Abstract: The present invention relates to a knowledge-graph extrapolating method and system based on multi-layer perception, the method comprising: using relational graph convolutional network encoders to learn embedding representations, and capturing dynamic evolution of a fact; designing emerging task processing units to construct multiple layers of entity sets, and assigning a matching historical relevance; classifying prediction tasks into different reasoning scenes, and connecting them to the corresponding processing unit for partition of entity sets; and using a multi-class task solving method to acquire predicted probability distributions of target entities, and taking the highest one as a prediction answer, so as to accomplish extrapolation of a temporal knowledge graph, wherein the prediction tasks are classified into different reasoning scenes according to whether it contains any entity or relation that has never appeared historically.

Abstract: The present invention provides a bacterium and a method for the biological production of Heliotropin by the fermemtation of safrole. In one aspect of the present invention, a process for the conversion of safrole to Heliotropin is achieved by the use of a bacterial strain of Serratia liquefaciens ZMT-1 (CCTCC M 2016170). The production method comprises the steps of seeding the Serratia liquefaciens culture in the presence of oxygen for 24-36 hours, transforming the safrole substrate for 24-48 hours with 0.5-3 g/L substrate concentration, and reaching the Heliotropin concentration of 160-524 mg/L. The present invention reports, for the first time, on a method for producing the high concentration of Heliotropin by using the Serratia liquefaciens ZMT-1 strain or the enzyme extracted from the strain.

Abstract: The present invention provides a bacterium and a method for the biological production of Heliotropin by the fermemtation of safrole. In one aspect of the present invention, a process for the conversion of safrole to Heliotropin is achieved by the use of a bacterial strain of Serratia liquefaciens ZMT-1 (CCTCC M 2016170). The production method comprises the steps of seeding the Serratia liquefaciens culture in the presence of oxygen for 24-36 hours, transforming the safrole substrate for 24-48 hours with 0.5-3 g/L substrate concentration, and reaching the Heliotropin concentration of 160-524 mg/L. The present invention reports, for the first time, on a method for producing the high concentration of Heliotropin by using the Serratia liquefaciens ZMT-1 strain or the enzyme extracted from the strain.

Abstract: Methods and computer program products for quantitative three-dimensional (“3D”) image correction in optical coherence tomography. Using the methods and computer program products, index interface (refracting) surfaces from the raw optical coherence tomography (“OCT”) dataset from an OCT system can be segmented. Normal vectors or partial derivatives of the curvature at a refracting surface can be calculated to obtain a refracted image voxel. A new position of each desired refracted image voxel can be iteratively computed. New refracted corrected voxel positions to an even sampling grid can be interpolated to provide corrected image data. In some embodiments, clinical outputs from the corrected image data can be computed.

Abstract: A probe for an optical coherence tomography system according to an embodiment of the current invention includes a sheath having a proximal end and a distal end and defining a lumen therein, an optical fiber disposed at least partially within the lumen of said sheath, and a sapphire lens attached to the distal end of the sheath to form a fluid-tight seal to prevent fluid from entering the lumen of said sheath. The optical fiber has an end arranged in an optical path with the sapphire lens to provide optical coupling between the sapphire lens and the optical fiber.

Abstract: Methods and computer program products for quantitative three-dimensional (“3D”) image correction in optical coherence tomography. Using the methods and computer program products, index interface (refracting) surfaces from the raw optical coherence tomography (“OCT”) dataset from an OCT system can be segmented. Normal vectors or partial derivatives of the curvature at a refracting surface can be calculated to obtain a refracted image voxel. A new position of each desired refracted image voxel can be iteratively computed. New refracted corrected voxel positions to an even sampling grid can be interpolated to provide corrected image data. In some embodiments, clinical outputs from the corrected image data can be computed.

Abstract: A probe for an optical coherence tomography system according to an embodiment of the current invention includes a sheath having a proximal end and a distal end and defining a lumen therein, an optical fiber disposed at least partially within the lumen of said sheath, and a sapphire lens attached to the distal end of the sheath to form a fluid-tight seal to prevent fluid from entering the lumen of said sheath. The optical fiber has an end arranged in an optical path with the sapphire lens to provide optical coupling between the sapphire lens and the optical fiber.

Abstract: An optical coherence tomography (OCT) system for real-time surgical guidance includes an optical source, an optical fiber configured to be optically coupled to the optical source, a plurality of OCT sensor heads configured to be optically coupled to the optical fiber, an optical detector configured to be optically coupled to the optical fiber, a signal processor configured to communicate with the optical detector to receive detected signals therefrom, and a display system configured to receive OCT image signals from the signal processor and to display an OCT image of at least a portion of a surgical region of interest in real time to provide surgical guidance.

