Abstract: An electrochemical device includes a transition metal oxide cathode, such as LiNi0.8Co0.1Mn0.1O2, and an electrolyte. The electrolyte includes N, N-dimethyltrifluoromethane-sulfonamide (DMTMSA) and lithium bis(fluorosulfonyl)imide (LiFSI). The DMTMSA and LiFSI may be either the primary component of the electrolyte or an additive in the electrolyte. The electrochemical device may also include a graphite anode or a lithium metal anode. With a lithium metal anode, the electrochemical device has an initial specific capacity of at least 231 mAh g?1. Over at least 100 cycles (upper cut-off voltage of 4.7±0.05 V vs. Li/Li+), the electrochemical device maintains an average specific capacity of at least 88% of the initial specific capacity and an average Coulombic efficiency of at least about 99.65%.

Abstract: A noncontact, multi-wavelength time-resolved laser speckle contrast imaging (MTR-LSCI) technique provides for continuous, fast and high-resolution 2D mapping of tissue blood flow (BF) and tissue blood oxygen saturation (StO2) at different depths of target tissue. MTR-LSCI illuminates the tissue with picosecond-pulsed, coherent, widefield light at least at two different wavelengths in the near-infrared range (600-1100 nm) and synchronizes a high-resolution, gated single-photon avalanche diode (SPAD) camera to capture BF and StO2 maps at different depths of target tissue, wherein the imaging depth depends on light propagation inside a tissue volume, captured by the time-gated camera. The reconstruction of BF and StO2 maps can be dramatically expedited by incorporating highly parallelized computation and convolution functions. The performance of MTR-LSCI was evaluated using head-simulating phantoms with known properties and in-vivo rodents with varied hemodynamic challenges to the brain.

Abstract: A nail gun having an energy storage mechanism for storing energy used for striking nails out of the nail gun, the energy storage mechanism comprises a guiding rod attached to a fixed plate assembly; a piston disposed on the guiding rod; a striking member mounted on the piston for striking the nails; at least one power spring disposed around an outer periphery of the guiding rod; a guide sleeve moveably disposed around the outer periphery of the guiding rod and between the power spring and the guiding rod; wherein a first end of the power spring abuts against the piston and is configured to be compressed to store energy.

Abstract: A nail gun having a driving and controlling mechanism. The driving and controlling mechanism comprises a driving assembly disposed inside a casing of the nail gun for striking nails in a striking direction; and a control assembly controlling the driving assembly. The driving assembly comprises a piston movably disposed inside the casing and attached to a striking member for striking the nails; at least one power spring in contact with the piston; a pushing component for pushing the piston towards the power spring; and a motor for rotating the pushing component. The control assembly comprises a main switch configured to produce a first electronic signal; and a safety switch configured to produce a second electronic signal. The main switch and the safety switch are in communication with the motor such that the motor is configured to operate when it receives both the first electronic signal and the second electronic signal.

Abstract: A class of sulfonimide salts for solid-state electrolytes can be synthesized based on successive SNAr reactions of fluorinated phenyl sulfonimides: Fluorinated Aryl Sulfonimide Tags (FAST). The chemical and electrochemical oxidative stability of these FAST salts as well as other properties like solubility, Lewis basicity, and conductivity can be tuned by introducing different numbers and types of nucleophilic functional groups to the FAST salt scaffold.

Abstract: The present invention discloses an ultra-high-polarity chiral liquid crystal material, a liquid crystal laser and a preparation method therefor. The ultra-high-polarity chiral liquid crystal material has, in a certain temperature range, a high dielectric constant of ?˜104 and a characteristic of extremely-strong second harmonic response 3 to 10 times as much as that of a quartz crystal, and a pitch of the ultra-high-polarity chiral liquid crystal material is adjusted within 0.1 to 1 micrometer according to a doped concentration of the chiral molecule.

Abstract: Provided are methods for treating paroxysmal nocturnal hemoglobinuria in a subject who previously exhibited an inadequate response to an anti-C5 antibody therapy, by administering to the subject a therapeutically effective amount of an inhibitor of the alternative pathway of complement (e.g., one which inhibits a target upstream to complement 5 (C5), such as Factor D or complement 3 (C3)). Also provided herein are methods for treating PNH in a human subject, comprising administering to the subject a complement factor D inhibitor alone or in combination with an anti-C5 antibody, or antigen binding fragment thereof. In some embodiments, the patient previously exhibited an inadequate response to an anti-C5 antibody therapy.

