Abstract: An approach to federated learning of a machine learning model may be provided. The approach may include broadcasting hyperparameters of a machine learning model to one or more client computing devices from a primary device associated with an outer loop or an inner loop. A gradient for the loss function may be calculated at the client device if previous gradients have been sufficiently large. If gradients exceeds a threshold, the client can send the mini-batch of gradients or the difference of the mini-batch of gradients back to the primary device. A search direction may be calculated based on the full gradient of the loss function for an outer loop or the mini-batch of gradient differences for an inner loop. A learning rate step may be calculated from the search direction. The hyperparameter may be updated for the inner loop based on the learning rate.

Abstract: A system and method can be provided for constructing and training a decision tree for machine learning. A training set can be received. The decision tree can be initialized by constructing a root node and a root solver can be trained with the training set. A processor can grow the decision tree by iteratively splitting nodes of the decision tree, where at a node of the decision tree, dimension reduction is performed on features of data of the training set received at the node, and the data having reduced dimension is split based on a routing function, for routing to another node of the decision tree. The dimension reduction and the split can be performed together at the node based on solving a nonlinear optimization problem.

Abstract: The present application provides bicyclic amines that are inhibitors of cyclin-dependent kinase 12 (CDK12), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

Abstract: Bias supplies and plasma processing systems are disclosed. One bias supply comprises an output node, a return node, and a switch network and at least one power supply coupled to the output node and the return node. The switch network and the at least one power supply configured, in combination, to apply an asymmetric periodic voltage waveform and provide a corresponding current waveform at the output node relative to the return node. A metrology component is configured to receive and sample voltage and current signals indicative of a full cycle of the periodic voltage waveform and the corresponding current waveform to provide digital representations of a full cycle of the asymmetric periodic voltage waveform and a full cycle of the corresponding current waveform.

Abstract: A medical stent may include a tubular support structure including a plurality of struts defining a plurality of cells disposed between the plurality of struts. A polymeric coating may be disposed over the tubular support structure such that a first portion of the plurality of cells are closed by the polymeric coating in a first region of the tubular support structure and a second portion of the plurality of cells in a second region of the tubular support structure remain open to fluid flow and/or tissue ingrowth therethrough. The struts in the first region of the tubular support structure and the struts in the second region of the tubular support structure may be at least partially covered by the polymeric coating.

Abstract: A contact lens for shaping a cornea of an eye of a patient to treat high cylinder astigmatism may include a peripheral portion, an alignment portion, a treatment portion, a reverse portion, and a staining feature. The peripheral portion may cause migration of epithelial cells from a periphery of a cornea of the eye of the patient towards a center of the cornea of the eye of the patient. The alignment portion may align the contact lens on the cornea. The treatment portion may cause migration of the epithelial cells from the center of the cornea towards the periphery of the cornea. The reverse portion may relieve pressure caused by the migration of the epithelial cells. The staining feature may contact the cornea, thereby reshaping the cornea to treat high cylinder astigmatism. The staining feature may apply a ribbon-shaped staining pattern to the cornea across the contact lens.

Abstract: Embodiments are provided for generating a reasonable language model learning for text data in a knowledge graph in a computing system by a processor. One or more data sources and one or more triples may be analyzed from a knowledge graph. Training data having one or more candidate labels associated with one or more of the triples may be generated. One or more reasonable language models may be trained based on the training data.

Abstract: A surface cleaning apparatus includes a recovery tank, a suction nozzle in fluid communication with the recovery tank, and a suction source in fluid communication with the suction nozzle and the recovery tank to generate a working air path to transport debris-containing fluid including air and liquid from the suction nozzle into the recovery tank. An air/liquid separator can be provided within the recovery tank for separating liquid from air in the debris-containing fluid.

Abstract: A system configured to assist blockchain-based Internet of Things (IoT) applications connect with one another and share data securely and privately is described. The system includes an IoT network configured to interact with a blockchain network. The IoT network includes IoT systems, which include IoT devices that comprise sensors. The blockchain network includes a mainchain and sidechains. Each sidechain includes a consensus protocol that run on each node and is configured to increase data and synchronization between nodes. The consensus protocol utilizes a reasoning mechanism to enable each node to deduce states of events on other nodes, a gossip algorithm to synchronize data between nodes, and a vector clock algorithm in a knowledge graph deployed on every node to allow the event created during synchronization to be linked to the previous two events.

Abstract: A computer implemented method of generating a classifier engine for machine learning includes receiving a set of data points. A semi-supervised k-means process is applied to the set of data points from each class. The set of data points in a class is clustered into multiple clusters of data points, using the semi-supervised k-means process. Multi-polytopes are constructed for one or more of the clusters from all classes. A support vector machine (SVM) process is run on every pair of clusters from all classes. Separation hyperplanes are determined for the clustered classes. Labels are determined for each cluster based on the separation by hyperplanes.

Abstract: Aspects of the disclosure relate to a dynamic event securitization and neural network analysis system. A dynamic event inspection and securitization computing platform comprising at least one processor, a communication interface, and memory storing computer-readable instructions may securitize event data prior to authorizing execution of the event. A neural network event analysis computing platform comprising at least one processor, a communication interface, and memory storing computer-readable instructions may utilize a plurality of event analysis modules, a neural network, and a decision engine to analyze the risk level values of data sharing events. The dynamic event inspection and securitization computing platform may interface with the neural network event analysis computing platform by generating data securitization flags that may be utilized by the neural network event analysis computing platform to modify event analysis results generated by the event analysis modules.

Abstract: A leather-like hybrid mycelial cellulose sheet and production thereof. Precise selection of mushroom species and reagents allows for production at low pH, thereby resulting in a strong, flexible, and dry leather-like material suitable for application in various industries.

Abstract: A surface cleaning apparatus, such as a carpet extractor, includes a base and a fluid recovery system for drawing dirty cleaning fluid from a surface to be cleaned. The fluid recovery system includes a suction nozzle in fluid communication with a recovery chamber. The suction nozzle is mounted to the base for vertical movement with respect to the base and is biased into contact with the surface to be cleaned.

Abstract: The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

Abstract: Bifurcated endoprosthetic devices, systems and methods are disclosed herein for treating disease of human vasculature. In various embodiments, a bifurcated endoprosthesis includes a trunk portion and a plurality of legs, where the legs are constrained such that they maintain alignment with one another. In some examples, the legs and bifurcation of an endoprosthetic device may be formed by cutting a tubular graft component along a portion of less than its entire circumference in a longitudinally central region, and then folding the tubular graft component along the uncut portion to define two legs, where the uncut portion defines the bifurcation. In some such examples, the folded tubular graft component can be coupled with a tubular trunk component to form the bifurcated endoprosthetic device.

Abstract: The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR3 enzyme and are useful in the treatment of FGFR3-associated diseases such as cancer.