Patents by Inventor Minmin Yang

Minmin Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrazole-substituted arylamides as P2Xand P2Xantagonists
    Patent number: 7595405
    Abstract: Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5 and R6 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: September 29, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Michael Patrick Dillon, Ronald Charles Hawley, Li Chen, Lichun Feng, Minmin Yang
  • Triazole-substituted arylamides as P2X3 and P2X2/3 antagonists
    Publication number: 20090170874
    Abstract: Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted triazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
    Type: Application
    Filed: December 17, 2008
    Publication date: July 2, 2009
    Inventors: Li Chen, Michael Patrick Dillon, Lichun Feng, Ronald Charles Hawley, Minmin Yang
  • Pyrazole-substituted arylamides as P2X3 and P2X2/3 antagonists
    Publication number: 20090170873
    Abstract: Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted pyrazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
    Type: Application
    Filed: December 17, 2008
    Publication date: July 2, 2009
    Inventors: Li Chen, Michael Patrick Dillon, Lichun Feng, Ronald Charles Hawley, Minmin Yang
  • Imidazole-substituted arylamides as P2X3 and P2X2/3 antagonists
    Publication number: 20090163499
    Abstract: Compounds of the formula I: wherein R1 is optionally substituted imidazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.
    Type: Application
    Filed: December 17, 2008
    Publication date: June 25, 2009
    Inventors: Li Chen, Michael Patrick Dillon, Lichun Feng, Ronald Charles Hawley, Minmin Yang
  • CARBOXYL- OR HYDROXYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES
    Publication number: 20090163552
    Abstract: This invention relates to novel carboxyl- or hydroxyl-substituted benzimidazole derivatives of formula (I) wherein R1 to R6 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to FXR and can be used as medicaments.
    Type: Application
    Filed: December 10, 2008
    Publication date: June 25, 2009
    Inventors: Gregory Martin Benson, Konrad Bleicher, Uwe Grether, Bernd Kuhn, Rainer E. Martin, Jean-Marc Plancher, Hans Richter, Sven Taylor, Minmin Yang
  • Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists
    Publication number: 20090163502
    Abstract: Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5, R6 R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
    Type: Application
    Filed: December 17, 2008
    Publication date: June 25, 2009
    Inventors: Li Chen, Michael Patrick Dillon, Lichun Feng, Ronald Charles Hawley, Minmin Yang
  • METHYL-BENZIMIDAZOLE DERIVATIVES
    Publication number: 20090131482
    Abstract: The invention is concerned with novel substituted benzimidazole derivatives of formula (I) wherein R1 to R10 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds can be used as medicaments.
    Type: Application
    Filed: November 5, 2008
    Publication date: May 21, 2009
    Inventors: Gregory Martin Benson, Konrad Bleicher, Uwe Grether, Rainer E. Martin, Jean-Marc Plancher, Hans Richter, Sven Taylor, Minmin Yang
  • SUBSTITUTED BENZIMIDAZOLE DERIVATIVES
    Publication number: 20090062356
    Abstract: The invention is concerned with novel substituted benzimidazole derivatives of formula (I) wherein R1 to R10 and X are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to FXR and can be used as medicaments.
    Type: Application
    Filed: August 22, 2008
    Publication date: March 5, 2009
    Inventors: Gregory Martin Benson, Konrad Bleicher, Uwe Grether, Rainer E. Martin, Jean-Marc Plancher, Hans Richter, Sven Taylor, Minmin Yang
  • Non-nucleoside reverse transcriptase inhibitors
    Publication number: 20080146595
    Abstract: The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein R1, R2, R3, R4, R5a, R5b, R6a, R6b and X are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.
    Type: Application
    Filed: December 13, 2007
    Publication date: June 19, 2008
    Inventors: Denis John Kestesz, Christine E. Brotherton-Pleiss, Minmin Yang
  • Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists
    Publication number: 20080132494
    Abstract: Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is a group of formula A or formula B, and X, R2, R3, R4, R5, R6, Ra and Rb are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.
    Type: Application
    Filed: November 8, 2007
    Publication date: June 5, 2008
    Inventors: Michael Patrick Dillon, Ronald Charles Hawley, Li Chen, Lichun Feng, Minmin Yang
  • Novel benzimidazole derivatives
    Publication number: 20080021027
    Abstract: The invention is concerned with novel benzimidazole derivatives of formula (I) wherein R1 to R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to Farnesoid-X-receptors (FXR) and can be used to treat diseases which are modulated by FXR agonists such as diabetes and dyslipidemia.
    Type: Application
    Filed: June 22, 2007
    Publication date: January 24, 2008
    Inventors: Gregory Benson, Konrad Bleicher, Alexander Chucholowski, Henrietta Dehmlow, Uwe Grether, Bernd Kuhn, Rainer Martin, Eric Niesor, Narendra Panday, Hans Richter, Franz Schuler, Xavier Warot, Matthew Wright, Minmin Yang
  • Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists
    Publication number: 20080004442
    Abstract: Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5 and R6 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
    Type: Application
    Filed: June 28, 2007
    Publication date: January 3, 2008
    Inventors: Michael Dillon, Ronald Hawley, Li Chen, Lichun Feng, Minmin Yang