Abstract: The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating PARP1 activity and may be used in the treatment of disorders in which PARP1 activity is implicated, such as cancer.

Abstract: The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating PARP1 activity and may be used in the treatment of disorders in which PARP1 activity is implicated, such as cancer.

Abstract: In aspects of the disclosure, a method comprises training, by a computing system, a dynamics model of a cooperative multi-agent reinforcement learning (c-MARL) environment. The method further comprises processing, by the computing system, a perturbation optimizer to generate a state perturbation of the c-MARL environment, based on the dynamics model. The method further comprises selecting one or more agents of the c-MARL system as having enhanced vulnerability. The method further comprises attacking, by the computing system, the c-MARL system based on the state perturbation and the selected one or more agents.

Abstract: The disclosure relates to anti-cancer compounds derived from a payload which binds to poly(ADP-ribose) polymerase (PARP) and a nuclear steroid-targeting epitope (B of Formula I), which components are covalently linked via a linker, to products containing the same, as well as to methods of their use and preparation.

Abstract: The present invention relates to a cardiac cell culture model system composed of a cardiac organoid and blood or blood precursor cells. The cardiac cell culture model system serves as a model for the heart, and the present invention also relates to drug screening with the cardiac cell culture model system investigating the impact of the drug on the heart.

Abstract: Methods, and systems, are presented for a Structural Bridge for Electrically Isolated Metal Clips by mounting on a substrate a first and a second circuit. These first and second circuits can include Component on Package (CoP) electronic parts that are electrically contacted to the substrate with metal clips mounted on the surface of the substrate. The metal clips are electrically connected to respective circuit first and second circuits by an electrical connection on or in the substrate. The metal clips are folded over the respective first and second circuits. The folded-over portion of the first metal clip and the folded-over portion of the second metal clip are electrically isolated from each other. A third circuit package that is mounted on and electrically connected to a folded-over portion of the first metal clip and to a folded-over portion of the second metal clip.

Abstract: A thermoplastic film which exhibits elastic-like behavior along at least one axis when stretched or elongated and then released. The thermoplastic film comprises a plurality of raised rib-like elements extending in a direction perpendicular to a main surface of the thermoplastic film. The thermoplastic film further includes a plurality of web areas positioned about the plurality of raised rib-like elements. The plurality of raised rib-like elements and plurality of web areas are arranged in a complex pattern. The complex pattern provides visual and tactile cues as the films are stretched or elongated. The complex pattern can cause the thermoplastic film to have a complex stretch profile.

Abstract: A thermoplastic film which exhibits elastic-like behavior along at least one axis when stretched or elongated and then released. The thermoplastic film comprises a plurality of raised rib-like elements extending in a direction perpendicular to a main surface of the thermoplastic film. The thermoplastic film further includes a plurality of web areas positioned about the plurality of raised rib-like elements. The plurality of raised rib-like elements and plurality of web areas are arranged in a complex pattern. The complex pattern provides visual and tactile cues as the films are stretched or elongated. The complex pattern can cause the thermoplastic film to have a complex stretch profile.

Abstract: The present invention relates to a preparation method for a self-organized cardiac organoid. The invention also relates to a cardiac tissue organoid obtained by the method and to its use in regenerative medicine, as a tissue implant, or in drug screening.

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

Abstract: A thermoplastic film which exhibits elastic-like behavior along at least one axis when stretched or elongated and then released. The thermoplastic film comprises a plurality of raised rib-like elements extending in a direction perpendicular to a main surface of the thermoplastic film. The thermoplastic film further includes a plurality of web areas positioned about the plurality of raised rib-like elements. The plurality of raised rib-like elements and plurality of web areas are arranged in a complex pattern. The complex pattern provides visual and tactile cues as the films are stretched or elongated. The complex pattern can cause the thermoplastic film to have a complex stretch profile.

Abstract: Novel bromodomain and extraterminal domain (BET) inhibitors and to therapeutic methods of treating conditions and diseases using these novel BET inhibitors are provided.

Abstract: An electronic device is disclosed. The electronic device can include a molded integrated device package, where the molded integrated device package comprising a substrate, at least one electronic element mounted to the substrate, and a molding compound in which the electronic element is at least partially embedded, a slot formed through the molding compound. The integrated package can include a conductor comprising a horizontal section and a vertical section extending nonparallel from the horizontal section, the horizontal section having a lower side attached by an adhesive to an upper portion of the molding compound and the vertical section inserted into the slot and electrically connected to the substrate or to pads on the substrate by a conductive adhesive, such as solder.

Abstract: In one embodiment, an electronic assembly can include: a first electronic device package configured to be mounted on and electrically connected with a system substrate; a second electronic device package electrically connected to the system substrate; and an electrical pathway configured to extend from the system substrate through the first electronic device package and connected to an input terminal of the second electronic device package, the electrical pathway bypassing processing circuitry of the first electronic device package.

Abstract: A thermoplastic film which exhibits elastic-like behavior along at least one axis when stretched or elongated and then released. The thermoplastic film comprises a plurality of raised rib-like elements extending in a direction perpendicular to a main surface of the thermoplastic film. The thermoplastic film further includes a plurality of web areas positioned about the plurality of raised rib-like elements. The plurality of raised rib-like elements and plurality of web areas are arranged in a complex pattern. The complex pattern provides visual and tactile cues as the films are stretched or elongated. The complex pattern can cause the thermoplastic film to have a complex stretch profile.

Abstract: In one embodiment, an electronic assembly can include: a first electronic device package configured to be mounted on and electrically connected with a system substrate; a second electronic device package electrically connected to the system substrate; and an electrical pathway configured to extend from the system substrate through the first electronic device package and connected to an input terminal of the second electronic device package, the electrical pathway bypassing processing circuitry of the first electronic device package.

Abstract: This disclosure provides compounds and compositions and methods of using those compounds and compositions to treat diseases and disorders associated with excessive transforming growth factor-beta (TGF?) activity. This disclosure also provides methods of using the compounds in combination with one or more cancer immunotherapies.

Abstract: A control circuit comprising an output controller coupled to an output side of a power converter. The output controller comprises a switch control signal generator to receive a feedback signal representative of an output of the power controller and to communicate a control signal to an input controller coupled to an input side to control a turn ON of a power switch. The control signal is generated in response to the feedback signal and is communicated in response to an enable signal. The output controller comprises an extremum locator to generate the enable signal in response to a winding signal representative of an instantaneous voltage on an output terminal of an energy transfer element and the extremum locator enables the switch control signal generator such that the transition of the power switch from the OFF state to the ON state occurs substantially when the winding signal reaches an extremum.

Abstract: A method and an electronic device are provided that include receiving at the electronic device a start and an end of an out-of-office period and an out-of-office preference for responding to new invitations to events occurring during the out-of-office period received at the electronic device, receiving at the electronic device a new invitation to an event occurring during the out-of-office period, and automatically transmitting at the electronic device a response to the new invitation based on the out-of-office preference.