Abstract: This disclosure provides an ocular tissue depot of a selected complement factor D (CFD) inhibitor for the extended treatment of an ocular disorder mediated by complement factor D. In particular, the disclosure includes the creation of a drug depot within the choroid-retina pigmented epithelium (C-RPE) and/or the iris-ciliary body (I-CB) of the eye by means of the systemic (oral or parenteral) administration of the compound, where the compound accumulates in ocular tissue and is released over an extended period for the treatment of a posterior and/or anterior eye disorder.

Abstract: A class of sulfonimide salts for solid-state electrolytes can be synthesized based on successive SNAr reactions of fluorinated phenyl sulfonimides: Fluorinated Aryl Sulfonimide Tags (FAST). The chemical and electrochemical oxidative stability of these FAST salts as well as other properties like solubility, Lewis basicity, and conductivity can be tuned by introducing different numbers and types of nucleophilic functional groups to the FAST salt scaffold.

Abstract: A metal-oxygen battery can provide improved energy storage and transportation applications due to high gravimetric energies, and such a metal-oxygen battery can include a polyolefin including a plurality of functional groups such as sulfamide, sulfoxy, carbonyl, phosphoramide or heterocyclic groups.

Abstract: A polymer compound including a repeating unit represented by Formula: wherein R1, R2, R3, R4, a1, a2, and a11 in Formula 1 are as defined in the specification.

Abstract: Electrolytes and polymers for a lithium battery can include a fluorinated aryl sulfonimide salt or fluorinated aryl sulfonimide polymer.

Abstract: The dosages and methods described herein provide desirable pharmacokinetic (PK) and pharmacodynamics (PD) characteristics which inhibit alternative pathway complement activity, for example at least 85% or more inhibition of AP activity in vivo at dosages from about 120 mg to 200 mg BID that provides a plasma level Ctrough at least about 65 ng/ml, which provides sufficient AP inhibition to reduce the risk of complement breakthrough. In addition, the dosage form described herein provides a significantly low Cmax, providing additional safety margin and better dosing flexibility.

Abstract: Methods, compositions, reagents, and systems that allow for the preparation and utilization of sulfonamide salt polymer electrolytes are disclosed herein. Methods and reagents to prepare sulfonamide salt monomers are also disclosed herein. The sulfonamide salt polymer electrolytes can be used as components in energy storage devices, conductive materials, electrochemical cells, gels, adhesives, and drug delivery vehicles.

Abstract: Provided herein are methods for using determinative urinary biomarkers for identifying a human subject suffering from an alternative pathway (AP)-associated nephropathy. Also provided herein is a method for using determinative urinary biomarkers to determine whether a human subject suffering from a complement mediated nephropathy is likely to respond to an inhibitor of the alternative complement pathway (“AP”) in treating the complement mediated nephropathy. Further provided herein is a method for using urinary biomarkers to assess the therapeutic response of a human subject suffering from an AP-associated nephropathy receiving inhibitors of the complement alternative pathway (AP inhibitors).

Abstract: A class of sulfonimide salts for solid-state electrolytes can be synthesized based on successive SNAr reactions of fluorinated phenyl sulfonimides: Fluorinated Aryl Sulfonimide Tags (FAST). The chemical and electrochemical oxidative stability of these FAST salts as well as other properties like solubility, Lewis basicity, and conductivity can be tuned by introducing different numbers and types of nucleophilic functional groups to the FAST salt scaffold.

Abstract: A class of sulfonimide salts for solid-state electrolytes can be synthesized based on successive SNAr reactions of fluorinated phenyl sulfonimides: Fluorinated Aryl Sulfonimide Tags (FAST). The chemical and electrochemical oxidative stability of these FAST salts as well as other properties like solubility, Lewis basicity, and conductivity can be tuned by introducing different numbers and types of nucleophilic functional groups to the FAST salt scaffold.

Abstract: Electrolytes and polymers for a lithium battery can include a fluorinated aryl sulfonimide salt or fluorinated aryl sulfonimide polymer.

Abstract: Provided herein are methods for treating a subject with PNH comprising administering to a subject a therapeutically effective amount of complement component C5 (C5) inhibitor, complement component C3 (C3) inhibitor, or complement factor B (CFB) inhibitor in combination with a therapeutically effective amount of small molecule complement factor D (CFD) inhibitor of Formula I or Formula II, or a pharmaceutically acceptable salt thereof.

Abstract: A polymer compound including a repeating unit represented by Formula: wherein R1, R2, R3, R4, a1, a2, and a11 in Formula 1 are as defined in the specification.