Patents by Inventor Mingrao Ma

Mingrao Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN PAPILLOMAVIRUS TYPE 31 CHIMERIC PROTEIN AND USE THEREOF
    Publication number: 20240082382
    Abstract: The present invention relates to a human papillomavirus type 31 chimeric protein and a use thereof. Specifically, the present invention relates to a human papillomavirus chimeric protein, containing or being composed of an HPV31L1 protein or HPV31L1 protein mutant, and a polypeptide derived from an HPV73L2 protein and inserted into the HPV31L1 protein or HPV31L1 protein mutant, wherein the HPV31L1 protein is as shown in SEQ ID No. 1, and the HPV73L2 protein is as shown in SEQ ID No. 2.
    Type: Application
    Filed: September 26, 2021
    Publication date: March 14, 2024
    Inventors: Xuemei Xu, Yaru Hao, Ting Zhang, Mingrao Ma
  • HUMAN PAPILLOMAVIRUS TYPE 58 CHIMERIC PROTEIN AND USE THEREOF
    Publication number: 20240058432
    Abstract: Provided are an HPV chimeric protein and a use thereof. The HPV chimeric protein of the present invention comprises an HPV58 L1 protein or a mutant thereof and a polypeptide derived from a HPV16 L2 protein and inserted into a surface region of the HPV58 L1 protein or the mutant thereof, or consists of the polypeptide, wherein an amino acid sequence of the HPV58 L1 protein is as shown in SEQ ID No. 1 and an amino acid sequence of the HPV16 L2 protein is as shown in SEQ ID No. 2.
    Type: Application
    Filed: September 26, 2021
    Publication date: February 22, 2024
    Applicant: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
    Inventors: Xuemei XU, Zhirong WANG, Mingrao MA, Ting ZHANG
  • MODIFIED HUMAN PAPILLOMAVIRUS TYPE 52 L1 PROTEIN AND USE THEREOF
    Publication number: 20240002447
    Abstract: The present application relates to a modified human papillomavirus (HPV) type 52 L1 protein and a use thereof. Specifically, the present application relates to a HPV type 52 L1 protein, a nucleotide encoded thereby, a carrier comprising the nucleotide, a cell comprising the carrier, a pentamer or virus-like particle consisting of the HPV-52 L1 protein, a vaccine comprising the pentamer or virus-like particle and a vaccine adjuvant, and a use thereof in the prevention of HPV infections and HPV infection-related diseases.
    Type: Application
    Filed: September 26, 2021
    Publication date: January 4, 2024
    Inventors: Xuemei Xu, Mingrao Ma, Yaru Hao, Ting Zhang, Zhirong Wang