Patents by Inventor Minoru Shindo

Minoru Shindo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4507309
    Abstract: A treating agent whose effective ingredient is an anthranyl derivative of the formula: ##STR1## (wherein R.sub.1 and R.sub.2 may be the same or different and represent a hydrogen atom, a hydroxyl group, a lower alkoxy group, preferably C.sub.1 -C.sub.3 alkoxy group, a lower alkyl group, preferably C.sub.1 -C.sub.3 alkyl group, a nitro group or a halogen atom) is disclosed.
    Type: Grant
    Filed: April 12, 1982
    Date of Patent: March 26, 1985
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Shin-ichi Kaiho, Koji Mizuno, Shun-ichi Hata, Masuo Koizumi, Masamitsu Honda, Yasushi Murakami, Shigeru Takanashi, Minoru Shindo
  • Patent number: 4415573
    Abstract: Novel uracil derivatives of the formula ##STR1## (wherein R.sub.1, R.sub.2 R.sub.3 and X are defined in the description) and their pharmaceutically acceptable salts, process for preparing the same and pharmaceutical composition containing the same are disclosed. The uracil derivatives have good antitumor activity and, therefore, are useful as antitumor preparation.
    Type: Grant
    Filed: August 10, 1981
    Date of Patent: November 15, 1983
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kiyoshige Ochi, Katsuhito Miyamoto, Hiroki Mitsui, Yumiko Tsuruma, Isao Matsunaga, Takashi Matsuno, Shigeru Takanashi, Minoru Shindo
  • Patent number: 4415569
    Abstract: Pyrazoloindazole derivatives of the formula: ##STR1## [wherein R.sub.1 is a cyano group, carboxy group, a lower alkoxycarbonyl group or a group ##STR2## (wherein R.sub.2 and R.sub.3 are each a hydrogen atom, a lower alkyl group, a phenyl group which may have a substituent or when taken together with a nitrogen atom, form a heterocyclic ring); X.sup..crclbar. is a counter ion], a process for preparing the same and a pharamaceutical composition containing the same are disclosed. The compounds of the formula above have bronchodilating action and are useful as a medicine.
    Type: Grant
    Filed: December 17, 1981
    Date of Patent: November 15, 1983
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Fujimura Yasuo, Tanaka Sadao, Matsunaga Isao, Yasuyuki Shiraki, Yugo Ikeda, Tamotsu Yamazaki, Yasuhiro Ohba, Kazushige Sakai, Shun-ichi Hata, Minoru Shindo
  • Patent number: 4409234
    Abstract: Novel pyrazoloindazole derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxyl group or benzyloxyl group; R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl group or phenyl group (provided R.sub.1 and R.sub.2 are not hydrogen at the same time); and X.sup..crclbar. is a halide ion, a hydroxide ion, a methanesulfonate ion, a p-toluene sulfonate ion, a sulfate ion, a nitrate ion, a carbonate ion, an acetate ion, a benzoate ion or a salicylate ion, a process for preparing the derivatives, and a pharmaceutical composition containing the same are disclosed. The derivatives have good bronchodilating action for human without exhibiting substantially bad effects on the functioning of heart, and therefore, they are useful as a drug.
    Type: Grant
    Filed: June 3, 1982
    Date of Patent: October 11, 1983
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yasuo Fujimura, Sadao Tanaka, Isao Matsunaga, Yasuyuki Shiraki, Yugo Ikeda, Tamotsu Yamazaki, Yasuhiro Ohba, Shun-ichi Hata, Minoru Shindo, Kazushige Sakai
  • Patent number: 4355038
    Abstract: .alpha.-Substituted ureido-benzylpenicillanic acids of the formula ##STR1## (wherein R.sup.1, X and Y are as defined in the description) and pharmaceutically acceptable salts thereof, and a bactericidal composition comprising the above penicillanic acid or the salt and a pharmaceutically acceptable carrier are disclosed. The acids and salts thereof have high antibacterial activities against Gram-positive and Gram-negative bacteria, particularly those of the genus Pseudomonas.
    Type: Grant
    Filed: July 30, 1981
    Date of Patent: October 19, 1982
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Nobuhiro Oi, Bunya Aoki, Teizo Shinozaki, Kanji Moro, Toshio Kuroki, Isao Matsunaga, Takao Noto, Toshiyuki Nebashi, Yusuke Harada, Hisao Endo, Takao Kimura, Kana Kojima, Masahiko Matsumoto, Hiroshi Okazaki, Haruki Ogawa, Minoru Shindo
  • Patent number: 4341776
    Abstract: Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1 R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.
