Patents by Inventor Mingxing Duan

Mingxing Duan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8465757
    Abstract: The present invention relates to a nanoemulsion of resveratrol-phospholipid complex, method for preparing the same and applications thereof. The nanoemulsion comprises: 1 part by weight of resveratrol, 2˜30 parts by weight of phospholipid, and 30˜490 parts by weight of an aqueous solution of polyol with the polyol concentration being 30˜99 percent by weight. The method comprises the steps of: a resveratrol-phospholipid complex being prepared, then the complex being dispersed into the aqueous solution of polyol to form a dispersion, and a nanoemulsion with particle size less than 200 nm being formed by homogenization of the dispersion with a high pressure homogenizer or Microfluidizer homogenizer. The nanoemulsion is miscible with water at any ratio, has high stability and high bioavailability, and thus can be widely used for preparation of cosmetics, pharmaceuticals or healthcare products.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: June 18, 2013
    Assignees: Tsinghua University, Jiangsu Longliqi Bioscience Co. Ltd.
    Inventors: Mingxing Duan, Huafeng Zhou, Zemin Yan
  • Publication number: 20100297199
    Abstract: The present invention relates to a nanoemulsion of resveratrol-phospholipid complex, method for preparing the same and applications thereof. The nanoemulsion comprises: 1 part by weight of resveratrol, 2˜30 parts by weight of phospholipid, and 30˜490 parts by weight of an aqueous solution of polyol with the polyol concentration being 30˜99 percent by weight. The method comprises the steps of: a resveratrol-phospholipid complex being prepared, then the complex being dispersed into the aqueous solution of polyol to form a dispersion, and a nanoemulsion with particle size less than 200 nm being formed by homogenization of the dispersion with a high pressure homogenizer or Microfluidizer homogenizer. The nanoemulsion is miscible with water at any ratio, has high stability and high bioavailability, and thus can be widely used for preparation of cosmetics, pharmaceuticals or healthcare products.
    Type: Application
    Filed: September 29, 2009
    Publication date: November 25, 2010
    Inventors: Mingxing Duan, Huafeng Zhou, Zemin Yan
  • Patent number: 7018980
    Abstract: The invention relates to the method for preparation of orally administrated insulin oil formulation comprising: dissolving an amount of insulin in an acidic aqueous buffer(A); adding A to liquid surfactant, the HLB value of which is between 10 and 20, with agitation to form a homogeneous solution(B); adding B to an oil, the HLB value of which is between 0 and 10, with agitation to form oil formulation. This invention has a simple process with low cost. After orally administrated, the formulation prepared with the process of the invention can resist the gastrointestinal degradation by digestive enzymes, and is easily absorbed for hypoglycemic effect.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: March 28, 2006
    Assignees: Tsinghua University, Fosse Bio-Engineering Development, Ltd.
    Inventors: Changxue Zheng, Mingxing Duan, Hong Ma, Housheng Zhong
  • Publication number: 20040097410
    Abstract: The invention relates to the method for preparation of orally administrated insulin oil formulation comprising: dissolving an amount of insulin in an acidic aqueous buffer (A); adding A to liquid surfactant, the HLB value of which is between 10 and 20, with agitation to form a homogeneous solution (B); adding B to an oil, the HLB value of which is between 0 and 10, with agitation to form oil formulation. This invention has a simple process with low cost. After orally administrated, the formulation prepared with the process of the invention can resist the gastrointestinal degradation by digestive enzymes, and is easily absorbed for hypoglycemic effect.
    Type: Application
    Filed: October 8, 2003
    Publication date: May 20, 2004
    Inventors: Changxue Zheng, Mingxing Duan, Hong Ma, Houseng Zhong