Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: A temperature sensing device includes a substrate, a first reflective module, a first window cover, and a dual thermopile sensor. The first reflective module is disposed on the substrate, including a first mirror chamber with a narrow field of view (FOV), and the first reflective module focuses a thermal radiation from measured object to a first image plane in the first mirror chamber. The first window cover is disposed on the first reflective module, and the first window cover allows a selected band of the thermal radiation to pass through. The dual thermopile sensor is disposed on the substrate and located in the first mirror chamber, and the dual thermopile sensor senses a temperature data from the first image plane. Additional second reflective module, LED source plus pin hole with same FOV of dual thermopile sensor can illuminate the measured object for ease of placement of object to be heated.

Abstract: Embodiments of the present disclosure provide a method for forming semiconductor device structures. The method includes forming a fin structure having a stack of semiconductor layers comprising first semiconductor layers and second semiconductor layers alternatingly arranged, forming a sacrificial gate structure over a portion of the fin structure, removing the first and second semiconductor layers in a source/drain region of the fin structure that is not covered by the sacrificial gate structure, forming an epitaxial source/drain feature in the source/drain region, removing portions of the sacrificial gate structure to expose the first and second semiconductor layers, removing portions of the second semiconductor layers so that at least one second semiconductor layer has a width less than a width of each of the first semiconductor layers, forming a conformal gate dielectric layer on exposed first and second semiconductor layers, and forming a gate electrode layer on the conformal gate dielectric layer.

Abstract: The present invention provides a method of evaluating drug resistance in hormone therapy including the following steps. Firstly, a primary level of TRBP in a subject is measured, and an effective amount of tamoxifen, an active form of tamoxifen or an analogous of tamoxifen is provided to the subject. Then, a level of TRBP in the subject is measured after providing tamoxifen, the active form of tamoxifen or the analogous of tamoxifen. Finally, a level change of TRBP in the subject is discriminated to determine a tamoxifen resistance.

Abstract: The present invention provides a method of evaluating drug resistance in hormone therapy including the following steps. Firstly, a primary level of TRBP in a subject is measured, and an effective amount of tamoxifen, an active form of tamoxifen or an analogous of tamoxifen is provided to the subject. Then, a level of TRBP in the subject is measured after providing tamoxifen, the active form of tamoxifen or the analogous of tamoxifen. Finally, a level change of TRBP in the subject is discriminated to determine a tamoxifen resistance.

Abstract: A system for emulating a circuit design is presented. The system includes a host workstation coupled by an emulation interface to a field programmable gate array (FPGA) configured to emulate and verify the circuit design when the host workstation is invoked to verify the circuit design. The emulation interface is configured to provide timing and control information for at least the verify. The system further includes a non-transitory computer readable storage medium including instructions, which when executed cause a computer to compile a portion of the circuit design and an associated verification module adapted to configure the FPGA. A compilation is performed in accordance with a description file.

Abstract: An emulation system integrates multiple custom prototyping boards for emulating a circuit design. A first custom prototyping board including at least one FPGA and an interface connected to a first set of wires coupling to the at least one FPGA. A second custom prototyping board includes at least one second FPGA and an interface connected to a second set of wires coupling to the at least second FPGA. An adaptor board connects to the first custom prototyping board and the second custom prototyping board through the first interface and the second interface. The adapter board controls emulation of the circuit design and controls communication through the partitioned circuit using at least one of the first set of wires and at least one the second set of wires.

Abstract: A system for emulating a circuit design is presented. The system includes a host workstation coupled by an emulation interface to a field programmable gate array (FPGA) configured to emulate and verify the circuit design when the host workstation is invoked to verify the circuit design. The emulation interface is configured to provide timing and control information for at least the verify. The system further includes computer readable storage medium including instructions, which when executed cause a computer to compile a portion of the circuit design and an associated verification module adapted to configure the FPGA. The compilation is in accordance with a description file.

Abstract: A DC-AC frequency converter type nose cleaner includes an electromagnetic pump, a container storing a cleaning solution, a nose-washing tool and a frequency converter circuit driving the electromagnetic pump. The frequency converter circuit at least includes an oscillator circuit, a bistable circuit and a push-pull circuit. The swing speed, the swing frequency and the swing amplitude of the swing arms vary with the change of the oscillation frequency of the oscillator circuit. The DC-AC frequency converter type nose cleaner can change the pressure and the flow generated by the electromagnetic pump so as to satisfy the requirement of the discharge pressure and flow of the nose cleaner so as to overcome the defect of the discharge pressure of the conventional nose cleaner that is too big to hurt the user.

Abstract: A test system for testing prototype designs includes a host workstation, multiple interface devices, and multiple prototype boards. The prototype boards include programmable devices which implement one or more partitions of a user design and an associated verification modules. The verification modules probe signals of the partitions and transmit the probed signals to the interface devices. The verification modules can also transmit output signals generated by one or more partitions on the prototype boards to the host workstation via the interface devices, and transmit input signals, which are received from the host workstation via the interface devices, to one or more partitions on the prototype boards.

Abstract: An emulation system integrates multiple custom prototyping boards for emulating a circuit design. A first custom prototyping board including at least one FPGA and an interface connected to a first set of wires coupling to the at least one FPGA. A second custom prototyping board includes at least one second FPGA and an interface connected to a second set of wires coupling to the at least second FPGA. An adaptor board connects to the first custom prototyping board and the second custom prototyping board through the first interface and the second interface. The adapter board controls emulation of the circuit design and controls communication through the partitioned circuit using at least one of the first set of wires and at least one the second set of wires.

