vacuum rotor together form a dynamic seal test structure. The seals and shaft sleeves can be flexibly replaced, which is beneficial to study the influence of different seal types, structure, and seal land configurations on the sealing performance. The servo motor provides power for the rotor and controls the rotation speed. The device greatly improves the thermal insulation capacity to avoid the gasification for the cryogenic fluid medium induced by the heat transfer from environment so that ensuring the stability of the test device.

Abstract: A polypeptide having a sequence at least 70% identical to SEQ ID NO: 1 (YVSPGMKNVNWWSHWWHATD) is provided. The polypeptide includes no more than 100 total amino acid residues.

Abstract: An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site and a second surface opposite the first surface; wherein at least one of the interconnected polymeric stand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; a plurality of openings between adjacent interconnected polymeric strands; an adhesive layer in contact with the second surface of the interconnected polymeric strands; and a filler in contact with the adhesive layer, the adhesive layer in between the network of interconnected polymeric strands and the filler; wherein the article is a negative pressure wound therapy article.

Abstract: An article including: a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site; wherein none of the interconnected polymeric strand has a feature extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; and a plurality of openings between adjacent interconnected polymeric strands; wherein the article is a negative pressure wound therapy article

Abstract: A polypeptide having a sequence at least 70% identical to SEQ ID NO: 1 (YVSPGMKNVNWWSHWWHATD) is provided. The polypeptide includes no more than 100 total amino acid residues.

Abstract: An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site; wherein at least one of the interconnected polymeric strand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein only one of any two adjacent polymeric strands has a plurality of features extending from the first surface of the interconnected polymeric strands; and wherein at least one of the interconnected polymeric strands is non-linear; and a plurality of openings between adjacent interconnected polymeric strands.

Abstract: A polypeptide having a sequence at least 60% identical to SEQ ID NO: 1 (WFEWPYWEMNVPDVWN) is provided. The polypeptide includes no more than 100 total amino acid residues.

Abstract: Assay devices are provided including a receptacle having a sample entry port; a plunger disposed within the receptacle; at least one reagent; a membrane attached to a first surface of the plunger; a wick providing capillary force; and a detection zone. The membrane includes a target conjugate zone in which affinity components are disposed. Capture compounds are immobilized in a detection zone, which is located between the target conjugate zone and the wick. A method of detecting a target analyte is also provided, including providing the assay device; providing a sample suspected to contain a target analyte; adding the sample onto the device; allowing the sample to travel along the membrane until the sample reaches the detection zone; immobilizing the target analyte through reaction of the target analyte with the capture compounds; reacting the immobilized target analyte with a reagent to generate a detectable signal; and detecting the generated signal.

Abstract: An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site; wherein at least one of the interconnected polymeric strand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; and a plurality of openings between adjacent polymeric strands; wherein the article is a negative pressure wound therapy article.

Abstract: Assay devices are provided including a receptacle having a sample entry port; a plunger disposed within the receptacle; at least one reagent; a membrane attached to a first surface of the plunger; a wick providing capillary force; and a detection zone. The membrane includes a target conjugate zone in which affinity components are disposed. Capture compounds are immobilized in a detection zone, which is located between the target conjugate zone and the wick. A method of detecting a target analyte is also provided, including providing the assay device; providing a sample suspected to contain a target analyte; adding the sample onto the device; allowing the sample to travel along the membrane until the sample reaches the detection zone; immobilizing the target analyte through reaction of the target analyte with the capture compounds; reacting the immobilized target analyte with a reagent to generate a detectable signal; and detecting the generated signal.