Abstract: A storage unit stores an image file that includes a plurality of dummy image data items indicating predetermined dummy images and movement specifying data specifying the movement of an image, and a plurality of display image data items indicating images of characters. A controller replaces each dummy image data item in the image file with a display image data item to generate a new image file and causes a display unit of a terminal apparatus to display the image file.

Abstract: The object aims to comprehensively analyze miRNA that undergoes epigenetic silencing in cancer to identify miRNA associated with cancer, elucidate the role of the identified miRNA in cancer, and develop a novel method for detecting cancer and a novel therapeutic agent for cancer both of which relate to the miRNA. Disclosed is a method for detecting cancer in a subject, which comprises detecting methylated CpG in a CpG island located in a promoter region of a microRNA 34b gene and/or a microRNA 34c gene in a biological sample collected from the subject. Also disclosed is a therapeutic agent for cancer, which comprises a nucleic acid encoding a BTG4 gene or BTG4, or comprises a nucleic acid encoding a miR-34b gene and/or an miR-34c gene or miR-34b and/or miR-34c.

Abstract: Provided are: a method for detecting bladder cancer with high detection sensitivity, which has a high specificity for bladder cancer and is capable of detecting bladder cancer tissues with low grade of malignancy; and a bladder cancer marker. A method for detecting bladder cancer cells, which comprises detection of the amount of expressed bladder cancer marker in a subject sample collected from a subject, said bladder cancer marker being composed of one or more miRNAs selected from among miR-124, miR-9 and miR-137; a primer which is used in the method for detecting bladder cancer cells; and a bladder cancer marker.

Abstract: The object aims to comprehensively analyze miRNA that undergoes epigenetic silencing in cancer to identify miRNA associated with cancer, elucidate the role of the identified miRNA in cancer, and develop a novel method for detecting cancer and a novel therapeutic agent for cancer both of which relate to the miRNA. Disclosed is a method for detecting cancer in a subject, which comprises detecting methylated CpG in a CpG island located in a promoter region of a microRNA 34b gene and/or a microRNA 34c gene in a biological sample collected from the subject. Also disclosed is a therapeutic agent for cancer, which comprises a nucleic acid encoding a BTG4 gene or BTG4, or comprises a nucleic acid encoding a miR-34b gene and/or an miR-34c gene or miR-34b and/or miR-34c.

Abstract: A storage unit stores an image file that includes a plurality of dummy image data items indicating predetermined dummy images and movement specifying data specifying the movement of an image, and a plurality of display image data items indicating images of characters. A controller replaces each dummy image data item in the image file with a display image data item to generate a new image file and causes a display unit of a terminal apparatus to display the image file.

Abstract: An object of the present invention is to provide a method for non-invasively diagnosing invasiveness or degree of invasion of colorectal tumors. The present invention is characterized in that it enables to obtain a specimen that can be used to detect invasive colorectal tumors by spraying a washing fluid onto the colonic mucous layer of a subject to detach the mucus from the mucous layer, and collecting the detached mucus together with the washing fluid.

Abstract: The present invention provides a method for identifying a methylated CpG containing nucleic acid by contacting a nucleic acid with a methylation sensitive restriction endonuclease that cleaves unmethylated PcG sites and contacting the sample with an isoschizomer of the methylation sensitive restriction endonuclease, which cleaves both methylated and unmethylated CpG sites. The method also includes amplification of the CpG-containing nucleic acid using CpG-specific oligonucleotide primers. A method is also provided for detecting an age associated disorder by identification of a methylated CpG containing nucleic acid. A method is further provided for evaluating the responses of a cell to an agent. A kit is useful for detection of a CpG containing nucleic acid is also provided. Nucleic acid sequences encoding novel methylated clones.

