Patents by Inventor Minoru Shindo
Minoru Shindo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4507309Abstract: A treating agent whose effective ingredient is an anthranyl derivative of the formula: ##STR1## (wherein R.sub.1 and R.sub.2 may be the same or different and represent a hydrogen atom, a hydroxyl group, a lower alkoxy group, preferably C.sub.1 -C.sub.3 alkoxy group, a lower alkyl group, preferably C.sub.1 -C.sub.3 alkyl group, a nitro group or a halogen atom) is disclosed.Type: GrantFiled: April 12, 1982Date of Patent: March 26, 1985Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Shin-ichi Kaiho, Koji Mizuno, Shun-ichi Hata, Masuo Koizumi, Masamitsu Honda, Yasushi Murakami, Shigeru Takanashi, Minoru Shindo
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Patent number: 4415573Abstract: Novel uracil derivatives of the formula ##STR1## (wherein R.sub.1, R.sub.2 R.sub.3 and X are defined in the description) and their pharmaceutically acceptable salts, process for preparing the same and pharmaceutical composition containing the same are disclosed. The uracil derivatives have good antitumor activity and, therefore, are useful as antitumor preparation.Type: GrantFiled: August 10, 1981Date of Patent: November 15, 1983Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kiyoshige Ochi, Katsuhito Miyamoto, Hiroki Mitsui, Yumiko Tsuruma, Isao Matsunaga, Takashi Matsuno, Shigeru Takanashi, Minoru Shindo
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Patent number: 4415569Abstract: Pyrazoloindazole derivatives of the formula: ##STR1## [wherein R.sub.1 is a cyano group, carboxy group, a lower alkoxycarbonyl group or a group ##STR2## (wherein R.sub.2 and R.sub.3 are each a hydrogen atom, a lower alkyl group, a phenyl group which may have a substituent or when taken together with a nitrogen atom, form a heterocyclic ring); X.sup..crclbar. is a counter ion], a process for preparing the same and a pharamaceutical composition containing the same are disclosed. The compounds of the formula above have bronchodilating action and are useful as a medicine.Type: GrantFiled: December 17, 1981Date of Patent: November 15, 1983Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Fujimura Yasuo, Tanaka Sadao, Matsunaga Isao, Yasuyuki Shiraki, Yugo Ikeda, Tamotsu Yamazaki, Yasuhiro Ohba, Kazushige Sakai, Shun-ichi Hata, Minoru Shindo
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Patent number: 4409234Abstract: Novel pyrazoloindazole derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxyl group or benzyloxyl group; R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl group or phenyl group (provided R.sub.1 and R.sub.2 are not hydrogen at the same time); and X.sup..crclbar. is a halide ion, a hydroxide ion, a methanesulfonate ion, a p-toluene sulfonate ion, a sulfate ion, a nitrate ion, a carbonate ion, an acetate ion, a benzoate ion or a salicylate ion, a process for preparing the derivatives, and a pharmaceutical composition containing the same are disclosed. The derivatives have good bronchodilating action for human without exhibiting substantially bad effects on the functioning of heart, and therefore, they are useful as a drug.Type: GrantFiled: June 3, 1982Date of Patent: October 11, 1983Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Yasuo Fujimura, Sadao Tanaka, Isao Matsunaga, Yasuyuki Shiraki, Yugo Ikeda, Tamotsu Yamazaki, Yasuhiro Ohba, Shun-ichi Hata, Minoru Shindo, Kazushige Sakai
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Patent number: 4355038Abstract: .alpha.-Substituted ureido-benzylpenicillanic acids of the formula ##STR1## (wherein R.sup.1, X and Y are as defined in the description) and pharmaceutically acceptable salts thereof, and a bactericidal composition comprising the above penicillanic acid or the salt and a pharmaceutically acceptable carrier are disclosed. The acids and salts thereof have high antibacterial activities against Gram-positive and Gram-negative bacteria, particularly those of the genus Pseudomonas.Type: GrantFiled: July 30, 1981Date of Patent: October 19, 1982Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Nobuhiro Oi, Bunya Aoki, Teizo Shinozaki, Kanji Moro, Toshio Kuroki, Isao Matsunaga, Takao Noto, Toshiyuki Nebashi, Yusuke Harada, Hisao Endo, Takao Kimura, Kana Kojima, Masahiko Matsumoto, Hiroshi Okazaki, Haruki Ogawa, Minoru Shindo
