Abstract: The present invention provides novel methods for anti-aging, especially ameliorating or preventing skin aging, cellular senescence, or photoaging through inhibiting progerin in a mammal. The method includes administration to the mammal a composition including an effective amount of dihydroberberine or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof. The present invention also provides a composition including an effective amount of dihydroberberine or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof, for anti-aging, especially ameliorating or preventing skin aging, cellular senescence, or photoaging through inhibiting progerin in a mammal.

Abstract: Among others, the present invention provides methods and compositions for mimicking one or more biological benefits of caloric restriction in a mammal, including administrating to the mammal an effective amount of ?-aminoisobutyric acid, an analog, metabolite or derivative thereof, or a pharmaceutically acceptable salt, ester, polymer, acid thereof.

Abstract: Among others, the present invention provides methods and compositions for controlling blood glucose or weight, including a combination of (i) a therapeutically effective amount of berberine (BBR), or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof, including dihydroberberine (DHB); and (ii) vitamin B12. The combination effectively ameliorates BBR or DHB side effects, including VB12 reduction, gastrointestinal discomfort, and slowed bowel movements, by promoting transcobalamin II receptors synthesis, decreasing homocysteine levels and maintaining intestinal balance, including short chain fatty acids content, gut microbiota diversity and richness.