Abstract: A novel histidine derivative represented by the following formula (I), and a pharmaceutically acceptable salt and hydrate thereof, useful as a pharmaceutical agent such as analgesics for the treatment of various kinds of acute or chronic pain diseases and of neuropathic pain diseases: wherein, R1 is hydrogen, alkyl having 1 to 6 carbon(s) or benzyl which may be substituted with alkyl having 1 to 4 carbon(s) or halogen; R2 is hydrogen or alkyl having 1 to 4 carbon(s); R3 and R4 are same or different and each is hydrogen, alkyl having 1 to 4 carbon(s) or phenyl which may be substituted with any one or two of alkyl having 1 to 6 carbon(s), alkoxy having 1 to 6 carbon(s), halogen, trifluoromethyl, nitro and cyano; and R5 is hydrogen or an alkyl group having 1 to 4 carbon(s).

Abstract: The present invention is to provide a novel compound which is useful as an excellent analgesic agent. The present invention is to provide the novel histidine derivative having an excellent analgesic action and the like. The compound of the present invention is very useful as a pharmaceutical agent such as analgesics for the treatment of various kinds of acute or chronic pain diseases and of neuropathic pain diseases.

Abstract: Pharmaceutical compositions containing an isoquinoline derivative exhibit an excellent inhibitory action to an isozyme of phosphodiesterase of the type IV (PDEIV). The active component of the pharmaceutical composition is an isoquinoline derivative which is represented by the general formula: ##STR1## wherein R is an ethoxy group, or which is a pharmaceutically-acceptable salt of a compound represented by said formula. The isoquinoline derivatives have an excellent inhibitory action which is highly specific to PDEIV. They are highly useful as pharmaceuticals such as antidepressive agents, tranquilizers, antidemential agents, antiinflammatory agents, antiallergic agents, antiasthmatic agents, liver-protecting agents, and diuretic agents.

Abstract: A conductive fabric comprising conductive fibers and thermoplastic fibers with a higher heat shrinkage than that of said conductive fibers, said conductive fibers being crimped by heat shrinkage of said thermoplastic fibers. This invention also provides a conductive sheet or film comprising the conductive fabric and a base on which said conductive fabric is disposed, said conductive fabric and said base that are laminated together being fused into one piece by being heated at a temperature above the melting point of the thermoplastic fibers and melting said thermoplastic fibers.

Abstract: A remote control system for a watercraft having a remotely positioned control device and a plurality of control device for operating the engine speed, transmission control and starter. The means for transmitting the signal from the control device to the controlled devices includes a computer that is programmed for moving the throttle of the engine to neutral when a shift is being made and for limiting the speed of the engine in reverse. In addition, and emergency deceleration device is provided for rapidly closing the throttle and shifting the transmission into the opposite direction for emergency deceleration. An improved starter arrangement is incorporated wherein the transmission is moved to neutral upon initiation of a starting sequence and the started is cranked for only a predetermined time interval to prevent overheating.

Abstract: A remote control device for an outboard motor including a remotely positioned controller device that operates control devices carried by the outboard motor through optical fiber transmitted signals. The optical fibers are detachably connected to the controllers so as to permit removal of the controller. In addition, the controller is detachably supported within the associated watercraft so that it may be conveniently removed.

Abstract: Several embodiments of coupling devices for marine outboard drives for providing a coupling between an engine output shaft and the outboard drive, drive shaft. Each embodiment employs as the coupling a first portion that provides a relatively resilient driving connection for absorbing low speed torque vibrations and a second more rigid driving connection for providing a more positive power transmission at high speeds and high loads. In some embodiments, the more resilient connection is provided by a spring which may comprise either a torsional spring or a torsional coil spring. In other embodiments, elastomeric elements provide the driving connection.