Abstract: The present disclosure relates to a production process and device for synthesizing bisphenol A by a resin method, including a condensation reaction unit for performing a catalytic condensation reaction between phenol and acetone to generate bisphenol A, a first-stage adduct crystallization unit for mixing a concentrated solution with adduct crystals recycled after melting and then performing adduct crystallization, a liquid-phase dephenolization unit for melting an adduct to yield a bisphenol A product, a secondary adduct crystallization unit for recycling phenol and bisphenol A from a mother solution, a solvent recycling unit for recycling unreacted phenol and unreacted acetone, and discharging phenol-containing process water for sewage treatment, and a cracking and rearrangement unit for recycling the phenol from the mother solution, and convert bisphenol A, 2,4-bisphenol A and the like therein in the mother solution into the bisphenol A.

Abstract: The present application provides a method of treating castrate resistant prostate cancer in a patient, comprising administering to the patient a combination of afuresertib and CFG920, wherein the castrate resistant prostate cancer is also resistant to one or more standard of care treatments.

Abstract: A solid fabric softening composition is disclosed comprising a disintegrant system and from 5 to 65% by weight of a quaternary ammonium compound having a structure represented by formula (I): (R1)(R2)—N+—[(CH2)n—Z—R3][(CH2)m—Y—R4]A?, wherein each of R1 and R2 is independently a C1-C4 alkyl group or a C2 to C4 alkenyl group; each R3 and R4 is independently a C7 to C27 alkyl group or alkenyl group; each of Z and Y is independently —O—(O)C— or —C(O)—O—; m and n are each independently a number from 1 to 4; A? is an anionic counterion selected from methyl sulfate, ethyl sulfate, methanesulfonate, ethanesulfonate, sulfate, phosphate, nitrate, formate, carbonate, benzoate, tosylate, acetate, lactate, citrate, chloride, bromide, fluoride, iodide, and mixtures thereof, wherein the disintegrant system comprises a combination of salt and acid; and wherein the composition is in the form of a tablet.

Abstract: A solid fabric softening composition is disclosed comprising from 35 to 60% by weight of a disintegrant system and a quaternary ammonium compound having a structure represented by formula (I): (R1)(R2)N+(R3)(R4) A?, wherein each R1 and R2 is independently a C1 to C4 alkyl group or a C2 to C4 alkenyl group: each of R3 and R4 is independently a linear or branched C16 to C22 alkyl or alkenyl group: A? is an anionic counterion selected from a halide, alkyl sulfate and mixtures thereof; wherein the disintegrant system comprises a combination of salt and acid.

Abstract: Anti-ACVR2A antibodies or antigen binding fragment thereof and uses thereof for inhibiting or antagonizing ACVR2A. The antibodies and antigen binding fragments may be used in therapeutic methods for treating ACVR2A or ACVR2A ligands associated diseases or disorders, which are ameliorated or improved by inhibition of ACVR2A.

Abstract: The present disclosure relates to a thermal coupling method for preparing ethylene by ethanol dehydration and device thereof. The device includes an ethanol dehydration reaction system, a quenching compression system, an alkaline washing system, a molecular sieve drying system and an ethylene purification and propylene refrigeration cycle system; ethanol dehydration reaction products in the ethanol dehydration reaction system serve as a heat source for preheating, vaporization and superheating of a raw material of ethanol; tower bottoms of an evaporation tower in the quenching compression system serve as a heat source for preheating of a feed stream of the evaporation tower and heating of an overhead gas of a quenching tower; products of ethylene in the alkaline washing system serve as a cold source for cooling of crude ethylene.

Abstract: A binding molecule comprising a binding domain that binds to an antigen expressed on an activated hepatic stellate cells (HSC), and a functional domain that is capable of enhancing an antibody effector function such as antibody-dependent cell-mediated cytotoxicity (ADCC) toward activated HSCs. Uses of such binding molecule are also provided herein.

Abstract: The present disclosure relates to a process and a device for producing vinyl acetate by an ethylene process. By additionally arranging an ethylene recovery membrane assembly in a vinyl acetate synthesis section, the content of inert components such as nitrogen in a circulating system is controlled, ethylene gas is recovered from non-condensable gas, and a recovery rate of the ethylene reaches 58% or above. By adding sideline extraction at a refined VAC tower in a vinyl acetate refining section, a vinyl acetate product with purity higher than 99.98% is obtained, a mass fraction of acetic acid is less than or equal to 20 ppm, a mass fraction of acetaldehyde is less than or equal to 20 ppm, and a mass fraction of water is less than or equal to 100 ppm. In synthesis and refining processes of the vinyl acetate, a cooling method is adopted.

Abstract: The present disclosure relates to a process and a device for producing vinyl acetate by an ethylene process. By additionally arranging an ethylene recovery membrane assembly in a vinyl acetate synthesis section, the content of inert components such as nitrogen in a circulating system is controlled, ethylene gas is recovered from non-condensable gas, and a recovery rate of the ethylene reaches 58% or above. By adding sideline extraction at a refined VAC tower in a vinyl acetate refining section, a vinyl acetate product with purity higher than 99.98% is obtained, a mass fraction of acetic acid is less than or equal to 20 ppm, a mass fraction of acetaldehyde is less than or equal to 20 ppm, and a mass fraction of water is less than or equal to 100 ppm. In synthesis and refining processes of the vinyl acetate, a cooling method is adopted.

