Abstract: A compound represented by the formula (1) [A represents a nitrogen-containing saturated ring; m represents an integer of 0 to 2; n represents an integer of 1 to 4; G1 represents hydrogen atom, chlorine atom, hydroxyl group, an alkoxy group, or amino group; G2 represents a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, and the like; G3 represents hydrogen atom, a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, and the like; G4 represents hydroxyl group, or —N(R1)(R2) (R1 and R2 represent hydrogen atom, an alkyl group, an aralkyl group, an alkenyl group, an alkynyl group, or a saturated heterocyclic group); G5 is a substituent on a ring-constituting carbon atom of A, and represents hydrogen atom, fluorine atom, or an alkyl group] or a salt thereof, or a derivative thereof that is a prodrug, which potently inhibits Rho kinase.

Abstract: A compound represented by the formula (1) [A represents a nitrogen-containing saturated ring; m represents an integer of 0 to 2; n represents an integer of 1 to 4; G1 represents hydrogen atom, chlorine atom, hydroxyl group, an alkoxy group, or amino group; G2 represents a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, an amino group, an alkylsulfinyl group, an alkylsulfonyl group, or an aryl group; G3 represents hydrogen atom, a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, an amino group, an alkoxycarbonyl group, an acyl group, an acyloxy group, an alkylsulfinyl group, an alkylsulfonyl group, or an aryl group; Y represents a single bond, or —C(R3)(R4)— (R3 and R4 represent hydrogen atom, or an alkyl group, or alkylene groups which combine together to form a saturated hydrocarbon ring group); G4 represents hydro

Abstract: A flowmeter includes a flow sensor capable of measuring instantaneous flow rates of forward and backward flows of a fluid, smoothing means for smoothing the measured instantaneous flow rate, an integrating counter for integrating the smoothed flow rate and outputting an integrated flow rate, determination means for monitoring the smoothed flow rate to determine whether or not the fluid is fluctuating, an auxiliary counter for integrating, in place of the integrating counter, the smoothed flow rate while the fluid is judged to be fluctuating by the determination means and when fluctuation of the fluid is detected, and control means for adding an integrated flow rate held by the auxiliary counter to that held by the integrating counter when it is judged by the determination means that the fluid has begun to flow regularly, and causing the integrating counter to restart integrating the smoothed flow rate.

Abstract: A flowmeter includes a flow sensor capable of measuring instantaneous flow rates of forward and backward flows of a fluid, smoothing means for smoothing the measured instantaneous flow rate, an integrating counter for integrating the smoothed flow rate and outputting an integrated flow rate, determination means for monitoring the smoothed flow rate to determine whether or not the fluid is fluctuating, an auxiliary counter for integrating, in place of the integrating counter, the smoothed flow rate while the fluid is judged to be fluctuating by the determination means and when fluctuation of the fluid is detected, and control means for adding an integrated flow rate held by the auxiliary counter to that held by the integrating counter when it is judged by the determination means that the fluid has begun to flow regularly, and causing the integrating counter to restart integrating the smoothed flow rate.

Abstract: A compound represented by the formula (1) [A represents a nitrogen-containing saturated ring; m represents an integer of 0 to 2; n represents an integer of 1 to 4; G1 represents hydrogen atom, chlorine atom, hydroxyl group, an alkoxy group, or amino group; G2 represents a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, and the like; G3 represents hydrogen atom, a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, and the like; G4 represents hydroxyl group, or —N(R1)(R2) (R1 and R2 represent hydrogen atom, an alkyl group, an aralkyl group, an alkenyl group, an alkynyl group, or a saturated heterocyclic group); G5 is a substituent on a ring-constituting carbon atom of A, and represents hydrogen atom, fluorine atom, or an alkyl group] or a salt thereof, or a derivative thereof that is a prodrug, which potently inhibits Rho kinase.