Abstract: A method for emulating a circuit design includes receiving, at an emulation interface, signal values associated with probed signals from a verification module of a custom prototype board which can be described by at least one board description file and can comprise at least one field programmable gate array for emulating the circuit design. The method can also include processing, the probed signal values associated with a portion of the circuit design being emulated, the emulation interface being capable of being configured to provide timing and control information to at least the verification module, and can comprise a controller and a memory device, with the controller being capable of being configured to receive the probed signal values. The method can further include storing the processed information and transmitting it to the host workstation.

Abstract: A custom prototyping board and a controller are integrated to form an emulation system for emulating a circuit design. The controller may be disposed on an adaptor board. The custom prototyping board is defined by a set of board description files which further define the FPGA device(s) used in the system as well as the wire connections among the FPGA devices and connectors on the custom prototyping board. The FPGA device(s) is configured in accordance with the partitioned circuit design. Each partitioned circuit in the FPGA device is associated with a verification module for communicating with the controller to control and probe the emulation. A host workstation may be used to link with the controller to support co-simulation or co-emulation of the circuit design.

Abstract: The present invention provides a DC-AC frequency converter type mucus suction device having an electromagnetic pump, the pressure and the flow generated in which could be changed to satisfy the requirement of the mucus suction device. The mucus suction device of the present invention comprises an electromagnetic pump, a suction device and a frequency converter circuit, wherein the frequency converter circuit at least comprises an oscillator circuit, a bistable circuit, and a push-pull circuit, wherein the electromagnetic pump is supplied with AC obtained from the oscillation of DC in the frequency converter circuit, wherein the swing speed, frequency and amplitude of the swing arms vary with the oscillation frequency of the oscillator circuit, such that the suction pressure and the suction flow of the electromagnetic pump could further be changed to obtain the most appropriate pressure and flow of the mucus suction device.

Abstract: A bubble-type nose cleaner includes a container, an electromagnetic pump, a nose-washing tool, and at least a bubble generating valve. The container has a containing space for storing a cleaning solution. The electromagnetic pump is communicated with the container through a negative pressure channel. The nose-washing tool is communicated with the electromagnetic pump through a positive pressure channel, thereby the nose-washing tool is applied with the cleaning solution drawn by the negative pressure and then discharges the cleaning solution when the electromagnetic pump actuates. The bubble generating valve is provide at a negative pressure channel or a positive pressure channel and has an air inletting opening provided at the negative pressure channel or the positive pressure channel for communicating the exterior with the interior, wherein a cap is used to control the gas-flow rate of the bubble generating valve.

Abstract: An electromagnetic pump has a frequency converter circuit for driving the electromagnetic pump, wherein the frequency converter circuit comprises an oscillator circuit, a bistable circuit and a push-pull circuit. The oscillator circuit oscillates to transform DC into a single-phase oscillating signal. The bistable circuit splits the single-phase oscillating signal into a N-phase stimulus signal and a S-phase stimulus signal. The push-pull circuit amplifies and transports the N-phase stimulus signal and the S-phase stimulus signal to the electromagnetic pump to make the swing arms of the electromagnetic pump swinging effectively, wherein the swing speed, the swing frequency and the swing amplitude of the swing arms vary with the change of the oscillation frequency of the oscillator circuit.

Abstract: A method for emulating a circuit design includes receiving, at an emulation interface, signal values associated with probed signals from a verification module of a custom prototype board which can be described by at least one board description file and can comprise at least one field programmable gate array for emulating the circuit design. The method can also include processing, the probed signal values associated with a portion of the circuit design being emulated, the emulation interface being capable of being configured to provide timing and control information to at least the verification module, and can comprise a controller and a memory device, with the controller being capable of being configured to receive the probed signal values. The method can further include storing the processed information and transmitting it to the host workstation.

Abstract: Methods and systems for testing a design under verification (DUV), the method including receiving, at an interface, configured Field Programmable Gate Array (FPGA) images and runtime control information, wherein each of the FPGA images contains a respective portion of the DUV, and a respective verification module associated with a respective FPGA device. The method further includes, sending, by the interface, each of the FPGA images to each of the respective FPGA devices associated with each of the respective FPGA images. The method also includes, sending, by the interface, timing and control information to each of the respective verification modules based on runtime control information received from the host workstation. In response to receiving timing and control information, each of the respective verification modules, controls each of the respective portions of the DUV in each of the respective FPGA devices.

Abstract: An electromagnetic pump has a frequency converter circuit for driving the electromagnetic pump, wherein the frequency converter circuit comprises an oscillator circuit, a bistable circuit and a push-pull circuit. The oscillator circuit oscillates to transform DC into a single-phase oscillating signal. The bistable circuit splits the single-phase oscillating signal into a N-phase stimulus signal and a S-phase stimulus signal. The push-pull circuit amplifies and transports the N-phase stimulus signal and the S-phase stimulus signal to the electromagnetic pump to make the swing arms of the electromagnetic pump swinging effectively, wherein the swing speed, the swing frequency and the swing amplitude of the swing arms vary with the change of the oscillation frequency of the oscillator circuit.

Abstract: A DC-AC frequency converter type nose cleaner includes an electromagnetic pump, a container storing a cleaning solution, a nose-washing tool and a frequency converter circuit driving the electromagnetic pump. The frequency converter circuit at least includes an oscillator circuit, a bistable circuit and a push-pull circuit. The electromagnetic pump is supplied with AC obtained from the oscillation of DC in the frequency converter circuit. The swing speed, the swing frequency and the swing amplitude of the swing arms vary with the change of the oscillation frequency of the oscillator circuit. Thereby, the discharge pressure and the discharge flow of the electromagnetic pump could further be changed to obtain the most appropriate discharge pressure and discharge flow of the nose cleaner.