Abstract: The present invention discloses a catalytic hydrogenation method for carbon nine resin, comprising the following steps: 1) adding a Pt—W—Y/?-Al2O3 catalyst in the first half of a fixed bed, adding a Pd—Zr—Nd/?-Al2O3 catalyst in the second half of the fixed bed, and feeding hydrogen for reduction; and 2) catalytic hydrogenating the pretreated carbon nine resin in the fixed bed. In the present invention, different catalysts capable of reacting under the same catalytic conditions are added in the first and second halves of the fixed bed, and the two different catalysts play different roles, and can be active and complementary to each other under the same conditions. The synergistic effect of the two catalysts plays a good catalytic role. Moreover, the production process is simplified, and the production cost is saved.

Abstract: Disclosed herein relates to biopharmaceuticals, and more particularly to a continuous flow method for preparing (R)-3-hydroxy-5-hexenoate. Carbonyl reductase and isopropanol dehydrogenase are co-immobilized onto an inert solid medium simultaneously to prepare a carbonyl reductase/isopropanol dehydrogenase co-immobilized catalyst, which is then filled into a microchannel reactor of the micro reaction system. A solution containing substrate 3-carbonyl-5-hexenoate is subsequently pumped into the microchannel reactor to perform an asymmetric carbonyl reduction reaction to obtain (R)-3-hydroxy-5-hexenoate.

Abstract: Provided are the use of a mutant Ovis spp. infectious pustular dermatitis virus (ORFV) and a pharmaceutical composition thereof in the treatment of cancer.

Abstract: Therapeutic methods for administering gut microbiota and oncolytic viruses to a subject are provided. The gut microbiota serve to pre-condition, the subject's immune system to antitumor responses and augments anticancer activity of the oncolytic vims. Combinations of the gut, microbiota and viruses and uses thereof for treating and preventing cancer are provided. The present disclosure also provides methods for building elite responder selection platforms through hierarchical clustering analysis of genomic profiles for human gut microbiome.

Abstract: The present invention discloses a catalytic hydrogenation method for carbon nine resin, comprising the following steps: 1) adding a Pt—W—Y/?-Al2O3 catalyst in the first half of a fixed bed, adding a Pd—Zr—Nd/?-Al2O3 catalyst in the second half of the fixed bed, and feeding hydrogen for reduction; and 2) catalytic hydrogenating the pretreated carbon nine resin in the fixed bed. In the present invention, different catalysts capable of reacting under the same catalytic conditions are added in the first and second halves of the fixed bed, and the two different catalysts play different roles, and can be active and complementary to each other under the same conditions. The synergistic effect of the two catalysts plays a good catalytic role. Moreover, the production process is simplified, and the production cost is saved.

Abstract: Therapeutic methods for administering gut microbiota and oncolytic viruses to a subject are provided. The gut microbiota serve to pre-condition, the subject's immune system to antitumor responses and augments anticancer activity of the oncolytic vims. Combinations of the gut. microbiota and viruses and uses thereof for treating and preventing cancer are provided. The present disclosure also provides methods for building elite responder selection platforms through hierarchical clustering analysis of genomic profiles for human gut microbiome.

Abstract: Therapeutic methods for administering gut microbiota and oncolytic viruses to a subject are provided. The gut microbiota serve to pre-condition, the subject's immune system to antitumor responses and augments anticancer activity of the oncolytic vims. Combinations of the gut. microbiota and viruses and uses thereof for treating and preventing cancer are provided. The present disclosure also provides methods for building elite responder selection platforms through hierarchical clustering analysis of genomic profiles for human gut microbiome.

Abstract: Provided are an Leg1 protein, an Leg1 gene, uses and drugs thereof, which relate to the technical field of the functions and uses of genes. Very comprehensive study has been conducted on the functions of mLeg1 gene by approaches in Genetics, Molecular Biology, Biochemistry and Cell biology, with mLeg1 knockout mice as the subject. The study results show that mLeg1 protein can regulate in vivo Akt signals through EGFR, and further regulate in vivo lipogenesis. The study results provide a new means and idea for the treatment of human obesity and physical recovery of cancer patients after chemotherapy by human intervention in the expression level of hLeg1 gene and hLeg1 protein in the later period.

Abstract: Embodiments of the present invention provide a clock frequency modulation method and a clock frequency modulation apparatus. The method includes: determining N digital clocks according to a first digital clock of a system, where the N digital clocks includes a second digital clock and N-1 digital clocks except the second digital clock, and a sum of frequency ratios of the first digital clock to each of the N-1 digital clocks is equal to N-1 times a frequency ratio of the first digital clock to the second digital clock, where N is an integer greater than 2; and fitting, during a modulation period by using the N digital clocks, the first digital clock into the periodic second digital clock. The embodiments of the present invention use a clock frequency modulation technology to make energy concentrated in a frequency spread to a wider frequency range.

Abstract: Embodiments of the present invention provide an interference suppression method and apparatus, which can eliminate interference of a digital circuit with an analog circuit. The method includes: receiving a system clock, where a current frequency of the system clock is a first frequency; and converting the system clock into an optimal clock of a current sensitive frequency band, where the optimal clock and high-order harmonics of the optimal clock do not fall within a receive band of the sensitive frequency band, where the optimal clock is selected, with reference to the sensitive frequency band, from the system clock and at least one planned clock which is determined according to the first frequency, a frequency of the at least one planned clock is a second frequency, and a frequency increment of the second frequency relative to the first frequency is less than or equal to a preset threshold.

Abstract: Embodiments of the present invention provide a clock frequency modulation method and a clock frequency modulation apparatus. The method includes: determining N digital clocks according to a first digital clock of a system, where the N digital clocks includes a second digital clock and N-1 digital clocks except the second digital clock, and a sum of frequency ratios of the first digital clock to each of the N-1 digital clocks is equal to N-1 times a frequency ratio of the first digital clock to the second digital clock, where N is an integer greater than 2; and fitting, during a modulation period by using the N digital clocks, the first digital clock into the periodic second digital clock. The embodiments of the present invention use a clock frequency modulation technology to make energy concentrated in a frequency spread to a wider frequency range.

Abstract: Embodiments of the present invention provide an interference suppression method and apparatus, which can eliminate interference of a digital circuit with an analog circuit. The method includes: receiving a system clock, where a current frequency of the system clock is a first frequency; and converting the system clock into an optimal clock of a current sensitive frequency band, where the optimal clock and high-order harmonics of the optimal clock do not fall within a receive band of the sensitive frequency band, where the optimal clock is selected, with reference to the sensitive frequency band, from the system clock and at least one planned clock which is determined according to the first frequency, a frequency of the at least one planned clock is a second frequency, and a frequency increment of the second frequency relative to the first frequency is less than or equal to a preset threshold.