Patents by Inventor Minliang Zhu

Minliang Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PREPARING 5-(4-BROMOPHENYL)-4,6-DICHLOROPYRIMIDINE
    Publication number: 20200048206
    Abstract: A method for preparing 5-(4-bromophenyl)-4,6-dichloropyrimidine is provided. The method comprises the steps of: preparing methyl p-bromophenylacetate (Intermediate I) by catalytic esterification of p-bromophenylacetic acid, and then reacting with dimethyl carbonate to synthesize 2-(4-bromophenyl)-malonic acid-1,3-dimethyl ester (Intermediate 2), cyclizing with formamidine hydrochloride to obtain 5-(4-bromophenyl)-4,6-dihydroxypyrimidine (Intermediate 3), and then chlorinating to give the product 5-(4-bromophenyl)-4,6-dichloropyrimidine. In the process of preparing Intermediate 1 in the present invention, a solid acid is used as a catalyst. Moreover, in the process of preparing Intermediate 2, sodium methoxide is used as a base in place of sodium hydride or sodium amide used in the prior art. Furthermore, Intermediate 3 is prepared by a one-pot process.
    Type: Application
    Filed: January 9, 2019
    Publication date: February 13, 2020
    Applicant: ZHEJIANG XIANFENG TECHNOLOGIES CO.,LTD
    Inventors: Feifei GAO, Junlong GAO, Minliang ZHU, Wei LU, Yi LIU
  • Method for preparing 5-(4-bromophenyl)-4,6-dichloropyrimidine
    Patent number: 10556871
    Abstract: A method for preparing 5-(4-bromophenyl)-4,6-dichloropyrimidine is provided. The method comprises the steps of: preparing methyl p-bromophenylacetate (Intermediate I) by catalytic esterification of p-bromophenylacetic acid, and then reacting with dimethyl carbonate to synthesize 2-(4-bromophenyl)-malonic acid-1,3-dimethyl ester (Intermediate 2), cyclizing with formamidine hydrochloride to obtain 5-(4-bromophenyl)-4,6-dihydroxypyrimidine (Intermediate 3), and then chlorinating to give the product 5-(4-bromophenyl)-4,6-dichloropyrimidine. In the process of preparing Intermediate 1 in the present invention, a solid acid is used as a catalyst. Moreover, in the process of preparing Intermediate 2, sodium methoxide is used as a base in place of sodium hydride or sodium amide used in the prior art. Furthermore, Intermediate 3 is prepared by a one-pot process.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: February 11, 2020
    Assignee: ZHEJIANG XIANFENG TECHNOLOGIES CO., LTD.
    Inventors: Feifei Gao, Junlong Gao, Minliang Zhu, Wei Lu, Yi Liu