    Type: Grant
    Filed: March 28, 1980
    Date of Patent: July 27, 1982
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Nobuhiro Oi, Bunya Aoki, Teizo Shinozaki, Kanji Moro, Isao Matsunaga, Takao Noto, Toshiyuki Nebashi, Yusuke Harada, Hisao Endo, Takao Kimura, Hiroshi Okazaki, Haruki Ogawa, Minoru Shindo
  • Patent number: 4328224
    Abstract: Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.
    Type: Grant
    Filed: March 28, 1980
    Date of Patent: May 4, 1982
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Nobuhiro Oi, Bunya Aoki, Teizo Shinozaki, Kanji Moro, Isao Matsunaga, Takao Noto, Toshiyuki Nebashi, Yusuke Harada, Hisao Endo, Takao Kimura, Hiroshi Okazaki, Haruki Ogawa, Minoru Shindo
  • Patent number: 4301161
    Abstract: Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.
    Type: Grant
    Filed: March 28, 1980
    Date of Patent: November 17, 1981
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Nobuhiro Oi, Bunya Aoki, Teizo Shinozaki, Kanji Moro, Isao Matsunaga, Takao Noto, Toshiyuki Nebashi, Yusuke Harada, Hisao Endo, Takao Kimura, Hiroshi Okazaki, Haruki Ogawa, Minoru Shindo
  • Patent number: 4298605
    Abstract: Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.
    Type: Grant
    Filed: June 11, 1979
    Date of Patent: November 3, 1981
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Nobuhiro Oi, Bunya Aoki, Teizo Shinozaki, Kanji Moro, Isao Matsunaga, Takao Noto, Toshiyuki Nebashi, Yusuke Harada, Hisao Endo, Takao Kimura, Hiroshi Okazaki, Haruki Ogawa, Minoru Shindo
  • Patent number: 4229348
    Abstract: Penicillanic acid derivatives which have an excellent antibacterial action particularly against bacteria belonging to family Pseudomonas aeruginosa and are represented by the formula ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 and n are as defined above, and salts thereof; and a process for preparing the same are disclosed.
    Type: Grant
    Filed: January 23, 1979
    Date of Patent: October 21, 1980
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Nobuhiro Oi, Bunya Aoki, Teizo Shinozaki, Kanji Moro, Isao Matsunaga, Takao Noto, Toshiyuki Nebashi, Yusuke Harada, Hisao Endo, Takao Kimura, Hiroshi Okazaki, Haruki Ogawa, Minoru Shindo
  • Patent number: 4225524
    Abstract: Steroid derivatives represented by the formula ##STR1## wherein R.sup.1 and R.sup.2 are as defined hereunder which is useful for easily producing a wide variety of active vitamin D, and a process for preparing the same are disclosed.
    Type: Grant
    Filed: June 14, 1978
    Date of Patent: September 30, 1980
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kiyoshige Ochi, Isao Matsunaga, Minoru Shindo, Chikara Kaneko
  • Patent number: 4221814
    Abstract: A terephthalic acid monoamide derivative of the formula: ##STR1## (wherein R is a straight- or branched-chain lower alkyl group; R' and R" may be the same or different, and represent a hydrogen atom, or a straight- or branched-chain lower alkyl group) or pharmaceutically acceptable salts thereof are disclosed. A process for preparing such terephthalic acid monoamide derivative or its salts, as well as an anti-allergic agent containing such derivative or its salts as an effective ingredient are also disclosed.
    Type: Grant
    Filed: June 1, 1979
    Date of Patent: September 9, 1980
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Sakae Takaku, Takashi Mori, Yasushi Murakami, Yoshiyuki Ohsugi, Shigeyuki Kataoka, Yasuhisa Takeda, Takashi Matsuno, Yoshimitsu Iida, Akiko Ariga, Akira Okazaki, Kazuo Igusa, Toshichika Ogasawara, Minoru Shindo
  • Patent number: 4200640
    Abstract: A compound of the formula ##STR1## is useful for treating circulatory diseases.
    Type: Grant
    Filed: September 7, 1978
    Date of Patent: April 29, 1980
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hiroyuki Nagano, Takashi Mori, Sakae Takaku, Isao Matsunaga, Tatsuo Kujirai, Toshichika Ogasawara, Shigeru Sugano, Minoru Shindo
  • Patent number: 4179452
    Abstract: 3.alpha.,6.alpha.-Dihydroxy-5.beta.-cholestan-24-one or its derivative represented by the formula ##STR1## wherein R is as defined hereunder which is a useful intermediate for the production of an active vitamin D, and a process for preparing the compound of the formula are disclosed.
