Abstract: The present disclosure provides an anti-tumor polypeptide Bax-BH3, a fluorescent polymeric nanomicelle, a preparation method and use thereof, belonging to the technical field of medicines. The anti-tumor polypeptide Bax-BH3 has an amino acid sequence set forth in SEQ ID No: 1; the fluorescent polymeric nanomicelle includes the anti-tumor polypeptide Bax-BH3 and a polymer carrier; and the polymer carrier is a block copolymer RGD-PHPMA-b-Poly(MMA-alt-(Rhob-MA)). In the present disclosure, the anti-tumor polypeptide Bax-BH3 has desirable biocompatibility and biological activity; and the fluorescent polymeric nanomicelle encapsulates the anti-tumor polypeptide Bax-BH3 by the block copolymer RGD-PHPMA-b-Poly(MMA-alt-(Rhob-MA)), with high encapsulation rate and drug loading, and good release performance.

Abstract: The present invention specifically relates to equipment and a method for preparing an aerogel thermal insulation mortar for a high-temperature kiln thereof. The equipment comprises a top box, a support frame platform, a processing mechanism, an agitation mechanism, a receiving mechanism and a docking mechanism, wherein the top box is provided with a partition frame capable of dividing an inner space thereof into a first material discharge cavity, a second material discharge cavity, a third material discharge cavity and a fourth material discharge cavity respectively; the receiving mechanism is mounted on an inner top of the support frame platform and docked with the top box; the docking mechanism is mounted on the receiving mechanism; an inner bottom of the support frame platform is provided with a collection box; one side of the top box is provided with a door panel.

Abstract: The present invention relates to a 2,3-dihydro-1H-pyrrolo[3,2-b]pyridine derivative, a preparation method therefor, and an application thereof, and in particular to an EGFR inhibitor having the structure of formula (I), a preparation method therefor, a pharmaceutical composition containing same, a use of same as an EGFR inhibitor, and a use of same in the treatment and/or prevention of cancers, tumors, or metastatic diseases at least partially related to EGFR exon 20 insertion or deletion mutations, especially a use in the treatment of hyperproliferative diseases and dysfunction in cell death induction. The definition of each substituent in formula (I) is the same as that in the description.

Abstract: The present disclosure relates to a performance testing device applicable to a metal fuel cell, and belongs to the field of metal fuel cells. Self-adaptive clamping equipment can be used for autonomously positioning and clamping galvanic piles with different sizes and shapes, and can be self-adaptively fixed according to the shapes. Sealing performance testing equipment is used for testing the sealing performance of the metal fuel cell through a testing pool. Discharge performance testing equipment is used for testing the discharge performance of the metal fuel cell. According to the performance testing device, two performances of sealing and discharging can be tested at the same time, perfusion of different electrolytes and measurement of galvanic piles composed of different numbers of single cells with different sizes can be realized, and the compatibility requirement of large-batch and multi-type cells delivered from a factory is met.

Abstract: Disclosed are a cabin pipeline using a super thermal insulation material and a preparation method thereof, comprising an electrically conductive inner pipe, an anti-corrosion coating coated on the electrically conductive inner pipe, a thermal insulation layer formed by a super thermal insulation material wound on the anti-corrosion coating, and a resin sealing layer coated on an outside of the thermal insulation layer. The electrically conductive inner pipe has excellent corrosion resistance to liquefied natural gas in the pipeline; the protective layer formed by the anti-corrosion coating and the resin sealing layer can prevent the electrically conductive inner pipe from being directly exposed to the environment due to long-term seawater infiltration or accidental damage of the outer layer, avoid electrochemical corrosion and further improve the corrosion resistance.

Abstract: The present invention relates to the technical field of fault location of distributed energy resources connected flexible DC distribution network, and disclosed a fault location method, system and application of bipolar short-circuit of two-level VSC-type photovoltaic-connected flexible DC distribution network, wherein, directions of positive currents of DC feeders during fault are used to locate a fault section; a bipolar short-circuit distance measurement model covering interactions and responses of systems is established according to equivalent circuits of transient periods; and fault location is done by obtaining a distance to fault with electric parameters and information of the fault.

Abstract: Provided is a steam jet multifunctional aircraft deicing vehicle with steam jet, includes a vehicle body, where a steam generating assembly is arranged in the vehicle body, and the steam generating assembly is connected with a steam conveying assembly. A moving assembly is rotatably connected above the vehicle body, and the moving assembly is rotatably connected with an execution assembly. The execution assembly includes a first spray head assembly and a second spray head assembly. The steam conveying assembly includes a first supercharger and a second supercharger arranged side by side, where an air outlet end of the first supercharger is communicated with one end of a first air outlet pipe, and an other end of the first air outlet pipe is communicated with spray heads of the second spray head assembly through a first air pipeline.

Abstract: Disclosed is a charging station capable of realizing mutual capacity aid, which comprises a plurality of charging units, a power bus and a mutual capacity aid bus. Each charging unit is powered by the power bus, and each charging unit provides mutual aid capacity for another charging unit through the mutual capacity aid bus or receives mutual aid capacity from other charging units through the mutual capacity aid bus. The charging station can realize rapid charging of electric vehicles, and can also realize mutual capacity aid.

