Abstract: An endoscope with an insertion tube having a proximal passive flexible section and a distal bending section. Cuts are provided in the proximal passive flexible section. Adjacent cuts are unequally spaced in the proximal passive flexible section. The proximal passive flexible section has secondary cuts adjacent to main cuts, wherein the secondary cuts are arranged closer in the longitudinal direction of the proximal passive flexible section to the adjacent main cuts on one side of the secondary cuts than to the adjacent main cuts on the other side of the secondary cuts. The main cuts extend along the circumference of the proximal passive flexible section in an interrupted manner. The proximal passive flexible section includes the main cuts, wherein at least within a subzone in the proximal passive flexible section, the main cuts are unequally spaced from each other in the longitudinal direction of the proximal passive flexible section.

Abstract: An endoscope head and endoscope including such endoscope head includes a camera, a housing element made from transparent material which surrounds the camera at least laterally and at least in portions and extends to the distal end of the endoscope head, and including at least one illumination unit which is arranged laterally from the camera and/or proximally from the camera.

Abstract: An endoscope having a proximal handle and a flexible insertion cord extending in distal direction from the handle, and further provided with an insertion cord stiffener. The stiffener includes a coil and a wire extending through the coil and being attached to the coil at the coil distal end. A control at the handle operates the stiffener by tensioning the wire.

Abstract: The invention relates to an endoscope head comprising an endoscope head body in which at least one working channel is formed, wherein a pivot member actuatable from the proximal side is provided on the distal side of the endoscope head body, wherein an Albarran lever capable of being pivoted is provided at the distal end portion of the working channel.

Abstract: The invention relates to a method for manufacturing an insertion tube of an endoscope from a tubular element, wherein the insertion tube includes a proximal passive flexible portion and a distal deflecting portion, wherein, in the proximal passive flexible portion, cuts are provided to enable the proximal passive flexible portion to be bent. In the method, the cuts are configured in the proximal passive flexible portion such that adjacent cuts do not have the same distance. The invention further relates to an endoscope including such insertion tube.

Abstract: The present disclosure provides antibodies and antigen-binding fragments that target transferrin receptor. Also provided is the use of these antibodies and antigen-binding fragments as carriers to deliver therapeutic molecules across the blood-brain barrier.

Abstract: An endoscope including an endoscope head having a housing, an examination supporting member on the distal end of the housing, and a working channel extending in the endoscope head, the working channel being formed in a hose-like or tubular working channel member and in the housing which is provided distally from the working channel member, wherein the housing has a working channel member receiving surface that faces the working channel member. On the proximal side of the working channel member receiving surface of the housing, the examination supporting member faces, in the radial direction of the working channel, a peripheral portion of the working channel member via a free space.

Abstract: An endoscope includes a circuit board on which a light source is arranged, a light guide extending in the endoscope, which receives the light from the light source and guides it to an illumination device of the endoscope, and a holder having a light guide hole for inserting the light guide, wherein the cross-section of the light guide corresponds to the cross-section of the light source for optimizing the light transmission.

Abstract: The invention relates to an endoscope control device including a control body holder, a joystick-like control element for effecting a deflection movement, and at least one control wire guided through the control body holder and transmitting the deflection movement of the control element to an element to be controlled in the endoscope. The control element extends from the control body holder in a proximal direction. The at least one control wire is fixed to the control element in a manner spaced from the control body holder. The control element includes an elastic rod element which is bendable upon actuation of the control element so as to effect a deflection movement.

Abstract: The invention relates to a method for manufacturing an endoscope insertion tube (2). The insertion tube (2) has a proximal passive flexible section (20) and a distal angled section (A). The passive flexible section (20) and the angled section (A) are integrally formed. Individual cuts (201, 202) are made in the flexible section (20), provided as a tube-like element, in such a way that adjacent individual cuts (201, 202) are equidistant from one another.

Abstract: An endoscope includes a flexible insertion tube and a bending portion controllable from a proximal side and being distally connected to the insertion tube. The bending portion includes a sleeve in which at least one pull rope runs for a pivoting movement of the bending portion, wherein the at least one pull rope is anchored to the distal end of the bending portion. A separating element dividing the cross-section of the sleeve into at least two separate chambers is arranged in the longitudinal direction of the sleeve. In one of the at least two chambers separated by the separating element, a pull rope of the at least one pull rope is arranged in the longitudinal direction of the sleeve for pivoting movement of the bending portion.