Abstract: In accordance with this disclosure, methods, systems, and computer readable media for synthetic wavelength-based phase unwrapping in optical coherence tomography are provided. Synthetic wavelength phase unwrapping can be applied to OCT data and can correctly resolve sample motions that are larger than ?o/2. A method for phase unwrapping of an OCT signal can include acquiring raw OCT signal data, interpolating and processing the OCT signal data to obtain a DC spectrum, comparing the raw OCT signal data to the DC spectrum to generate an interference signal, applying Gaussian windows to the interference signal to generate a two separate signals, extracting phase information from the two signals, and comparing the phase information of the two signals to produce unwrapped phase data. A value of 2? can be added to the phase data if the difference between the phase information of the two signals is less than zero.

Abstract: Methods and computer program products for quantitative three-dimensional (“3D”) image correction in optical coherence tomography. Using the methods and computer program products, index interface (refracting) surfaces from the raw optical coherence tomography (“OCT”) dataset from an OCT system can be segmented. Normal vectors or partial derivatives of the curvature at a refracting surface can be calculated to obtain a refracted image voxel. A new position of each desired refracted image voxel can be iteratively computed. New refracted corrected voxel positions to an even sampling grid can be interpolated to provide corrected image data. In some embodiments, clinical outputs from the corrected image data can be computed.

Abstract: In accordance with this disclosure, methods, systems, and computer readable media for synthetic wavelength-based phase unwrapping in optical coherence tomography are provided. Synthetic wavelength phase unwrapping can be applied to OCT data and can correctly resolve sample motions that are larger than ?o/2. A method for phase unwrapping of an OCT signal can include acquiring raw OCT signal data, interpolating and processing the OCT signal data to obtain a DC spectrum, comparing the raw OCT signal data to the DC spectrum to generate an interference signal, applying Gaussian windows to the interference signal to generate a two separate signals, extracting phase information from the two signals, and comparing the phase information of the two signals to produce unwrapped phase data. A value of 2? can be added to the phase data if the difference between the phase information of the two signals is less than zero.

Abstract: Methods, systems, and computer program products for removing undesired artifacts in Fourier domain optical coherence tomography (FDOCT) systems using integrating buckets are disclosed. According to one aspect, a method includes introducing a variable phase delay between a reference arm and a sample arm of an FDOCT interferometer using sinusoidal phase modulation. Further, the method includes acquiring an interferometric intensity signal using an integrating buckets technique. The method also includes resolving the interferometric intensity signal to remove undesired artifacts.

Abstract: An exterior electrochromic reflective mirror element for a vehicular exterior rearview mirror assembly comprises an electrochromic cross-linked polymeric solid film disposed between a first substrate and a second substrate. The electrochromic cross-linked polymeric solid film contacts a transparent conductive layer of the first substrate and a conductive layer comprising a metallic reflective layer of the second substrate. A visual indicator display is disposed to the rear of said second substrate and is part of a blind spot detection and display system and is actuated to emit light responsive to a detection of another overtaking vehicle in a side lane. Light emitted by the visual indicator display passes through the second substrate, through the electrochromic cross-linked polymeric solid film and through the first substrate to be viewed by a driver of the vehicle equipped with the exterior electochromic reflective mirror element.

Abstract: An electrochromic mirror device suitable for use in a vehicle comprises a first transparent substrate having a transparent conductive layer on a surface thereof and a second substrate having a conductive layer on a surface thereof. The conductive layer of the first substrate opposes the second conductive layer of the second substrate in a spaced-apart relationship thereby forming an interpane distance between the substrates. A boundary seal is interposed between the first and second substrates spacing apart the substrates and forming a cavity wherein the interpane distance is at least about 10 microns. An electrochromic cross-linked polymeric solid film is disposed within the cavity. The electrochromic cross-linked solid polymeric film is formed from an electrochromic monomer composition that includes at least one cathodic electrochromic compound. The second conductive layer comprises a metallic reflective layer.

Abstract: An electrochromic mirror device suitable for use in a vehicle comprises a first transparent substrate having a transparent conductive layer on a surface thereof and a second substrate having a conductive layer on a surface thereof. The conductive layer of the first substrate opposes the second conductive layer of the second substrate in a spaced-apart relationship thereby forming an interpane distance between the substrates. A boundary seal is interposed between the first and second substrates spacing apart the substrates and forming a cavity wherein the interpane distance is at least about 10 microns. An electrochromic cross-linked polymeric solid film is disposed within the cavity. The electrochromic cross-linked solid polymeric film is formed from an electrochromic monomer composition that includes at least one cathodic electrochromic compound. The second conductive layer comprises a metallic reflective layer.

Abstract: The present invention relates to electrochromic polymeric solid films, manufacturing electrochromic devices using such solid films and processes for making such solid films and devices. The electrochromic polymeric solid films of the present invention exhibit beneficial properties and characteristics, especially when compared to known electrochromic media. The electrochromic polymeric solid films are transformed in situ from a low viscosity electrochromic monomer composition by exposure to electromagnetic radiation, and in so doing minimum shrinkage occurs. The electrochromic polymeric solid films of the present invention also perform well under prolonged coloration, outdoor weathering and all-climate exposure, and provide an inherent safety aspect not known to electrochromic media heretofore.