Abstract: The present disclosure relates to anti-cancer uses utilizing an adenosine diphosphate (ADP)-ribose binding peptide and ADP-ribose. A pharmaceutical composition of the present disclosure accumulates ADP-ribose in cancer cells, thereby disrupting the cellular balance to induce cancer cell death, and having excellent anti-cancer effects, particularly in cancers that are resistant to conventional PRAP inhibitors.

Abstract: The present invention relates to an antibody that specifically binding to acid sphingomyelinase (ASM) and a use thereof and, more specifically to an anti-ASM monoclonal antibody which has very high binding sensitivity and specificity to ASM protein and an excellent inhibitory effect on ASM activity, and to a use thereof in treatment/diagnosis of neurodegenerative diseases.

Abstract: According to one aspect of the present invention, a body part of a CID filter of a secondary battery has a main through-hole and an auxiliary through-hole defined therein. The auxiliary hole is positioned between a CID gasket and an area of the CID filter that is electrically connected to an electrode tab.

Abstract: A display device including, a display module, the display module including, a display panel, a cover spacer disposed under the display module, and a step compensation portion disposed on the display panel and the cover spacer, and an outer structure surrounding the display module, wherein an edge portion of the display panel protrudes beyond an edge portion of the cover spacer, a recessed portion is disposed at the edge portion of the cover spacer and under the display panel, and the step compensation portion overlaps the recessed portion.

Abstract: A display device includes a cover window, a display module disposed on the cover window and including a display panel, a driving board disposed on the display module and connected to the display panel, and an outer structure at least partially surrounding the display module and the driving board on the cover window. The outer structure is in contact with the driving board.

Abstract: A display device including: a display driving module including a display panel; a cover window including a central portion overlapping the display driving module and a curved portion surrounding the display driving module; and an outer structure disposed between the display driving module and the curved portion and surrounding the display driving module, wherein the outer structure is spaced apart from the display driving module.

Abstract: A display device includes a display panel including a first non-bending area, a bending area extending from the first non-bending area, and a second non-bending area extending from the bending area, an adhesive layer disposed in the first non-bending area, a window connected to the display panel through the adhesive layer, the window including a base substrate, a light blocking pattern disposed on the base substrate, and a protrusion pattern disposed on at least a portion of the light blocking pattern, and a reinforcing layer surrounding at least a portion of the bending area.

Abstract: A secondary battery and a battery pack including the secondary battery are disclosed. According to one aspect of the present invention, the secondary battery includes: a waterproof part configured to surround at least a portion of a circumference of the electrode assembly so that a gas within the exterior passes through the waterproof part, but a liquid within the exterior does not pass through the waterproof part; and a vent part provided in an inner surface of the exterior to provide a path through which the gas within the exterior is discharged to the outside when an internal pressure of the exterior exceeds a certain value.

Abstract: A secondary battery and a battery pack including the secondary battery are disclosed. According to one aspect of the present invention, the secondary battery includes: a waterproof part configured to surround at least a portion of a circumference of the electrode assembly so that a gas within the exterior passes through the waterproof part, but a liquid within the exterior does not pass through the waterproof part; and a vent part provided in an inner surface of the exterior to provide a path through which the gas within the exterior is discharged to the outside when an internal pressure of the exterior exceeds a certain value.

Abstract: A method of manufacturing a semiconductor package of stacked semiconductor chips includes forming a reverse wire bond by bonding one end of a reverse wire to a chip pad of the second-highest semiconductor chip of the stacked semiconductor chips and connecting the other end of the reverse wire to a conductive bump on a chip pad of the uppermost semiconductor chip of the stacked semiconductor chips. The method also includes molding the stacked semiconductor chips with the reverse wire bond using a mold layer. The method further includes processing the mold layer to expose the conductive bump and the other end of the reverse wire in the reverse wire bond through an upper surface of the mold layer.

Abstract: The present disclosure relates to an adenosine diphosphate (ADP)-ribose binding peptide with anti-cancer activity, and specifically, an ADP-ribose binding peptide having a specific amino acid sequence and a modification thereof, a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient, and a pharmaceutical composition for anti-cancer adjuvant. The ADP-ribose binding peptide of the present disclosure has an excellent anti-cancer effect by accumulating ADP-ribose in cancer cells to destroy the balance, thus leading to the death of cancer cells, but not being toxic to normal cells, and when administered in combination with other anti-cancer drugs or anti-cancer radiation therapy, has a very good effect as an anti-cancer adjuvant by enhancing the reactivity to the anti-cancer drugs and radiation therapy.

