Abstract: The present invention relates to the field of biomedicine, and discloses a pyrazolopyrimidine compound, a pharmaceutical composition, and an application therefor, the oxygen-containing substituted pyrazolopyrimidine compound having the structure shown in formula (I). The oxygen-containing substituted pyrazolopyrimidine compound having the structure shown in formula (I) provided in the present invention or a pharmaceutically acceptable salt, a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite, or a prodrug thereof demonstrate excellent inhibitory activity against TRK kinase, and demonstrate good anti-tumour activity at the animal level.

Abstract: Disclosed herein are a duck hepatitis A virus type 3 (DHAV-3) mutant CH-P60-117C and a construction method thereof. The DHAV-3 mutant CH-P60-117C is constructed by mutating A at position 117 of 5?-UTR of the genome of the DHAV-3 virulent strain to C; mutating T at position 1142 to A to mutate tyrosine-164 of VP0 protein of the parent strain to asparagine; and mutating C at position 4334 to A so that leucine-71 of the viral protein 2C of the parent strain is mutated to isoleucine.

Abstract: Disclosed herein are a duck hepatitis A virus type 3 (DHAV-3) mutant CH-P60-117C and a construction method thereof. The DHAV-3 mutant CH-P60-117C is constructed by mutating A at position 117 of 5?-UTR of the genome of the DHAV-3 virulent strain to C; mutating T at position 1142 to A to mutate tyrosine-164 of VP0 protein of the parent strain to asparagine; and mutating C at position 4334 to A so that leucine-71 of the viral protein 2C of the parent strain is mutated to isoleucine.

Abstract: One embodiment of the present invention provides a data transmission method, including: performing a serial-to-parallel conversion for input date stream, obtaining 4 parallel data streams and partitioning the 4 parallel data streams into 2 groups; performing trellis encoding for one group and selecting one basic codeword subset from all basic codeword subsets according to the trellis encoding output; performing trellis encoding for one data stream in the other group and selecting one phase subset from all phase subsets according to the trellis encoding output, and selecting a phase value from the selected phase subset according to another data stream in the other group; rotating the codeword selected from the basic codeword subset by the selected phase value and obtaining and transmitting an output codeword to a data receive-side. One embodiment of the present invention also includes another data transmission method and two data transmission apparatuses.