Patents by Inventor Mingshi Dai

Mingshi Dai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aryl sulfonamides useful as inhibitors of chemokine receptor activity
    Patent number: 8063222
    Abstract: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, X, Z, R2, X1, Ar, n, R3 and R4 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: November 22, 2011
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Mingshi Dai, Bing Guan, Robert A. Bennett, Douglas F. Burdi, Shomir Ghosh, Gang Li, Charles A. Minor, Tracy J. Jenkins
  • Aryl sulfonamides useful as inhibitors of chemokine receptor activity
    Publication number: 20090275556
    Abstract: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, X, Z, R2, X1, Ar, n, R3 and R4 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.
    Type: Application
    Filed: August 27, 2008
    Publication date: November 5, 2009
    Inventors: Mingshi Dai, Bing Guan, Roert A. Bennett, Douglas F. Burdi, Shomir Ghosh, Gang Li, Charles Minor, Tracy J. Jenkins
  • Aryl sulfonamides useful as inhibitors of chemokine receptor activity
    Patent number: 7491827
    Abstract: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, X, Z, R2, X1, Ar, n, R3 and R4 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: February 17, 2009
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Mingshi Dai, Bing Guan, Robert A. Bennett, Douglas F. Burdi, Shomir Ghosh, Gang Li, Charles Minor, Tracy J. Jenkins
  • Melanocortin-4 receptor binding compounds and methods of use thereof
    Publication number: 20080269217
    Abstract: Provided are MC4-R binding compounds of the formula XVII: wherein L2 is a linker group, and P1, P2, P3, P4, Z1, Z2, Z3, Z4, Z5, t, s, and R are as described in the specification. Methods of using the compounds to treat MC4-R associated disorders, such as disorders associated with weight loss, are also provided.
    Type: Application
    Filed: May 1, 2008
    Publication date: October 30, 2008
    Applicant: Ore Pharmaceuticals, Inc.
    Inventors: Tricia J. Vos, Michael E. Solomon, Christopher F. Claiborne, Martin P. Maguire, Mingshi Dai, Michael Patane, Thoma H. Marsilje
  • CCR8 inhibitors
    Patent number: 7378525
    Abstract: Disclosed are CCR8 inhibitors represented by Structural Formulas (I): The variables in Structural Formula (I) are described herein. Also disclosed are methods of treating a subject with a CCR8 mediated condition, especially asthma, by administering one of the disclosed CCR8 inhibitors to the subject.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: May 27, 2008
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Bing Guan, Charles Minor, Mingshi Dai, Shomir Ghosh, Tracy J. Jenkins, Gang Li, Douglas F. Burdi, Robert A. Bennett
  • Melanocortin-4 receptor binding compounds and methods of use thereof
    Patent number: 7375125
    Abstract: Provided are MC4-R binding compounds of the formula XVII: wherein L2 is a linker group, and P1, P2, P3, P4, Z1, Z2, Z3, Z4, Z5, t, s, and R are as described in the specification. Methods of using the compounds to treat MC4-R associated disorders, such as disorders associated with weight loss, are also provided.
    Type: Grant
    Filed: June 16, 2003
    Date of Patent: May 20, 2008
    Assignee: Ore Pharmaceuticals, Inc.
    Inventors: Tricia J. Vos, Michael E. Solomon, Christopher F. Claiborne, Martin P. Maguire, Mingshi Dai, Michael Patane, Thomas H. Marsilje
  • CCR8 inhibitors
    Patent number: 7329755
    Abstract: Disclosed is an inhibitor of CCR8 that is represented by Structural Formula (I): Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a CCR8 inhibitor represented by Structural Formula (I). Also disclosed is a method of treating inflammatory disorders in a subject by administering a CCR8 inhibitor to the subject.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: February 12, 2008
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Mingshi Dai, Tracy J. Jenkins, Bing Guan, Shomir Ghosh, Charles Minor
  • Aryl sulfonamides useful as inhibitors of chemokine receptor activity
    Publication number: 20050085518
    Abstract: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, X, Z, R2, X., Ar, n, R3 and R4 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.
    Type: Application
    Filed: July 14, 2004
    Publication date: April 21, 2005
    Inventors: Mingshi Dai, Bing Guan, Robert Bennett, Douglas Burdi, Shomir Ghosh, Gang Li, Charles Minor, Tracy Jenkins
  • CCR8 inhibitors
    Publication number: 20040224978
    Abstract: Disclosed is an inhibitor of CCR8 that is represented by Structural Formula (I): 1
    Type: Application
    Filed: December 23, 2003
    Publication date: November 11, 2004
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Mingshi Dai, Tracy J. Jenkins, Bing Guan, Shomir Ghosh, Charles Minor
  • CCR8 Inhibitors
    Publication number: 20040209948
    Abstract: Disclosed are CCR8 inhibitors represented by Structural Formulas (I): 1
    Type: Application
    Filed: December 23, 2003
    Publication date: October 21, 2004
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Bing Guan, Charles Minor, Mingshi Dai, Shomir Ghosh, Tracy J. Jenkins, Gang Li, Douglas F. Burdi, Robert A. Bennett
  • Melanocortin-4 receptor binding compounds and methods of use thereof
    Publication number: 20040082779
    Abstract: Provided are MC4-R binding compounds of the formula XVII: 1
    Type: Application
    Filed: June 16, 2003
    Publication date: April 29, 2004
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Tricia J. Vos, Michael E. Solomon, Christopher F. Claiborne, Martin P. Maguire, Mingshi Dai, Michael Patane, Thomas H. Marsilje
  • Melanocortin-4 receptor binding compounds and methods of use thereof
    Patent number: 6699873
    Abstract: MC4-R binding compounds of the formula: B—Z—E  (I) wherein B is an anchor moiety, Z is a central moiety, and E is a MC4-R interacting. moiety are discussed. Methods of using the compounds to treat MC4-R associated disorders, such as disorders associated with weight loss, are also discussed.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: March 2, 2004
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Martin P. Maguire, Mingshi Dai, Tricia J. Vos