Abstract: The technology described herein is directed to methods, kits, compositions, and systems for detecting a target RNA, such as a small amount of viral RNA. In one aspect, described herein are methods of detecting the target RNA, using primers comprising at least one barcode region. In other aspects, described herein are kits, compositions, and systems suitable to practice the methods described herein to detect the target RNA.

Abstract: The technology described herein is directed to methods for obtaining partial sequence information from a target protein. Also described herein are systems, devices, and kits for obtaining partial sequence information from a target protein.

Abstract: The present disclosure provides, inter alia, methods and compositions (e.g., conjugates) for imaging, at high spatial resolution, targets of interest.

Abstract: Methods and systems for improved sample detection in mass spectroscopy are generally described. These are particularly useful, for example, for identifying a protein, a part of a protein, or a peptide when present in a low amount. In some embodiments, these can be useful to allow high-throughput proteomics studies for many samples, e.g., in series or in tandem. For example, certain embodiments are directed to novel approaches for identification of samples at the MS 1 level. In some cases, these improvements can be realized due to improvements in mass spectrometry instrumentation to better than the 1 ppm level for m/z measurements. Examples of improvements include, but are not limited to, improving internal mass standards, super-resolution peak fitting, isotopic labelling, Edman degradation and/or chromatography for proteins or peptides, and/or machine learning to predict peptide behavior, e.g., when exposed to such improvements.

Abstract: The present disclosure provides, in some embodiments, methods and compositions for single-molecule detection.

Abstract: The present disclosure provides, in some embodiments, methods and compositions for single-molecule detection.

Abstract: The present disclosure provides, inter alia, methods and compositions (e.g., conjugates) for imaging, at high spatial resolution, targets of interest.

Abstract: The present disclosure provides, in some embodiments, methods and compositions for single-molecule detection.

Abstract: This disclosure provides methods for generating super-resolution patterns of molecules on substrates.

Abstract: The invention provides SST motifs of controlled size and shape, comprised of a plurality of oligonucleotides, and methods for their synthesis. The motifs are formed, at least in part, by the self-assembly of single stranded oligonucleotides into curved, corrugated or twisted structures. The location of each oligonucleotide in the resultant motif is known. Accordingly, the motifs may be modified with specificity.

Abstract: This disclosure provides methods for generating super-resolution patterns of molecules on substrates.

Abstract: The present disclosure provides, inter alia, methods and compositions (e.g., conjugates) for imaging, at high spatial resolution, targets of interest.

Abstract: The invention provides SST motifs of controlled size and shape, comprised of a plurality of oligonucleotides, and methods for their synthesis. The motifs are formed, at least in part, by the self-assembly of single stranded oligonucleotides into curved, corrugated or twisted structures. The location of each oligonucleotide in the resultant motif is known. Accordingly, the motifs may be modified with specificity.