Patents by Inventor mingxing Ke

mingxing Ke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecular imaging method for evaluating liver regeneration capacity after ALPPS operation
    Patent number: 11123033
    Abstract: Disclosed is a molecular imaging method for evaluating liver regeneration ability after ALPPS. The method includes steps of: 1) preparing a VX2 rabbit liver cancer model; 2) performing ALPPS for the VX2 rabbit liver cancer model; 3) synthesizing 18F-Fluoromethylcholine (18F-Methylcholine, 18F-FCH); 4) PET/CT imaging and data processing for 18F-FCH. The disclosure is the first to propose the use of 18F-FCH PET/CT to monitor the proliferative capacity of residual liver, and further indirectly reflect the increased ability of cell membrane synthesis on the basis that 18F-FCH has higher choline metabolism in residual liver tissue, so that the liver regeneration ability after ALPPS is evaluated by the molecular imaging method, thereby providing important new ideas for the clinical selection of ALPPS to choose the best time for second-stage surgery.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: September 21, 2021
    Assignee: Harbin Medical University
    Inventors: Xilin Sun, Zhen Quan, Ruifeng Wang, Kai Wang, Lili Yang, Zunyu Xiao, Yang Liu, Zhaoguo Han, Xiang Liu, Mingxing Ke
  • MOLECULAR IMAGING METHOD FOR EVALUATING LIVER REGENERATION CAPACLITY AFTER ALPPS OPERATION
    Publication number: 20210015439
    Abstract: Disclosed is a molecular imaging method for evaluating liver regeneration ability after ALPPS. The method includes steps of: 1) preparing a VX2 rabbit liver cancer model; 2) performing ALPPS for the VX2 rabbit liver cancer model; 3) synthesizing 18F-Fluoromethylcholine (18F-Methylcholine, 18F-FCH); 4) PET/CT imaging and data processing for 18F-FCH. The disclosure is the first to propose the use of 18F-FCH PET/CT to monitor the proliferative capacity of residual liver, and further indirectly reflect the increased ability of cell membrane synthesis on the basis that 18F-FCH has higher choline metabolism in residual liver tissue, so that the liver regeneration ability after ALPPS is evaluated by the molecular imaging method, thereby providing important new ideas for the clinical selection of ALPPS to choose the best time for second-stage surgery.
    Type: Application
    Filed: September 30, 2020
    Publication date: January 21, 2021
    Inventors: xinlin Sun, zhen Quan, Ruifeng Wang, kai Wang, lili Yang, zunyu Xiao, yang Liu, zhaoguo Han, xiang Liu, mingxing Ke