Abstract: Disclosed are brain-targeted antibody delivery systems, methods of forming the systems, and methods of using the systems. The systems include hydrophilic nanogels based upon poly(ethylene glycol) copolymers. The nanogels can encapsulate an antibody for delivery to the brain and can include ligands for blood brain barrier (BBB) receptors on the surface, and as such, can utilize a systemic route of administration for delivery of the antibody to the brain and the eye. The systems can be utilized for systemic delivery routes to deliver the antibody to the brain side of the blood brain barrier and inside glial cells and degrade its corresponding protein. The systems can be utilized in treatment of neurodegenerative or retinal disorders.

Abstract: A rocking sensor device includes a primary bracket (1), a rotating shaft (2), rollers (3), magnets (4) and a magnetic induction sensor (5). The primary bracket (1) is rockably connected to the rotating shaft (2). The rollers (3) and the magnets (4) are mounted on both ends of the primary bracket (1) and their positions are symmetrical about the rotating shaft (2). The magnetic induction sensor (5) is mounted on the perimeter of the primary bracket (1) at a position such that it can sense rocking of the magnet (4) on any end with the primary bracket (1). The rocking sensor device is wear and corrosion resistant, and can be self-cleaning.