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Patent number: 4341776Abstract: Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1 R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.Type: GrantFiled: March 28, 1980Date of Patent: July 27, 1982Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Nobuhiro Oi, Bunya Aoki, Teizo Shinozaki, Kanji Moro, Isao Matsunaga, Takao Noto, Toshiyuki Nebashi, Yusuke Harada, Hisao Endo, Takao Kimura, Hiroshi Okazaki, Haruki Ogawa, Minoru Shindo
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Patent number: 4328224Abstract: Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.Type: GrantFiled: March 28, 1980Date of Patent: May 4, 1982Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Nobuhiro Oi, Bunya Aoki, Teizo Shinozaki, Kanji Moro, Isao Matsunaga, Takao Noto, Toshiyuki Nebashi, Yusuke Harada, Hisao Endo, Takao Kimura, Hiroshi Okazaki, Haruki Ogawa, Minoru Shindo
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Patent number: 4301161Abstract: Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.Type: GrantFiled: March 28, 1980Date of Patent: November 17, 1981Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Nobuhiro Oi, Bunya Aoki, Teizo Shinozaki, Kanji Moro, Isao Matsunaga, Takao Noto, Toshiyuki Nebashi, Yusuke Harada, Hisao Endo, Takao Kimura, Hiroshi Okazaki, Haruki Ogawa, Minoru Shindo
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Patent number: 4298605Abstract: Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.Type: GrantFiled: June 11, 1979Date of Patent: November 3, 1981Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Nobuhiro Oi, Bunya Aoki, Teizo Shinozaki, Kanji Moro, Isao Matsunaga, Takao Noto, Toshiyuki Nebashi, Yusuke Harada, Hisao Endo, Takao Kimura, Hiroshi Okazaki, Haruki Ogawa, Minoru Shindo
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Patent number: 4229348Abstract: Penicillanic acid derivatives which have an excellent antibacterial action particularly against bacteria belonging to family Pseudomonas aeruginosa and are represented by the formula ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 and n are as defined above, and salts thereof; and a process for preparing the same are disclosed.Type: GrantFiled: January 23, 1979Date of Patent: October 21, 1980Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Nobuhiro Oi, Bunya Aoki, Teizo Shinozaki, Kanji Moro, Isao Matsunaga, Takao Noto, Toshiyuki Nebashi, Yusuke Harada, Hisao Endo, Takao Kimura, Hiroshi Okazaki, Haruki Ogawa, Minoru Shindo
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Patent number: 4225524Abstract: Steroid derivatives represented by the formula ##STR1## wherein R.sup.1 and R.sup.2 are as defined hereunder which is useful for easily producing a wide variety of active vitamin D, and a process for preparing the same are disclosed.Type: GrantFiled: June 14, 1978Date of Patent: September 30, 1980Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kiyoshige Ochi, Isao Matsunaga, Minoru Shindo, Chikara Kaneko
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Patent number: 4221814Abstract: A terephthalic acid monoamide derivative of the formula: ##STR1## (wherein R is a straight- or branched-chain lower alkyl group; R' and R" may be the same or different, and represent a hydrogen atom, or a straight- or branched-chain lower alkyl group) or pharmaceutically acceptable salts thereof are disclosed. A process for preparing such terephthalic acid monoamide derivative or its salts, as well as an anti-allergic agent containing such derivative or its salts as an effective ingredient are also disclosed.Type: GrantFiled: June 1, 1979Date of Patent: September 9, 1980Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Sakae Takaku, Takashi Mori, Yasushi Murakami, Yoshiyuki Ohsugi, Shigeyuki Kataoka, Yasuhisa Takeda, Takashi Matsuno, Yoshimitsu Iida, Akiko Ariga, Akira Okazaki, Kazuo Igusa, Toshichika Ogasawara, Minoru Shindo
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Patent number: 4200640Abstract: A compound of the formula ##STR1## is useful for treating circulatory diseases.Type: GrantFiled: September 7, 1978Date of Patent: April 29, 1980Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroyuki Nagano, Takashi Mori, Sakae Takaku, Isao Matsunaga, Tatsuo Kujirai, Toshichika Ogasawara, Shigeru Sugano, Minoru Shindo
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Patent number: 4179452Abstract: 3.alpha.,6.alpha.-Dihydroxy-5.beta.-cholestan-24-one or its derivative represented by the formula ##STR1## wherein R is as defined hereunder which is a useful intermediate for the production of an active vitamin D, and a process for preparing the compound of the formula are disclosed.Type: GrantFiled: May 17, 1978Date of Patent: December 18, 1979Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kiyoshige Ochi, Isao Matsunaga, Minoru Shindo, Chikara Kaneko