Abstract: The present disclosure relates to a method for producing vinyl acetate, comprising a vinyl acetate synthesis process, a vinyl acetate refining process and a separation process of vinyl acetate and ethyl acetate, including an acetic acid evaporator, an oxygen mixer, a vinyl acetate synthesis reactor, a first gas separating tower, a second gas separating tower, a recovered gas compressor, a water washing tower, an absorption tower and a desorption tower, a recycling gas compressor; the vinyl acetate refining process comprising an acetic acid tower, a crude VAC tower, and a fine VAC tower, a rectifying tower, an ethyl acetate tower, a water phase receiving tank, an extracting and rectifying tower and an ethyl acetate phase separator.

Abstract: The present disclosure relates to a thermal coupling method for preparing ethylene by ethanol dehydration and device thereof. The device includes an ethanol dehydration reaction system, a quenching compression system, an alkaline washing system, a molecular sieve drying system and an ethylene purification and propylene refrigeration cycle system; ethanol dehydration reaction products in the ethanol dehydration reaction system serve as a heat source for preheating, vaporization and superheating of a raw material of ethanol; tower bottoms of an evaporation tower in the quenching compression system serve as a heat source for preheating of a feed stream of the evaporation tower and heating of an overhead gas of a quenching tower; products of ethylene in the alkaline washing system serve as a cold source for cooling of crude ethylene.

Abstract: The present invention relates to a preparation system of ethylene by ethanol dehydration and device thereof. The device includes an ethanol dehydration reaction system, a quenching compression system, an alkaline washing system, a molecular sieve drying system, an ethylene purification system and a propylene refrigeration cycle system. Part of ethylene produced by the ethylene purification system are used as circulating ethylene in the molecular sieve drying system for desorption regeneration of molecular sieve drying towers. The molecular sieve drying system includes the steps: (1) feeding crude ethylene and water from the alkaline washing system into the molecular sieve drying system, and after removing the water therefrom, feeding the obtained crude ethylene into the ethylene purification system; and (2) feeding part of the products of ethylene, as the circulating ethylene, produced by the ethylene purification system into the molecular sieve drying system.

Abstract: The present disclosure relates to a vinyl acetate production process and device. By arranging a stabilizing process, an acetic acid recovery system and a desorption system and device, the composition of circulating gas is changed, the explosion range is narrowed, the volume fraction of maximum permissible oxygen at an inlet of a reactor is increased under the same production load and the same catalyst condition, the safety of the production process is improved, and the conversion per pass across the reaction is increased; and meanwhile, a material separation sequence is reasonably segmented according to an actual production condition. The present disclosure arranges a first gas separating tower which recovers surplus heat of reaction gas, reduces the energy consumption of the system, and therefore the energy consumption throughout the production flow process is reduced; the present disclosure further arranges the acetic acid recovery system.

Abstract: The present disclosure relates to a method for producing vinyl acetate, comprising a vinyl acetate synthesis process, a vinyl acetate refining process and a separation process of vinyl acetate and ethyl acetate, including an acetic acid evaporator, an oxygen mixer, a vinyl acetate synthesis reactor, a first gas separating tower, a second gas separating tower, a recovered gas compressor, a water washing tower, an absorption tower and a desorption tower, a recycling gas compressor; the vinyl acetate refining process comprising an acetic acid tower, a crude VAC tower, and a fine VAC tower, a rectifying tower, an ethyl acetate tower, a water phase receiving tank, an extracting and rectifying tower and an ethyl acetate phase separator.

Abstract: Disclosed is a laundry composition comprising a plurality of particles, wherein the particle comprises 30 to 95% of polyethylene glycol by weight of the particle, disintegrant, and occlusion of gas, wherein the disintegrant is effervescent disintegrant of a combination of carbonate source and acid source and wherein the particle has an average density of 1 to 1.1 g/cm3.

Abstract: The present application provides a method of treating castrate resistant prostate cancer in a patient, comprising administering to the patient a combination of afuresertib and CFG920, wherein the castrate resistant prostate cancer is also resistant to one or more standard of care treatments.

Abstract: Provided are a communication system and a communication apparatus thereof, the communication apparatus includes: a bottom case and a printed circuit board mounted on the bottom case, the communication apparatus further includes a heat-conductive mounting strip, the printed circuit board being mounted on the bottom case by means of the heat-conductive mounting strip, wherein a lower end surface of the heat-conductive mounting strip is connected to the bottom case, and an upper end surface of the heat-conductive mounting strip is connected to the printed circuit board.

Abstract: The present invention discloses a method for producing vinyl acetate. Inert gas is introduced into cycling gas to improve the explosion limit of oxygen, enlarge a stable area of a reaction system and improve the oxygen concentration of the reaction system, thus reducing the reaction temperature, prolonging the service life of a catalyst, and improving the selectivity of the vinyl acetate. The inert gas is nitrogen or a mixture of nitrogen and methane. The concentration of the inert gas at the inlet of a reactor is 8 to 30 mol %. The molar concentration of the oxygen at the inlet of the reactor is 10.5 to 12 mol %.

Abstract: The present invention provides a method, which can be operated continuously and has a wide scope of application, for destructing part of fines in slurry in a crystallizer to obtain large crystals having high purity and large crystal size, characterized in that first and second filters are installed in the crystallizer, a part of slurry containing only fines of size smaller than the fines cut size is drawn from the crystallizer, through the first filter in the crystallizer to a fines destruction loop for destructing the fines and then to the crystallizer through the second filter in the crystallizer by using a circulating pump. The two filters are switched over at regular interval and washed with each other's effluent to ensure the cintinuous operation of the above process.The present invention also provides a method for preparing crystalline bisphenol A/phenol adduct and bisphenol A with high purity and large crystal size.

Abstract: High purity and ultrapure bisphenol A is prepared in a novel process.