Patents by Inventor Mingyao Ying

Mingyao Ying has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for highly efficient conversion of human stem cells to lineage-specific neurons
    Patent number: 11104881
    Abstract: The present invention relates to the field of stem cells. More specifically, the present invention provides methods and compositions useful for the highly efficient conversion of human stem cells to lineage-specific neurons. In a specific embodiment, a method of inducing differentiation of human stem cells into dopaminergic (DA) neurons comprises the steps of (a) transfecting human stem cells with a lentiviral vector encoding Atoh1, wherein the vector is Dox inducible; and (b) growing the transfected cells in culture in the presence of Dox, Sonic Hedgehog (SHH) and FGF-8b until DA neurons are induced.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: August 31, 2021
    Assignee: The Johns Hopkins University
    Inventors: Mingyao Ying, John Laterra
  • METHOD FOR HIGHLY EFFICIENT CONVERSION OF HUMAN STEM CELLS TO LINEAGE-SPECIFIC NEURONS
    Publication number: 20180305663
    Abstract: The present invention relates to the field of stem cells. More specifically, the present invention provides methods and compositions useful for the highly efficient conversion of human stem cells to lineage-specific neurons. In a specific embodiment, a method of inducing differentiation of human stem cells into dopaminergic (DA) neurons comprises the steps of (a) transfecting human stem cells with a lentiviral vector encoding Atoh1, wherein the vector is Dox inducible; and (b) growing the transfected cells in culture in the presence of Dox, Sonic Hedgehog (SHH) and FGF-8b until DA neurons are induced.
    Type: Application
    Filed: April 17, 2018
    Publication date: October 25, 2018
    Inventors: Mingyao Ying, John Laterra
  • METHOD FOR HIGHLY EFFICIENT CONVERSION OF HUMAN STEM CELLS TO LINEAGE-SPECIFIC NEURONS
    Publication number: 20160298080
    Abstract: The present invention relates to the field of stem cells. More specifically, the present invention provides methods and compositions useful for the highly efficient conversion of human stem cells to lineage-specific neurons. In a specific embodiment, a method of inducing differentiation of human stem cells into dopaminergic (DA) neurons comprises the steps of (a) transfecting human stem cells with a lentiviral vector encoding Atoh1, wherein the vector is Dox inducible; and (b) growing the transfected cells in culture in the presence of Dox, Sonic Hedgehog (SHH) and FGF-8b until DA neurons are induced.
    Type: Application
    Filed: December 3, 2014
    Publication date: October 13, 2016
    Inventors: Mingyao Ying, John Laterra