Patents by Inventor Mingjia YU

Mingjia YU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Neuronal nicotinic acetylcholine receptor-targeting polypeptide and use thereof
    Patent number: 11459356
    Abstract: A neuronal nicotinic acetylcholine receptor-targeting polypeptide and the use thereof are disclosed. The polypeptide has an amino acid sequence of SEQ ID NO:1, and includes four cysteine residues, Cys2, Cys3, Cys7, and Cys13, that can form two disulfide bonds. Molecular docking simulation illustrated its capacity to target a and a subunits of nAChR and the stable structure of resultant nAChR_BP-nAChR complex. In addition, effect of the polypeptide on calcium response of nAChR-overexpressing CN21 cells revealed that the polypeptide was capable of significantly inhibiting nAChRs. Accordingly, the nAChR-targeting polypeptide nAChR_BP is a promising nAChR-targeting drug.
    Type: Grant
    Filed: May 25, 2021
    Date of Patent: October 4, 2022
    Inventor: Mingjia Yu
  • NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR-TARGETING POLYPEPTIDE AND USE THEREOF
    Publication number: 20220242909
    Abstract: A neuronal nicotinic acetylcholine receptor-targeting polypeptide and the use thereof are disclosed. The polypeptide has an amino acid sequence of SEQ ID NO:1, and includes four cysteine residues, Cys2, Cys3, Cys7, and Cys13, that can form two disulfide bonds. Molecular docking simulation illustrated its capacity to target a and a subunits of nAChR and the stable structure of resultant nAChR_BP-nAChR complex. In addition, effect of the polypeptide on calcium response of nAChR-overexpressing CN21 cells revealed that the polypeptide was capable of significantly inhibiting nAChRs. Accordingly, the nAChR-targeting polypeptide nAChR_BP is a promising nAChR-targeting drug.
    Type: Application
    Filed: May 25, 2021
    Publication date: August 4, 2022
    Inventor: Mingjia YU