Abstract: A compound represented by the formula (1) [A represents a nitrogen-containing saturated ring; m represents an integer of 0 to 2; n represents an integer of 1 to 4; G1 represents hydrogen atom, chlorine atom, hydroxyl group, an alkoxy group, or amino group; G2 represents a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, and the like; G3 represents hydrogen atom, a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, and the like; G4 represents hydroxyl group, or —N(R1)(R2) (R1 and R2 represent hydrogen atom, an alkyl group, an aralkyl group, an alkenyl group, an alkynyl group, or a saturated heterocyclic group); G5 is a substituent on a ring-constituting carbon atom of A, and represents hydrogen atom, fluorine atom, or an alkyl group] or a salt thereof, or a derivative thereof that is a prodrug, which potently inhibits phosphorylation of the myosin regulatory light chain.

Abstract: A compound represented by the formula (1) [A represents a nitrogen-containing saturated ring; m represents an integer of 0 to 2; n represents an integer of 1 to 4; G1 represents hydrogen atom, chlorine atom, hydroxyl group, an alkoxy group, or amino group; G2 represents a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, an amino group, an alkylsulfinyl group, an alkylsulfonyl group, or an aryl group; G3 represents hydrogen atom, a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, an amino group, an alkoxycarbonyl group, an acyl group, an acyloxy group, an alkylsulfinyl group, an alkylsulfonyl group, or an aryl group; Y represents a single bond, or —C(R3)(R4)— (R3 and R4 represent hydrogen atom, or an alkyl group, or alkylene groups which combine together to form a saturated hydrocarbon ring group); G4 represents hydro

Abstract: A vehicle includes a wheel suspension device on a right side and a wheel suspension device on a left side, with the right and left side wheel suspension devices being connected to each other through a rear frame mounted on a body frame. The right and left side wheel suspension devices include a lower arm supported at an inner end of the rear frame so as to extend outward and so as to be pivotally movable in a vertical direction. The right and left side wheel suspension devices also include an upper arm connected to the outer end of the lower arm through a wheel-supporting knuckle and so as to extend outward from the knuckle. The wheel suspension devices are provided with a rear cushion unit connected at one end to the swinging side end of one of the lower and upper arm members. At least one of the inner end of the upper arm and the other end of the rear cushion unit is supported on the rear frame so as to be pivotally movable.

Abstract: A compound represented by the formula (1) [A represents a nitrogen-containing saturated ring; m represents an integer of 0 to 2; n represents an integer of 1 to 4; G1 represents hydrogen atom, chlorine atom, hydroxyl group, an alkoxy group, or amino group; G2 represents a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, and the like; G3 represents hydrogen atom, a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, and the like; G4 represents hydroxyl group, or —N(R1)(R2) (R1 and R2 represent hydrogen atom, an alkyl group, an aralkyl group, an alkenyl group, an alkynyl group, or a saturated heterocyclic group); G5 is a substituent on a ring-constituting carbon atom of A, and represents hydrogen atom, fluorine atom, or an alkyl group] or a salt thereof, or a derivative thereof that is a prodrug, which potently inhibits phosphorylation of the myosin regulatory light chain.

Abstract: A novel compound represented by the formula (1): [R1 represents hydrogen atom, chlorine atom, or hydroxyl group; X1 . . . X2 represents—CH(R2)—CH(R3)—, —CH(R2)—CH(R3)—CH(R4)—, etc.; R2 to R4represent hydrogen atom, or an alkyl group; A1, A11, A2, and A21 represent hydrogen atom, or an alkyl group; Y represents —CH(A3)—, —CH(A3)—C(A4)(A41)—, —CH(A3)—C(A4)(A41)—C(A5)(A51)—, or a single bond; A3, A4, A41, A5, and A51 represent hydrogen atom, or an alkyl group; Z represents hydroxyl group, or —N(A6)(A61); A6 represents hydrogen atom, or an alkyl group, A61 represents hydrogen atom, an alkyl group, an aralkyl group, etc.; and groups in each of one or more combinations selected from the group consisting of combinations of A6 and A3, A6 and A4, A6 and A1, A6 and A2, A2 and A3, A2 and A4, A6 and A5, A3 and A1, and A5 and A1 may bind to each other to form a 5- or 6-membered ring], or a salt thereof, which potently inhibits the phosphorylation of myosin regulatory light chain.