Abstract: The application provides a driving circuit. The circuit includes: a segment display, including a plurality of light-emitting units; a controller, configured to generate a control instruction for the segment display according to a configuration signal; a digital driver, connected to the controller, and configured to generate a pulse driving signal according to the control instruction from the controller; and an amplification circuit, with one end being connected to the digital driver and the other end being connected to the plurality of light-emitting units of the segment display. The application also provides a magnetic sensing circuit and an electrical device. The magnetic sensing circuit includes a magnetic sensor, a sensing selection circuit, and a result representation circuit. A plurality of magnetic sensors are provided, and at least some of the plurality of magnetic sensors are capable of being connected to the sensing selection circuit by a sensing output terminal.

Abstract: Systems and methods are disclosed for conducting spinal cord stimulation or other neurostimulation and sensing evoked compound action potential (ECAP) signals. The sensed signals may be processed to isolate ECAP features from noise and/or interfering signals. The isolated ECAP features may be used to control neurostimulation therapy for the patient, such as to quantify or measure lead migration and adjust a neurostimulation therapy for the patient to account for an impact of any detected lead migration, or other purposes (e.g., to guide an implant procedure).

Abstract: Systems and methods may provide for a serial fluidic flow loop in a liquid-assisted air cooled thermal control system, in order to balance thermal gradients in the thermal control system.

Abstract: An apparatus for applying electrical stimulation to a target peripheral nerve in a subject includes a wearable structure configured to be worn on at least one of the subject's lower leg, foot, or ankle. A first stimulation electrode is mounted on the wearable structure at a first location on the wearable structure. A second stimulation electrode is mounted on the wearable structure at a second location on the wearable structure, different than the first location on the wearable structure. One or more recording electrodes are mounted on the wearable structure. The apparatus also includes a control unit for controlling the operation of the first stimulation electrode, the second stimulation electrode, and the one or more recording electrodes. The wearable is configured to position the first stimulation electrode on a medial side of the target peripheral nerve, and to position the second stimulation electrode on a lateral side of the target peripheral nerve.

Abstract: Disclosed are a power grid-friendly control method and system for a data center cooling system. The method includes: dividing an equipment room into a plurality of pieces of subspace in advance, with a plurality of servers and a cooling device comprised in each piece of subspace; obtaining total power consumption of the servers in each piece of subspace; performing priority sorting on the total power consumption of the servers in each piece of subspace; obtaining a real-time power supply energy consumption value of a power grid; determining, whether an energy supply is sufficient; and if the energy supply is sufficient, skipping turning off the cooling device in the subspace; or if the energy supply is not sufficient, turning off a cooling device, till it is determined that the energy supply is sufficient, thus minimizing impact of turning off the cooling system on stability.

Abstract: An immunosuppressant having the structure of formula (I), and a preparation method therefor and the use thereof are provided. The series of compounds can be widely used in the preparation of drugs for preventing and/or treating cancers or tumors, immune-related diseases and disorders, communicable diseases, infectious diseases or metabolic diseases mediated by PD-1/PD-L1 signal pathways, which drugs are expected to be developed into a new generation of PD-1/PD-L1 inhibitors.

Abstract: Systems and methods are disclosed for conducting spinal cord stimulation or other neurostimulation and sensing evoked compound action potential (ECAP) signals. The sensed signals may be processed to isolate ECAP features from noise and/or interfering signals. The isolated ECAP features may be used to control neurostimulation therapy for the patient and/or guide an implant procedure.

Abstract: Systems and methods are disclosed for conducting spinal cord stimulation or other neurostimulation and sensing evoked compound action potential (ECAP) signals. The sensed signals may be processed to isolate ECAP features from noise and/or interfering signals. The isolated ECAP features may be used to control neurostimulation therapy for the patient and/or guide an implant procedure.

Abstract: Systems and methods are disclosed for conducting spinal cord stimulation or other neurostimulation and sensing evoked compound action potential (ECAP) signals. The sensed signals may be processed to isolate ECAP features from noise and/or interfering signals. The isolated ECAP features may be used to control neurostimulation therapy for the patient and/or guide an implant procedure.

Abstract: Cooling of an information handling system can be provided liquid-assisted cooling apparatus with liquid. The liquid-assisted cooling apparatus may comprise a drip tray component positioned under a liquid-assisted cooling module having a cooling block, a heat exchanger, and piping connecting the cooling block and heat exchanger. The drip tray can collect fluid leaked by or from the liquid-assisted cooling module. The drip tray may include an absorbent material to contain the leaked fluid and/or a liquid sensor to detect the presence of fluid in the drip tray. The liquid sensor may be coupled to a controller configured to adjust operation of one or more electronic components cooled by the liquid-assisted cooling apparatus when fluid is determined to be present in the drip tray.

Abstract: This disclosure is directed to methods for treating an inflammatory disorder, comprising administering to a patient suffering from the disorder an effective amount of an inhibitor of an enzyme that regulates the S-palmitoylation of a pro-inflammatory transcription factor.

Abstract: An information handling system includes two or more heat-generating devices and a liquid-assisted air cooling (LAAC) assembly to cool at least some of the devices. The LAAC assembly includes a radiator, first and second pumps connected in series with the radiator. The LAAC assembly further includes first and second cold plates enclosing first and second CPUs or another suitable heat generating device. The first and second cold plates are connected in parallel between an inlet of the first pump and an outlet of the second pump. In this configuration, the serial connected pumps in combination with the parallel connected cold plates provide 1+1 pump redundancy while delivering cold coolant from the radiator outlet to both heat generating devices such that neither heat cold plate receives pre-heated coolant from the other cold plate.