Abstract: The present disclosure relates to an anti-cancer therapy using adenosine diphosphate ribose (ADP-Ribose), and specifically, to a single anti-cancer therapy of ADP-ribose and a combination therapy of ADP-ribose with an anti-cancer drug or radiation, and the like.

Abstract: Provided are nanoparticles for the selective death of cancer cells through ferroptosis and a method of preparing the same. More particularly, the nanoparticles are in a form in which a cancer cell-targeting hydrogel and iron particles are bound and aggregated, and are selectively accumulated in cancer cells, and thus exhibit an effective cancer cell killing effect through ferroptosis, and accordingly, are expected to exhibit high therapeutic effects due to less side effects.

Abstract: The present invention relates to a use of a triazole compound as a ghrelin receptor agonist and, more specifically, to a composition for preventing or treating diseases mediated by the ghrelin receptor, the composition being of a triazole compound which strongly binds to the ghrelin receptor with very high specificity. The compound provided by the present invention exhibits a strong binding force to the ghrelin receptor with very high specificity, and thus may be very usefully employed for preventing or developing a therapeutic agent for diseases mediated by the ghrelin receptor.

Abstract: The present disclosure relates to a battery pack and an operation method thereof. The battery pack includes a pack case, a plurality of cylindrical battery cells in the pack case, and a current breaking device in the pack case to connect the plurality of cylindrical battery cells and having a portion including a bimetal. The current breaking device includes a fixed end contacting an electrode terminal of the cylindrical battery cell, a free end contacting an electrode terminal of the surrounding cylindrical battery cell, and a flexible member configured to elastically press the free end toward the surrounding cylindrical battery cell. The battery pack may include a current breaking device using bimetal that is capable of quickly restoring a connection with a surrounding cylindrical battery cell when a state of a battery cell separated from the surroundings in case of an abnormal state thereof is recovered.

Abstract: The present invention relates to a novel use for HDL-ApoM-S1P (a high density lipoprotein in which apolipoprotein M is impregnated with sphingosine-1-phosphate), and more particularly, to using HDL-ApoM-S1P to prevent, improve, or treat degenerative brain disorders (in particular, Alzheimer's disease), cognitive disorders, learning disabilities, and memory disorders, and using HDL-ApoM-S1P to improve cognitive ability, learning ability, and memory. The HDL-ApoM-S1P according to the present invention not only alleviates neuroinflammation but also significantly exhibits improvement effects of cognitive disorder, learning disability, and memory disorder with respect to individuals suffering from degenerative brain disorders (in particular, Alzheimer's disease), and exhibits an effect of greatly reducing amyloid beta and tau deposition. Moreover, increased HDL-ApoM-S1P in the body also has an excellent effect of improving the cognitive, learning, and memory abilities of non-disabled individuals.

Abstract: A display device includes a substrate including a bending area, a flat area adjacent to the bending area, and first and second surfaces opposite to each other, a display unit corresponding to the flat area and on the first surface, a support layer which is on the second surface of the substrate, corresponds to the flat area, and is disconnected at the bending area to define an end portion closest to the bending area, and the substrate defining a groove in the bending area. The end portion of the support layer is bendable together with the substrate and includes a flat portion corresponding to the flat area of the substrate, and a bending portion corresponding to the bending area of the substrate. The substrate which is unbent disposes the bending portion having an acute angle of inclination with respect to the second surface of the substrate.

Abstract: A battery cell having an electrode assembly having a hollow structure with a hexagonal prism-shaped hole at a center, of which an exterior of the electrode assembly is in a shape of a hexagonal prism, and a cell case in which the electrode assembly is received, of which an exterior of the cell case is in a shape of a hexagonal prism is provided.

Abstract: According to one aspect of the present invention, a body part of a CID filter of a secondary battery has a main through-hole and an auxiliary through-hole defined therein. The auxiliary hole is positioned between a CID gasket and an area of the CID filter that is electrically connected to an electrode tab.

Abstract: The present invention relates to a method for treating degenerative neurological disorders in a subject in need thereof, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising an acid sphingomyelinase (ASM) activity inhibitor as an active ingredient.