Patents by Inventor Minghuang Zhang

Minghuang Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF REDUCING THE SEVERITY OF MUCOSITIS
    Publication number: 20100279978
    Abstract: The invention provides methods of reducing the severity of mucositis, involving administration of a toll-like receptor 4 antagonist.
    Type: Application
    Filed: May 7, 2010
    Publication date: November 4, 2010
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Tetsu Kawano, Seiichi Kobayashi, Minghuang Zhang, Hiroshi Shirota
  • Methods of reducing the severity of mucositis
    Patent number: 7727974
    Abstract: The invention provides methods of reducing the severity of mucositis, involving administration of a toll-like receptor 4 antagonist.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: June 1, 2010
    Assignee: Eisai R & D Management Co., Ltd.
    Inventors: Tetsu Kawano, Seiichi Kobayashi, Minghuang Zhang, Hiroshi Shirota
  • cDNA Encoding a Gene Bog (B5T Over-Expressed Gene) and its Protein Product
    Publication number: 20100129791
    Abstract: Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-?1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
    Type: Application
    Filed: December 14, 2007
    Publication date: May 27, 2010
    Applicant: The Government of the United State, as represented by the Secretary, Dept. of Health & Human Service
    Inventors: Snorri S. Thorgeirsson, Joseph T. Woitach, Minghuang Zhang
  • Treatment and Prevention of Heat Shock Protein-Associated Diseases and Conditions
    Publication number: 20080096841
    Abstract: The invention provides methods of treating and preventing heat shock protein-associated diseases and conditions.
    Type: Application
    Filed: December 17, 2007
    Publication date: April 24, 2008
    Applicant: Eisai R&D Management Co. Ltd.
    Inventors: Seiichi Kobayashi, Minghuang Zhang, Hiroshi Shirota
  • cDNA encoding a gene BOG (B5T over-expressed gene) and its protein product
    Patent number: 7342099
    Abstract: Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-?1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: March 11, 2008
    Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
    Inventors: Snorri S. Thorgeirsson, Joseph T. Woitach, Minghuang Zhang
  • Methods of reducing the severity of mucositis
    Publication number: 20070072824
    Abstract: The invention provides methods of reducing the severity of mucositis, involving administration of a toll-like receptor 4 antagonist.
    Type: Application
    Filed: May 15, 2006
    Publication date: March 29, 2007
    Applicant: Eisai Co., Ltd.
    Inventors: Tetsu Kawano, Seiichi Kobayashi, Minghuang Zhang, Hiroshi Shirota
  • Treatment and prevention of heat shock protein-associated diseases and conditions
    Publication number: 20040254128
    Abstract: The invention provides methods of treating and preventing heat shock protein-associated diseases and conditions.
    Type: Application
    Filed: July 26, 2004
    Publication date: December 16, 2004
    Inventors: Seiichi Kobayashi, Minghuang Zhang, Hiroshi Shirota
  • cDNA encoding a gene BOG (B5T over-expressed gene) and its protein product
    Publication number: 20040139485
    Abstract: Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-&bgr;1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
    Type: Application
    Filed: February 5, 2004
    Publication date: July 15, 2004
    Applicant: The Government of the U.S. A, as presented by the Secretary, Department of Health and Human Services
    Inventors: Snorri S. Thorgeirsson, Joseph T. Woitach, Minghuang Zhang
  • cDNA encoding a gene BOG (B5T Over-expressed Gene) and its protein product
    Patent number: 6727079
    Abstract: Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-&bgr;1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: April 27, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Snorri S. Thorgeirsson, Joseph T. Woitach, Minghuang Zhang
  • Immunotherapeutic anti-cancer pharmaceutical compositions
    Patent number: 6482833
    Abstract: There is disclosed a class of pharmaceutical compositions useful for the treatment of cancer, particularly solid tumors, and having a mechanism of action as spermine antagonists. The present pharmaceutical compositions are able to inhibit the inhibitory effect of spermine upon macrophage function, and thus prevent spermine-induced immunosuppression.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: November 19, 2002
    Assignee: North Shore - Long Island Jewish Research Institute
    Inventors: Kevin J. Tracey, Minghuang Zhang
  • Immunotherapeutic anti-cancer pharmaceutical compositions
    Publication number: 20020122821
    Abstract: There is disclosed a class of pharmaceutical compositions useful for the treatment of cancer, particularly solid tumors, and having a mechanism of action as spermine antagonists. The present pharmaceutical compositions are able to inhibit the inhibitory effect of spermine upon macrophage function, and thus prevent spermine-induced immunosuppression.
    Type: Application
    Filed: January 18, 2000
    Publication date: September 5, 2002
    Inventors: Kevin J. Tracey, Minghuang Zhang
  • Immunotherapeutic anti-cancer pharmaceutical compositions
    Patent number: 6248356
    Abstract: There is disclosed a class of pharmaceutical compositions useful for the treatment of cancer, particularly solid tumors, and having a mechanism of action as spermine antagonists. The present pharmaceutical compositions are able to inhibit the inhibitory effect of spermine upon macrophage function, and thus prevent spermine-induced immunosuppression.
    Type: Grant
    Filed: June 13, 1997
    Date of Patent: June 19, 2001
    Assignee: The Picower Institut for Medical Research
    Inventors: Kevin J. Tracey, Minghuang Zhang