Abstract: A novel compound represented by the following formula (1) or a salt thereof [wherein R1, R5, R6, R7, and R8 represent hydrogen atom, a halogen atom, hydroxyl group, an alkyl group, an alkenyl group and the like; X1 . . . X2 represents —CH(R2)—CH(R3)—, —CH(R2)—CH(R3)—CH(R4)—, —C(R2)?C(R3)—, or —C(R2)?C(R3)—CH(R4)—(R2, R3, and R4 represent hydrogen atom, or an alkyl group); A1, A11, A2, and A21 represent hydrogen atom, or an alkyl group; Y represents —CH(A3)-, —CH(A3)-C(A4)(A41)-, —CH(A3)-C(A4)(A41)-C(A5)(A51)-, or a single bond (A3, A4, A41, A5, and A51 represent hydrogen atom, or an alkyl group), and Z represents hydroxyl group, or —N(A6)(A61)(A6 represents hydrogen atom, or an alkyl group, and A61 represents hydrogen atom, an alkyl group, a substituted alkyl group and the like)], having an action of potently inhibiting phosphorylation of myosin regulatory light chain.

Abstract: A compound represented by the following formula (1) or a salt thereof: wherein R1 represents hydrogen atom, a halogen atom and the like; R2 represents hydrogen atom, a halogen atom, a C1-6 alkyl group and the like; and R3 represents —O—X—C(A1)(A11)-C(A2)(A21)-N(A31)(A3) (X represents propylene group etc., A11 and A21 represent hydrogen atom, or a C1-6 alkyl group, A31 represents a C1-6 alkyl group substituted with hydroxyl group, or hydrogen atom, and A1, A2, and A3 represent hydrogen atom, a C1-6 alkyl group and the like) and the like, which has an inhibitory activity on the phosphorylation of myosin regulatory light chain, and is useful for treatment of diseases relating to contraction of various cells and the like.

Abstract: A vehicle includes a wheel suspension device on a right side and a wheel suspension device on a left side, with the right and left side wheel suspension devices being connected to each other through a rear frame mounted on a body frame. The right and left side wheel suspension devices include a lower arm supported at an inner end of the rear frame so as to extend outward and so as to be pivotally movable in a vertical direction. The right and left side wheel suspension devices also include an upper arm connected to the outer end of the lower arm through a wheel-supporting knuckle and so as to extend outward from the knuckle. The wheel suspension devices are provided with a rear cushion unit connected at one end to the swinging side end of one of the lower and upper arm members. At least one of the inner end of the upper arm and the other end of the rear cushion unit is supported on the rear frame so as to be pivotally movable.

Abstract: A novel compound represented by the formula (1): [R1 represents hydrogen atom, chlorine atom, or hydroxyl group; X1 . . . X2 represents —CH(R2)—CH(R3)—, —CH(R2)—CH(R3)—CH(R4)—, etc.; R2to R4represent hydrogen atom, or an alkyl group; A1, A11, A2, and A21 represent hydrogen atom, or an alkyl group; Y represents —CH(A3)-, —CH(A3)-C(A4)(A41)-, —CH(A3)-C(A4)(A41)-C(A5)(A51)-, or a single bond; A3, A4, A41, A5, and A51 represent hydrogen atom, or an alkyl group; Z represents hydroxyl group, or —N(A6)(A61); A6 represents hydrogen atom, or an alkyl group, A61 represents hydrogen atom, an alkyl group, an aralkyl group, etc.; and groups in each of one or more combinations selected from the group consisting of combinations of A6 and A3, A6 and A4, A6 and A1, A6 and A2, A2 and A3, A2 and A4, A6 and A5, A3 and A1, and A5 and A1 may bind to each other to form a 5- or 6-membered ring], or a salt thereof, which potently inhibits the phosphorylation of myosin regulatory light chain.

