Abstract: An external preparing for skin comprising one or more than two types of 2-hydroxy benzoic acid derivative and/or salt thereof represented by the following formula: ##STR1## wherein R is an alkoxy group or alkyl group in the formula. The external preparation for the skin according to the present invention has a suppression effect on melanine generation by inhibition of tyrosinase activity. Accordingly, an excellent bleaching effect based upon the suppression of chromatosis and a high degree of safety can be obtained.

Abstract: A wire harness grommet has a funnel-like shape having a wire-passing tubular portion of a small diameter, and a partition wall-mounting portion extending from the tubular portion. The bonding between a filler layer, which is provided in a hollow portion of the funnel-shaped portion, and an inner wall surface is enhanced to thereby prevent the separation of the filler layer. Removal of the grommet from a mold can be effected satisfactorily. The inner wall surface is in the form of tiling in which flat plateaus are densely arranged and spaced from one another by joint grooves, so that the inner wall surface serves as a separation prevention surface.

Abstract: The present invention provides an isolated nucleic acid molecule encoding both a soluble and membrane-bound human .beta.-1,6-N-acetylglucosaminyltransferase, the I-branching enzyme (IGnT). The invention also provides vectors containing the isolated nucleic acid molecule encoding human IGnT as well as recombinant host cells transformed with the vectors. The invention further provides a method of preparing a membrane-bound form of human IGnT and methods of preparing and purifying soluble human IGnT and active fragments of either form. Also provided are antisense oligonucleotides complementary to a nucleic acid molecule encoding a human IGnT or an active fragment thereof, antibodies directed to the human IGnT, pharmaceutical compositions related to the human IGnT and transgenic nonhuman mammals expressing DNA encoding normal or mutant human IGnT. Also provided are methods for regulating the expression of human IGnT and methods for modifying a biological function mediated by the regulatory activity of human IGnT.

Abstract: The present invention provides a novel .beta.1.fwdarw.6 N-acetylglucosaminyltransferase, which forms core 2 oligosaccharide structures in O-glycans, and a novel acceptor molecule, leukosialin, CD43, for core 2 .beta.1.fwdarw.6 N-acetylglucosaminyltransferase activity. The amino acid sequences and nucleic acid sequences encoding these molecules, as well as active fragments thereof, also are disclosed. A method for isolating nucleic acid sequences encoding proteins having enzymatic activity is disclosed, using CHO cells that support replication of plasmid vectors having a polyoma virus origin of replication. A method to obtain a suitable cell line that expresses an acceptor molecule also is disclosed.

Abstract: A method is provided for detecting T-cell dysfunctions. The method includes detecting an alteration in the level of a protein regulating synthesis of the hexasaccharide NeuNAc.alpha.2.fwdarw.3Gal.beta.1.fwdarw.3(NeuNAc.alpha.2.fwdarw.3Gal.beta .1.fwdarw.4GlcNAc.beta.1.fwdarw.6)GalNAc on leukosialin of T-cells from a subject suspected of having a T-cell dysfunction compared to resting T-cells from a normal individual. The protein regulating synthesis of the hexasaccharide can be core 2 GlcNAc transferase and can be detected by either a change in its amount or activity. Also provided is a method of detecting T-cell dysfunctions which includes detecting an alteration in the level of leukosialin having the hexasaccharide NeuNAc.alpha.2.fwdarw.3Gal.beta.1.fwdarw.3(NeuNAc.alpha.2.fwdarw.3Gal.beta .1.fwdarw.4GlcNAc.beta.1.fwdarw.6)GlcNAc on T-cells from a subject suspected of having a T-cell dysfunction compared to resting T-cells from a normal individual. Kits for detecting T-cell dysfunction are provided as well.

Abstract: The subject invention provides a simple sensor and an easy to handle biosensor measuring apparatus for the purpose of making measurements easily, rapidly and with high accuracy for specific components within a biological specimen such as blood.The biosensor of the subject invention is provided with a protrusion or a depression in a portion of a base having at least a measurement electrode and an opposing electrode. Also, the biosensor measuring apparatus is so configurated to have a mating means in the main body of the measuring apparatus freely supporting this biosensor to contact the said sensor's protrusion or depression, and further having the activating switch of the driving power supply located in this mating means.By means of these, it is possible to prevent wasteful measuring operations, as noted in the prior art biosensors, such as inserting the sensor backwards and making measurements with the sensor inserted backwards.

Abstract: A semiconductor memory device has a device for reading stored information out of a memory element of a semiconductor by applying a reading voltage onto a word line; and a single word line clamping circuit for controlling the reading voltage applied onto the word line such that the reading voltage is close to a relatively high threshold voltage of the memory element when the reading voltage is applied onto the word line, the word line clamping circuit being commonly disposed on a plurality of word lines.

Abstract: A magnesium aluminometasilicate coated composite powder which comprises magnesium aluminometasilicate, or magnesium aluminometasilicate and at least one other powder coated on a surface of a core powder and which is usable in, for example, a skin treatment agent, decodorant, and oral composition.