    Type: Grant
    Filed: May 17, 1978
    Date of Patent: December 18, 1979
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kiyoshige Ochi, Isao Matsunaga, Minoru Shindo, Chikara Kaneko
  • Patent number: 4145357
    Abstract: A steroid derivative represented by the formula ##STR1## wherein R is as defined hereunder and a process for preparing the same are disclosed. The derivative is an intermediate for the production of various useful compounds.
    Type: Grant
    Filed: November 28, 1977
    Date of Patent: March 20, 1979
    Assignee: Chugai Syiyaku Kabushiki Kaisha
    Inventors: Kiyoshige Ochi, Isao Matsunaga, Minoru Shindo, Chikara Kaneko
  • Patent number: 4092431
    Abstract: A pharmaceutical composition for prevention and treatment of gastritis and peptic ulcer of mammals including human beings which contains a bis(benzamido)benzene derivative represented by the formula ##STR1## wherein X and Y are as defined hereinbelow, or an acid addition salt thereof, as an active ingredient, and a method of the use thereof are disclosed.
    Type: Grant
    Filed: April 28, 1977
    Date of Patent: May 30, 1978
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Takashi Mori, Sakae Takaku, Nobuhiro Oi, Minoru Shindo, Takeaki Hirano, Shigeyuki Kataoka, Kouji Furuno
  • Patent number: 4092426
    Abstract: An aminobenzoic acid derivative represented by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are defined hereinbelow, which has excellent activity for improving liver function and for potentiating and normalizing immunity; a process for preparing the same; and a pharmaceutical composition containing the same are disclosed.
    Type: Grant
    Filed: June 1, 1976
    Date of Patent: May 30, 1978
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Mitsuru Tanemura, Teizo Shinozaki, Minoru Shindo, Shun-ichi Hata, Koji Mizuno, Masayoshi Ono, Kiyoshige Wakabayashi, Toshiaki Nakano, Yasuho Nishii, Takashi Matsuno, Yoshiyuki Ohsugi
  • Patent number: 4058523
    Abstract: Bis(benzamido)-benzene derivatives having various pharmaceutical activities such as activity for preventing and treating peptic ulcer, peripheral vasodilating action, hypotensive activity and analgesic activity and represented by the formula ##STR1## wherein X, Y, Z, R.sub.1, R.sub.2 and R.sub.3 are as defined hereinafter and a process for preparing the same are disclosed.
    Type: Grant
    Filed: September 15, 1976
    Date of Patent: November 15, 1977
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Takashi Mori, Sakae Takaku, Nobuhiro Oi, Minoru Shindo, Takeaki Hirano, Shigeyuki Kataoka, Kouji Furuno
  • Patent number: 4038416
    Abstract: A pharmaceutical composition for prevention and treatment of gastritis and peptic ulcer of mammals including human beings which contains a bis(benzamido)-benzene derivative represented by the formula ##STR1## wherein X and Y are as defined hereinbelow or an acid addition salt thereof as an active ingredient, and a method of the use thereof are disclosed.
    Type: Grant
    Filed: September 11, 1975
    Date of Patent: July 26, 1977
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Takashi Mori, Sakae Takaku, Nobuhiro Oi, Minoru Shindo, Takeaki Hirano, Shigeyuki Kataoka, Kouji Furuno
  • Patent number: 4022768
    Abstract: 1.alpha.,25-dihydroxycholecalciferol is prepared by reacting 1,5,7-trien-3.beta.,25-diol with a 1,2,4-triazoline-dione derivative represented by the formula: ##STR1## wherein R represents an alkyl group or an aryl or substituted-aryl group; reacting the resulting 1,4-cyclic adduct represented by the general formula ##STR2## wherein R is as defined above, with a peroxide to form a 1.alpha.,2.alpha.-epoxide compound represented by the general formula ##STR3## wherein R is as defined above, reducing the so formed compound with a metal hydride to form cholesta-5,7-diene-1.alpha.,3.beta.,25-triol, irradiating the so formed compound with ultraviolet rays to form 1.alpha.,25-dihydroxyprevitamin D.sub.3, isomerizing the so formed previtamin D.sub.3, and recovering 1.alpha.,25-dihydroxycholecalciferol.
    Type: Grant
    Filed: February 12, 1976
    Date of Patent: May 10, 1977
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Isao Matsunaga, Kiyoshige Ochi, Hiroyuki Nagano, Minoru Shindo, Masayuki Ishikawa, Chikara Kaneko, Hector F. DeLuca