Abstract: A compound represented by the following formula (1) or a salt thereof: wherein R1 represents hydrogen atom, a halogen atom and the like; R2 represents hydrogen atom, a halogen atom, a C1-6 alkyl group and the like; and R3 represents —O—X—C(A1)(A11)—C(A2)(A2l)—N(A3l)(A3)(X represents propylene group etc., A11 and A21 represent hydrogen atom, or a C1-6 alkyl group, A31 represents a C1-6 alkyl group substituted with hydroxyl group, or hydrogen atom, and A1, A2, and A3 represent hydrogen atom, a C1-6 alkyl group and the like) and the like, which has an inhibitory activity on the phosphorylation of myosin regulatory light chain, and is useful for treatment of diseases relating to contraction of various cells and the like.

Abstract: A method of controlling granule secretion comprising performing a treatment to increase or decrease an active form of calgranulin on a cell line having capability of secreting granules, thereby increasing or decreasing granule secretion from the cell line. A method of detecting a substance which inhibits or activates the granule secretion reaction by applying this controlling method. An active form of calgranulin is increased by making the cells permeabilized cells and adding a calgranulin and soluble calcium. Decrease of an active form of calgranulin is carried out by introducing a calgranulin antibody into cells. The method is useful for screening a substance which inhibits or activates granule secretion.

Abstract: An all terrain vehicle comprises a frame supported by at least a left wheel and a right wheel. The left wheel and the right wheel being connected to said frame by a left suspension and a right suspension respectively. The independently suspended wheels preferably are drive wheels. The wheels are driven by an engine through a transmission. The transmission is connected to the left wheel by a left half shaft and to the right wheel by a right half shaft. Constant velocity couplings are used to coupling the half shafts to the respective wheels and to the transmission. The constant velocity couplings connecting the two half shafts to the transmission are joined in a single housing. The housing includes a body portion and a gear portion. The two portions can be integrally formed. A left cage and a right cage are mounted within a left axial bore and a right axial bore formed in the body portion. The cages are secured for rotation with the body portion but can move axially within the respective bores.

Abstract: An all terrain vehicle comprises a frame supported by at least a left wheel and a right wheel. The left wheel and the right wheel being connected to said frame by a left suspension and a right suspension respectively. The independently suspended wheels preferably are drive wheels. The wheels are driven by an engine through a transmission. The transmission is connected to the left wheel by a left half shaft and to the right wheel by a right half shaft. Constant velocity couplings are used to coupling the half shafts to the respective wheels and to the transmission. The constant velocity couplings connecting the two half shafts to the transmission are joined in a single housing. The housing includes a body portion and a gear portion. The two portions can be integrally formed. A left cage and a right cage are mounted within a left axial bore and a right axial bore formed in the body portion. The cages are secured for rotation with the body portion but can move axially within the respective bores.

Abstract: A drive layout for an offroad vehicle. The vehicle has a frame, at least two wheels supporting the frame, and an internal combustion engine supported by the frame. The engine has at least one cylinder, a piston positioned in the cylinder and reciprocating along a first axis. The piston drives an output shaft of the engine which is arranged to drive at least one of the wheels through a transmission. The vehicle has a longitudinal centerline, with the output shaft of the engine extending transverse to the centerline. The transmission includes a main shaft driven by the output shaft by a belt extending along a second axis. The main shaft drives a drive shaft which extends parallel to the centerline and which is arranged to drive at least one of the wheels. The layout is arranged such that the first axis and second axis are positioned on opposite sides of the centerline.