Patents by Inventor Minoru Furuya
Minoru Furuya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7919653Abstract: The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.Type: GrantFiled: July 30, 2003Date of Patent: April 5, 2011Assignees: Reverse Proteomics Research Institute Co., Ltd., Astellas Pharma Inc.Inventors: Akito Tanaka, Tomohiro Terada, Tsuruki Tamura, Takaaki Shiyama, Akira Yamazaki, Minoru Furuya, Masayuki Haramura
-
Publication number: 20080176341Abstract: The present invention provides a method of searching for a target molecule for a ligand immobilized on a metal surface or analyzing the interaction between a ligand and a target molecule, characterized in that the immobilization of the ligand on the metal surface via a hydrophilic spacers, and the method eliminates or suppresses a nonspecific interaction that prevents analysis of intermolecular interaction on a metal surface, and can intensify specific intermolecular interactions.Type: ApplicationFiled: August 19, 2004Publication date: July 24, 2008Applicant: Reverse Protemics Research Institute Co., Ltd.Inventors: Akito Tanaka, Tomohiro Terada, Tsuruki Tamura, Takaaki Shiyama, Akira Yamazaki, Minoru Furuya, Masayuki Haramura
-
Publication number: 20070093536Abstract: The present invention is intended to elucidate a molecular target of an antidiabetic such as a thiazolidine derivative. The present invention provides a screening method for an antidiabetic, comprising the steps of: bringing a candidate substance to be screened into contact with a protein represented by the following (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 2; or (b) a protein comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 with the deletion, substitution, addition, or insertion of one or plural amino acids and interacting with the antidiabetic; and detecting the interaction between the candidate substance and the protein.Type: ApplicationFiled: November 16, 2004Publication date: April 26, 2007Inventors: Yorimasa Suwa, Tsuyoshi Yamada, Hironori Osaki, Minoru Furuya
-
Publication number: 20060177943Abstract: The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.Type: ApplicationFiled: July 30, 2003Publication date: August 10, 2006Applicants: Reverse Proteomics Research Institute Co., Ltd., Fujisawa Pharmaceutical Co., Ltd.Inventors: Akito Tanaka, Tomohiro Terada, Tsuruki Tamura, Takaaki Shiyama, Akira Yamazaki, Minoru Furuya, Masayuki Haramura
-
Patent number: 6451842Abstract: A compound represented by the general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. These compounds inhibit the action of chemokines such as MIP-1&agr; and/or MCP-1 on target cells, and are useful as therapeutic and/or preventative drugs in diseases, such as atherosclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.Type: GrantFiled: May 16, 2000Date of Patent: September 17, 2002Assignees: Dupont Pharmaceuticals Company, Teijin LimitedInventors: Tatsuki Shiota, Ken-ichiro Kataoka, Minoru Imai, Takaharu Tsutsumi, Masaki Sudoh, Ryo Sogawa, Takuya Morita, Takahiko Hada, Yumiko Muroga, Osami Takenouchi, Minoru Furuya, Noriaki Endo, Christine M. Tarby, Wilna Moree, Steven Teig
-
Patent number: 6410566Abstract: A compound represented by the general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. These compounds inhibit the action of chemokines such as MIP-1&agr; and/or MCP-1 on target cells, and are useful as therapeutic and/or preventative drugs in diseases, such as atherosclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.Type: GrantFiled: July 16, 2001Date of Patent: June 25, 2002Assignees: Teijin Limited, Dupont Phamaceuticals CompanyInventors: Tatsuki Shiota, Ken-ichiro Kataoka, Minoru Imai, Takaharu Tsutsumi, Masaki Sudoh, Ryo Sogawa, Takuya Morita, Takahiko Hada, Yumiko Muroga, Osami Takenouchi, Minoru Furuya, Noriaki Endo, Christine M. Tarby, Wilna Moree, Steven Teig
-
Patent number: 6362177Abstract: A compound represented by the general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. These compounds inhibit the action of chemokines such as MIP-1&agr; and/or MCP-1 on target cells, and are useful as therapeutic and/or preventative drugs in diseases, such as atheroclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.Type: GrantFiled: July 16, 2001Date of Patent: March 26, 2002Assignees: Teijin Limited, Dupont Pharmaceuticals Research LaboratoriesInventors: Tatsuki Shiota, Ken-ichiro Kataoka, Minoru Imai, Takaharu Tsutsumi, Masaki Sudoh, Ryo Sogawa, Takuya Morita, Takahiko Hada, Yumiko Muroga, Osami Takenouchi, Minoru Furuya, Noriaki Endo, Christine M. Tarby, Wilna Moree, Steven Teig
-