Abstract: A spherical clay mineral powder or spherical composite powder comprising water-swellable clay mineral with specific surface are of 100 m.sup.2 /g or more is provided, and the composite powder can contain an organic, inorganic or metal powder, an organic substance soluble in an organic solvent or a water-soluble substance, and these spherical powders can be formulated effectively in, for example, cosmetics.

Abstract: An EPROM and a method of testing the former, in which a defective memory cell caused by defects in the insulating films between a substrate and a floating gate and between the floating gate and a control gate can be tested without writing any data in the individual memory cells by holding data lines to a low potential and word lines fed with a voltage.

Abstract: A transmission comprising a change speed mechanism and a differential housed in a transmission case. The change speed mechanism includes drive gears mounted on a transmission shaft, and driven gears meshed with drive gears. The differential includes a differential case having elongated axle-bearing bosses extending to inside walls of the transmission case. The driven gears are mounted on one of the elongated bosses to be rotatable therewith. The differential case is supported by rear wheel axles extending through the transmission case and the elongated bosses.

Abstract: An electrically programmable read only memory is equipped with latch circuits for sequentially introducing series signals which are fed through external terminals. The converter includes sequentially operated switch elements and latch circuits in order to convert the series signals into parallel signals. The thus converter parallel signals are written simultaneously in a memory array via address decoder operated selection switch elements. According to this method, the writing operations into the memory array can be conducted at a high speed even when one writing operation is relatively long as a result of the parallel signal action.

Abstract: A molded part formed by outsert-molding a resin into a through hole of a pipe part includes a pipe part and a resin part. The pipe part includes a hole having a tapered surface whose size is gradually reduced inward from an end portion of a through hole formed in an outsert-molded part such as a metal part, and a resin part has an outer shape matching the tapered surface. The resin part is formed in the pipe part by outsert molding.

Abstract: A composite powder wherein an organic or inorganic core powder is substantially completely covered with one or more types of organic, inorganic, or metallic powders having an average particle size one-fifth or less of the average particle size of the above core powder by means of mixing and compression. The composite powder may be manufactured by mixing and compressing the above core powder and coating powder using a ball mill or other mixer charged with a ball shaped mixing medium of an average diameter of 5 mm or less. This composite powder may be used in, for example, skin treatment agent, makeup type cosmetics, sunburn preventing cosmetics, deodorants.

Abstract: A propelling apparatus for a vehicle switchable between a four wheel drive mode and a two wheel drive mode. The apparatus comprises a hydraulic pump for driving hydraulic motors associated with front wheels and rear wheels, respectively. A shutoff valve is provided on oil lines extending between the hydraulic pump and one of the hydraulic motors, e.g. the motor associated with the front wheels. The shutoff valve is operable to establish the two wheel drive mode for driving only the rear wheels. A pumping preventive device prevents the hydraulic motor associated with the front wheels from effecting pumping action due to power transmitted from the front wheels when the shutoff valve is operated.

Abstract: An electromagnetic wave shielding system for an optical sensor includes: a sensor body having an aperture through which an optical signal is made incident on the sensor body; a shielding plate disposed within the sensor body, the shielding plate having an opening having a dimension of at most about one-half of the wavelength of electromagnetic waves; an optical system for gathering the optical signal which passes through the aperture of the sensor body to the dimension of the opening in the shielding plate so that it can pass through the opening; and a detecting/processing unit for detecting and processing the optical signal which passes through the opening in the shielding plate. Thus, the electromagnetic waves which have entered are prevented from passing through or are remarkably attenuated by the opening in the shielding plate, and are thereby prevented from reaching the detecting/processing unit.

Abstract: A halogen-containing resin composition comprising (A) 100 parts by weight of a halogen-containing resin, (B) 0.1 to 10 parts by weight of at least one amino acid zinc salt selected from glycine zinc salt and zinc glutamate, (C) 0.10 to 5 parts by weight of at least one carboxylic acid zinc salt selected from basic zinc salts of organic carboxylic acids, and optionally (D) 0.01 to 5 parts by weight of melamine.

Abstract: An electrically programmable read only memory is equipped with latch circuits for sequentially introducing series signals which are fed through external terminals. The converter includes sequentially operated switch elements and latch circuits in order to convert the series signals into parallel signals. The thus converted parallel signals are written simultaneously in a memory array via address decoder operated selection switch elements. According to this method, the writing operations into the memory array can be conducted at a high speed even when one writing operation is relatively long as a result of the parallel signal action.

Abstract: A substantially purified carbohydrate is provided which is isolated from chronic myelogenous leukemia cells. The carbohydrate is immunogenic and can be utilized to raise both polyclonal and monoclonal antibodies.

Abstract: An electrically programmable read only memory is equipped with latch circuits for sequentially introducing series signals which are fed through external terminals. The converter includes sequentially operated switch elements and latch circuits in order to convert the series signals into parallel signals. The thus converted parallel signals are written simultaneously in a memory array via address decoder operated selection switch elements. According to this method, the writing operations into the memory array can be conducted at a high speed even when one writing operation is relatively long as a result of this parallel signal action.