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Patent number: 4145357Abstract: A steroid derivative represented by the formula ##STR1## wherein R is as defined hereunder and a process for preparing the same are disclosed. The derivative is an intermediate for the production of various useful compounds.Type: GrantFiled: November 28, 1977Date of Patent: March 20, 1979Assignee: Chugai Syiyaku Kabushiki KaishaInventors: Kiyoshige Ochi, Isao Matsunaga, Minoru Shindo, Chikara Kaneko
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Patent number: 4092431Abstract: A pharmaceutical composition for prevention and treatment of gastritis and peptic ulcer of mammals including human beings which contains a bis(benzamido)benzene derivative represented by the formula ##STR1## wherein X and Y are as defined hereinbelow, or an acid addition salt thereof, as an active ingredient, and a method of the use thereof are disclosed.Type: GrantFiled: April 28, 1977Date of Patent: May 30, 1978Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Takashi Mori, Sakae Takaku, Nobuhiro Oi, Minoru Shindo, Takeaki Hirano, Shigeyuki Kataoka, Kouji Furuno
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Patent number: 4092426Abstract: An aminobenzoic acid derivative represented by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are defined hereinbelow, which has excellent activity for improving liver function and for potentiating and normalizing immunity; a process for preparing the same; and a pharmaceutical composition containing the same are disclosed.Type: GrantFiled: June 1, 1976Date of Patent: May 30, 1978Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Mitsuru Tanemura, Teizo Shinozaki, Minoru Shindo, Shun-ichi Hata, Koji Mizuno, Masayoshi Ono, Kiyoshige Wakabayashi, Toshiaki Nakano, Yasuho Nishii, Takashi Matsuno, Yoshiyuki Ohsugi
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Patent number: 4058523Abstract: Bis(benzamido)-benzene derivatives having various pharmaceutical activities such as activity for preventing and treating peptic ulcer, peripheral vasodilating action, hypotensive activity and analgesic activity and represented by the formula ##STR1## wherein X, Y, Z, R.sub.1, R.sub.2 and R.sub.3 are as defined hereinafter and a process for preparing the same are disclosed.Type: GrantFiled: September 15, 1976Date of Patent: November 15, 1977Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Takashi Mori, Sakae Takaku, Nobuhiro Oi, Minoru Shindo, Takeaki Hirano, Shigeyuki Kataoka, Kouji Furuno
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Patent number: 4038416Abstract: A pharmaceutical composition for prevention and treatment of gastritis and peptic ulcer of mammals including human beings which contains a bis(benzamido)-benzene derivative represented by the formula ##STR1## wherein X and Y are as defined hereinbelow or an acid addition salt thereof as an active ingredient, and a method of the use thereof are disclosed.Type: GrantFiled: September 11, 1975Date of Patent: July 26, 1977Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Takashi Mori, Sakae Takaku, Nobuhiro Oi, Minoru Shindo, Takeaki Hirano, Shigeyuki Kataoka, Kouji Furuno
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Patent number: 4022768Abstract: 1.alpha.,25-dihydroxycholecalciferol is prepared by reacting 1,5,7-trien-3.beta.,25-diol with a 1,2,4-triazoline-dione derivative represented by the formula: ##STR1## wherein R represents an alkyl group or an aryl or substituted-aryl group; reacting the resulting 1,4-cyclic adduct represented by the general formula ##STR2## wherein R is as defined above, with a peroxide to form a 1.alpha.,2.alpha.-epoxide compound represented by the general formula ##STR3## wherein R is as defined above, reducing the so formed compound with a metal hydride to form cholesta-5,7-diene-1.alpha.,3.beta.,25-triol, irradiating the so formed compound with ultraviolet rays to form 1.alpha.,25-dihydroxyprevitamin D.sub.3, isomerizing the so formed previtamin D.sub.3, and recovering 1.alpha.,25-dihydroxycholecalciferol.Type: GrantFiled: February 12, 1976Date of Patent: May 10, 1977Assignee: Wisconsin Alumni Research FoundationInventors: Isao Matsunaga, Kiyoshige Ochi, Hiroyuki Nagano, Minoru Shindo, Masayuki Ishikawa, Chikara Kaneko, Hector F. DeLuca