Patent number: 6028208Abstract: Provided are vitamin D.sub.3 derivatives expressed by the following general formula [1] ##STR1## [wherein, R.sub.1 and R.sub.2 are each a hydrogen atom, a trialkylsilyl group, an acetyl group, a methoxymethyl group, or a tetrahydropyranyl group; R.sub.3 and R.sub.4 are each a hydrogen atom, a hydroxyl group, an acyloxy group, an alkyloxy group, an alkylthio group or an alkyl group which is optionally substituted; R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are each a hydrogen atom, a hydroxyl group, an alkyl group or an acyloxy group; R.sub.9 is a hydrogen atom, a hydroxyl group, an alkyl group or an alkylthio group; R.sub.10 is a hydrogen atom, an alkyl group or an alkyloxy group; A and B are each a hydrogen atom, a hydroxyl group, or together express a single bond; X and Y express a carbonyl oxygen, or one of them is a hydrogen atom and the other is a hydroxyl group or an acyloxy group; n is an integer of 0 to 2; m is an integer of 0 to 2], and a method for manufacturing the derivatives.Type: GrantFiled: February 22, 1999Date of Patent: February 22, 2000Assignee: Teijin LimitedInventors: Qingzhi Gao, Kenji Manabe, Minoru Furuya, Manabu Chokki, Hiroaki Mitsuhashi, Seiichi Ishizuka, Tadashi Kishimoto, Masayasu Tabe, Yasuji Sakuma, Atsuo Hazato, Hiroko Tanaka
-
Patent number: 5762954Abstract: The present invention provides an ISDN-containing patch that causes minimal occurrence of skin rash and has excellent percutaneous absorption and adhesive strength. The present invention discloses an isorbide dinitrate-containing patch comprising: an adhesive layer formed on a flexible support, wherein said layer comprises an adhesive composition containing adhesive and isosorbide dinitrate, the adhesive being composed of silicone-based adhesive (A) and polyvinyl acetate-based adhesive (B), their weight ratio being A:B=85:15 to 15:85, and the weight ratio of isosorbide dinitrate (C) to the adhesives (A+B) being (A+B):C=90:10 to 60:40.Type: GrantFiled: August 28, 1996Date of Patent: June 9, 1998Assignee: Teijin LimitedInventors: Takao Fujii, Makoto Iwata, Minoru Furuya, Michisuke Ohe
-
Patent number: 5701061Abstract: A cathode-ray tube apparatus capable of reducing a high frequency electric field radiated from the deflection yoke and the deflection and high voltage circuit to the outside of the cathode-ray tube apparatus. Mounted on the deflection yoke or on the cathode-ray tube are an induction coil for generating a pulse voltage opposite in polarity to a high pulse voltage applied to the h and an electric field cancellation electrode made of a conductive wire to which the opposite polarity pulse voltage is applied. When the opposite polarity pulse voltage is applied to the electric field cancellation electrode, the electric field cancellation electrode radiates an electric field opposite in polarity to the high frequency electric field radiated from the deflection yoke to the outside of the cathode-ray tube apparatus to reduce the intensity of the high frequency electric field.Type: GrantFiled: June 2, 1995Date of Patent: December 23, 1997Assignees: Hitachi, Ltd., Hitachi MizusawaInventors: Nobutaka Okuyama, Soichi Sakurai, Kouji Kitou, Hiroki Oguro, Isao Yoshimi, Masao Obara, Michitaka Ohsawa, Kouji Fukuma, Kazuo Majima, Yoshio Yoshiwara, Minoru Furuya
-
Patent number: 5675031Abstract: Specific optically active 4- hydroxy-2-cyclopentenone derivatives and mixtures thereof having the formula (I): ##STR1## and an anticancer-agent and a bone formation accelerator containing the same as effective active ingredients.Type: GrantFiled: March 8, 1995Date of Patent: October 7, 1997Assignee: Teijin LimitedInventors: Minoru Furuya, Satoshi Sugiura, Atsuo Hazato
-
Patent number: 5475287Abstract: A cathode-ray tube apparatus capable of reducing a high frequency electric field radiated from the deflection yoke and the deflection and high voltage circuit to the outside of the cathode-ray tube apparatus. Mounted on the deflection yoke or on the cathode-ray tube are an induction coil for generating a pulse voltage opposite in polarity to a high pulse voltage applied to the h and an electric field cancellation electrode made of a conductive wire to which the opposite polarity pulse voltage is applied. When the opposite polarity pulse voltage is applied to the electric field cancellation electrode, the electric field cancellation electrode radiates an electric field opposite in polarity to the high frequency electric field radiated from the deflection yoke to the outside of the cathode-ray tube apparatus to reduce the intensity of the high frequency electric field.Type: GrantFiled: March 5, 1993Date of Patent: December 12, 1995Assignees: Hitachi, Ltd., Hitachi Mizusawa Electronics Co., Ltd.Inventors: Nobutaka Okuyama, Soichi Sakurai, Kouji Kitou, Hiroki Oguro, Isao Yoshimi, Masao Obara, Michitaka Ohsawa, Kouji Fukuma, Kazuo Majima, Yoshio Yoshiwara, Minoru Furuya
-
Patent number: 5317239Abstract: A deflection yoke having cancelling loop coils for reducing undesired portions of a horizontal deflection magnetic field generated by a deflection yoke body without mislanding. The cancelling loop coils generate a cancelling magnetic field which includes two peaks in a front region and a rear region of the deflection yoke body in which the undesired field portions exist, respectively. The peaks are opposite in direction to the horizontal magnetic field generated by the deflection yoke body, respectively, with same ratio to the deflection magnetic field, so that the undesired magnetic field portions are under-corrected in the front portion and over-corrected in the rear portion.Type: GrantFiled: January 15, 1993Date of Patent: May 31, 1994Assignees: Hitachi, Ltd., Hitachi Mizusawa Electronics Co., Ltd.Inventors: Hiroki Ohguro, Yoshio Yoshiwara, Minoru Furuya, Nobutaka Okuyama, Soichi Sakurai, Michitaka Ohsawa