Abstract: Provided are a small molecule compound combination for reprogramming digestive tract derived epithelial cells to endodermal stem/progenitor cells, a reprogramming method and an application. Human gastric epithelial cells (hGECs) are used as initiating cells, human gastric subepithelial myofibroblasts (aGSEMFs) are used as a trophoblast, a compound combination having all or a plurality of FBP, Bay K 8644, Bix01294, SB431542 or A813-01, VPA, RG108, PD0325901 and PS48 including SB or A83 is used to reprogram digestive tract derived epithelial cells to endodermal stem/progenitor cells, and the endodermal stem/progenitor cells can be used for inducing differentiation towards liver cells, pancreatic beta cells and intestinal cells.

Abstract: Provided are a small molecule compound combination for reprogramming digestive tract derived epithelial cells to endodermal stem/progenitor cells, a reprogramming method and an application. Human gastric epithelial cells (hGECs) are used as initiating cells, human gastric subepithelial myofibroblasts (aGSEMFs) are used as a trophoblast, a compound combination having all or a plurality of FBP, Bay K 8644, Bix01294, SB431542 or A813-01, VPA, RG108, PD0325901 and PS48 including SB or A83 is used to reprogram digestive tract derived epithelial cells to endodermal stem/progenitor cells, and the endodermal stem/progenitor cells can be used for inducing differentiation towards liver cells, pancreatic beta cells and intestinal cells.

Abstract: A mechanical locking device in the kit form for the prevention of automotive vehicle theft by locking the gearshift control lever to the park position of this vehicle which comprises parts to form basically a clamp attached permanently to the lower portion of the lever, regardless of the size, shape, tilt angle and clearance of such lever, and a yoke and latching member capable of being lowered at least in part into and locked securely to the slot structure of various widths and lengths whereby the control lever is operated to prevent the movement of such control lever.

Abstract: An anti-theft lock for the permanent attachment to a gear shifting lever of an automobile comprising a L-shaped elbow member which can be placed into a slot for gear shifting movement of such lever and locked therein to fill-up same and therefore blocking the movement of the gear shifting lever and preventing the operation of the vehicle, a body member comprising a pair of parallel passages adapted to accommodate a portion of such gear shifting lever securely thereunto and the vertical rod portion of the L-shaped elbow regulating its movement therein, and means associated with the vertical rod of the elbow and the body member to lock the elbow for the anti-theft function and unlock and arrest same for the normal operation of the vehicle.