Abstract: A pharmaceutical composition is provided, including a protein arginine methyltransferase 5 (PRMT5) inhibitor and an epidermal growth factor receptor (EGFR) inhibitor. The pharmaceutical composition can be used to treat various cancers, including solid tumors. The combination product can be used to treat any number of diseases related to PRMT5 and/or EGFR.

Abstract: A pharmaceutical composition is provided, including a pharmaceutical composition or a combined pharmaceutical composition of a protein arginine methyltransferase 5 (PRMT5) inhibitor and a PD-1/PD-L1 inhibitor. The PD-1/PD-L1 inhibitor is a small molecule compound, nucleic acid, peptide, protein, antibody, peptide antibody, double antibody, mini antibody, single chain fragment variable or a fragment or variant or any combination thereof. The pharmaceutical composition can be used to treat various cancers, including solid tumors.

Abstract: Discloses an ?-amylase mutant and a use thereof. Compared with a parental ?-amylase with an amino acid sequence shown in SEQ ID NO: 1, the ?-amylase mutant has a disulfide bond site pair mutation, the disulfide bond site pair has the following characteristics: i. the disulfide bond site pair is not within 5? range of an active site of the ?-amylase mutant; ii. a difference value in amino acid site numbers is greater than 10; iii. a distance between SG atoms of two cysteines forming a disulfide bond is within 5?; and iv. a Chi3 angle is 60°<Chi3<120° or ?60°>Chi3>?120°. The heat resistance and/or acid resistance of the ?-amylase mutants provided in the present disclosure have been significantly improved.

Abstract: Embodiments of the present disclosure relate to a data processing method and apparatus, a device, and a medium.

Abstract: An image super-resolution method includes: performing feature extraction on an image to be subjected to super-resolution, to obtain a first image feature; processing the first image feature through a feature processing module to obtain a second image feature, where the feature processing module includes: a feature refinement unit that includes at least one set of first convolutional layer and first activation function layer that are connected in series and is configured to process an input feature of the feature processing module; a feature fusion unit configured to perform additive fusion on the input feature of the feature processing module and an output feature of the feature refinement unit; and an attention unit configured to process an output feature of the feature fusion unit to obtain an output feature of the feature processing module; and generating, based on the first image feature and the second image feature, a super-resolution image.

Abstract: An enzyme-linked immunosorbent assay (ELISA) method and a monoclonal antibody for giant panda relaxin-3 (RLN3) are provided. The method includes: conducting ELISA with an anti-giant panda RLN3 monoclonal antibody as a coating antibody and an anti-RLN3 polyclonal antibody as a labeling antibody, where the anti-giant panda RLN3 monoclonal antibody is secreted by a hybridoma cell line RLN-3; and the hybridoma cell line RLN-3 was deposited in the China Center for Type Culture Collection (CCTCC) of Wuhan University, Wuhan, China on Jan. 7, 2021, with an accession number of CCTCC NO: C202129. In addition, an ELISA method for detecting RLN3 in giant panda urine is developed, in which a prepared anti-giant panda RLN3 monoclonal antibody is used as a coating antibody and an anti-giant panda RLN3 polyclonal antibody is used as a labeling antibody. The method can monitor a change in giant panda RLN3 timely by determining giant panda RLN3.

Abstract: An enzyme-linked immunosorbent assay (ELISA) method and a monoclonal antibody for giant panda relaxin-3 (RLN3) are provided. The method includes: conducting ELISA with an anti-giant panda RLN3 monoclonal antibody as a coating antibody and an anti-RLN3 polyclonal antibody as a labeling antibody, where the anti-giant panda RLN3 monoclonal antibody is secreted by a hybridoma cell line RLN-3; and the hybridoma cell line RLN-3 was deposited in the China Center for Type Culture Collection (CCTCC) of Wuhan University, Wuhan, China on Jan. 7, 2021, with an accession number of CCTCC NO: C202129. In addition, an ELISA method for detecting RLN3 in giant panda urine is developed, in which a prepared anti-giant panda RLN3 monoclonal antibody is used as a coating antibody and an anti-giant panda RLN3 polyclonal antibody is used as a labeling antibody. The method can monitor a change in giant panda RLN3 timely by determining giant panda RLN3.

Abstract: A method for remanufacturing an ultra-large copper nut includes steps of: step (1) coarsening treatment; step (2) purifying treatment; step (3) detecting a material of the ultra-large copper nut; step (4) sleeving a thermal insulation device; step (5) preheating the ultra-large copper nut; step (6) melting-deposition shaping; step (7) post-processing; and step (8) detecting. The method of the present invention simultaneously utilizes water, electricity, gas, fire and machine and performs melting-deposition on materials by simultaneously supplying water, electricity, gas, fire and machine according to the designed requirements. The method of the present invention solves problems of large thickness abrasion and remediation of fracture components. The method of the present invention is capable of preventing the ultra-large copper nut from deformation and collapse and is a feasible remanufacturing for decreasing the huge economic loss caused by damages of expensive ultra-large of nonferrous metals.

Abstract: A method for remanufacturing an ultra-large copper nut includes steps of: step (1) coarsening treatment; step (2) purifying treatment; step (3) detecting a material of the ultra-large copper nut; step (4) sleeving a thermal insulation device; step (5) preheating the ultra-large copper nut; step (6) melting-deposition shaping; step (7) post-processing; and step (8) detecting. The method of the present invention simultaneously utilizes water, electricity, gas, fire and machine and performs melting-deposition on materials by simultaneously supplying water, electricity, gas, fire and machine according to the designed requirements. The method of the present invention solves problems of large thickness abrasion and remediation of fracture components. The method of the present invention is capable of preventing the ultra-large copper nut from deformation and collapse and is a feasible remanufacturing for decreasing the huge economic loss caused by damages of expensive ultra-large of nonferrous metals.