Abstract: The present invention relates to an endoscope (1) comprising a flexible insertion tube (2) and a bending portion (3) controllable from a proximal side and being distally connected to the insertion tube (2), wherein in the bending portion (3) a pull rope (11) runs for a pivoting movement of the bending portion (3), the pull rope (11) being anchored to the distal end of the bending portion (3), and wherein a biased elastic element (30) is arranged in the longitudinal direction of the bending portion (3) in parallel to the pull rope (11).

Abstract: In one embodiment, a data reconciliation engine works with data store nodes included in a distributed data store system to ensure consistency between the data store nodes. In operation, the data reconciliation receives a different data snapshot from each of the data store nodes. In response, the data reconciliation engine generates one or more recommendations designed to resolve inconsistencies between the data snapshots. The data reconciliation engine then transmits each recommendation to a different data store node. Because the data reconciliation engine performs many of the resource-intensive operations included in the data reconciliation process, the resources of the data store nodes may focus primarily on processing client requests instead of performing data reconciliation operations.

Abstract: The present invention discloses a system and method for improvement in process of measurement of body circumference using Augmented Reality (AR) and 4-point mathematical calculations approach and mobile device camera. The method includes the steps of receiving two or more individual parameters from an individual device; receiving at least one set of 4 points capture through AR technology; measurement through AR technology from the individual device, at least one dimension including user's inputs on height, weight, age, and size range; performing body segmentation on at least one dimensions to identify one or more body features associated with the human from the background; performing the distance calculation between four points; compare the calculation results with standard sizing database and displaying the final output to the individual.

Abstract: An endoscope including a handle having a handle housing and a manually operable element; and an insertion cord having a distal tip unit including an elevator element movable between a first elevator position and a second elevator position. The manually operable element is connected to the elevator element via elevator mechanics and a wire, and a manual operation of the manually operable element is transmitted via the elevator mechanics and the wire to the elevator element such that a first operation position of the manually operable element corresponds to the first elevator position and a second operation position of the manually operable element corresponds to the second elevator position. The elevator mechanics include an operation wheel connected to the manually operable element and including an operation wheel gear portion in meshing engagement with a wire wheel gear portion of a wire wheel connected to the wire.

Abstract: The invention relates to a method for manufacturing an endoscope insertion tube (2).The insertion tube (2) has a proximal passive flexible section (20) and a distal angled section (A). The entire insertion tube, including the passive flexible section (20) and the angled section (A), is formed from a single tube element. The invention further relates to an endoscope having such an insertion tube (2).

Abstract: The invention relates to a control element for an endoscopic device (A) with a retainer; at least one control wire, which can be moved back and forth in the longitudinal direction of the wire, for control purposes on the endoscopic device (A); a control wire tensioning element guided in the retainer, wherein the control wire is mounted in the control wire tensioning element; and a displacement force application device supported on the retainer, by means of the displacement force application device the control wire tensioning element can be moved relative to the retainer, in order to effect fine adjustment of the control wire.

Abstract: In one embodiment, the present specification discloses a modified spike (S) protein comprising of SEQ ID NO: 2, the modified spike protein encoded by a gene sequence of SEQ ID NO: 1, and methods of using the modified spike protein as disclosed herein.

Abstract: The invention relates to an endoscope having an endoscope head with a working channel for guiding microtools, and an Albarran lever that is insertable on and detachable from the endoscope head, and having a tool guide surface with which a tool that is guidable through the working channel may come into contact in order to be deflected in the lateral direction of the endoscope head. An Albarran lever arrangement space is delimited by two flank sections of the endoscope head that extend in the distal direction. An Albarran lever pivot shaft, from which a shaft section protrudes with respect to the Albarran lever arrangement space with a length, is supported in one of the flank sections. The Albarran lever has a shaft insertion hole for inserting the shaft section, and has a width in a direction that is parallel to the shaft insertion hole.

Abstract: The invention relates to an endoscope having a distal end portion, at which a light emitting means and an image pickup device are arranged, wherein, at the distal end portion, a light incidence region is defined at the outer circumference of the distal end portion. The longitudinal axis of the image pickup device is oriented towards the light incidence region at the outer circumference of the distal end portion.