Abstract: The object aims to comprehensively analyze miRNA that undergoes epigenetic silencing in cancer to identify miRNA associated with cancer, elucidate the role of the identified miRNA in cancer, and develop a novel method for detecting cancer and a novel therapeutic agent for cancer both of which relate to the miRNA. Disclosed is a method for detecting cancer in a subject, which comprises detecting methylated CpG in a CpG island located in a promoter region of a microRNA 34b gene and/or a microRNA 34c gene in a biological sample collected from the subject. Also disclosed is a therapeutic agent for cancer, which comprises a nucleic acid encoding a BTG4 gene or BTG4, or comprises a nucleic acid encoding a miR-34b gene and/or an miR-34c gene or miR-34b and/or miR-34c.

Abstract: The present invention provides a method for identifying a methylated CpG containing nucleic acid by contacting a nucleic acid with a methylation sensitive restriction endonuclease that cleaves unmethylated PcG sites and contacting the sample with an isoschizomer of the methylation sensitive restriction endonuclease, which cleaves both methylated and unmethylated CpG sites. The method also includes amplification of the CpG-containing nucleic acid using CpG-specific oligonucleotide primers. A method is also provided for detecting an age associated disorder by identification of a methylated CpG containing nucleic acid. A method is further provided for evaluating the responses of a cell to an agent. A kit is useful for detection of a CpG containing nucleic acid is also provided. Nucleic acid sequences encoding novel methylated clones.

Abstract: There is provided a seat device for a vehicle comprising a pair of main seats disposed in the vehicle width direction including respectively a main seat cushion and main seat back, and a sub seat back disposed between the main seat backs, wherein the sub seat back is configured so as to be in an arranged position in which the sub seat back is located above the main seat cushion and before the main seat back, and the main seat backs are configured so as to be moved inward when the sub seat back is in the arranged position. Accordingly, the width of the seat can be adjusted variably, without improperly affecting spaces behind or before the seat, thereby attaining both the movement of seat and the improvement of space utility.

Abstract: The present invention provides a method for identifying a methylated CpG containing nucleic acid by contacting a nucleic acid with a methylation sensitive restriction endonuclease that cleaves unmethylated CpG sites and contacting the sample with an isoschizomer of the methylation sensitive restriction endonuclease, which cleaves both methylated and unmethylated CpG sites. The method also includes amplification of the CpG-containing nucleic acid using CpG-specific oligonucleotide primers A method is also provided for detecting an age associated disorder by identification of a methylated CpG containing nucleic acid. A method is further provided for evaluation the response of a cell to an agent A kit useful for detection of a CpG containing nucleic acid is also provided. Nucleic acid sequences encoding novel methylated clones.

Abstract: The invention relates to a sample containing a gastric mucosa lavage fluid collected from a subject who has received a gastric mucus removal treatment and a method for detecting a disease-related marker using the same. By using the sample of the invention, the disease-related marker can be detected conveniently, less invasively, highly sensitively and highly accurately.

Abstract: A armrest portion moving forward away from seat backs for allowing an object to be placed thereon is provided at the central portion of the seat backs of a rear row seat, and a movable cushion provided at a central portion of seat cushions in the vehicle width direction. The movable cushion is operative to move upward and forward away from the seat cushions to the location near a front end of the armrest portion. Accordingly, a large-scaled console can be formed at the proper level with the armrest portion and the movable cushion, thereby improving convenience.

Abstract: The seat device, disposed on the floor panel in the cabin with the instrument panel, comprises the driver seat, the assistant seat and the rear seat, wherein the assistant seat is foldable and movable forward close to the instrument panel to be located in the stored position where the length of the folded seat is made short, the rear seat is foldable and movable forward to be located in the stored position, and the assistant seat in the stored position and the rear seat in the stored position provide the substantially continuous storage space which is formed by back faces of respective seat backs and of the assistant seat and the rear seat. Thus, both the large space and the roomy cabin for passengers can be improved.

Abstract: Disclosed is a fuel tank arrangement structure for a vehicle, which is designed to position a fuel tank 30 under a floor panel 4 forming a floor of a passenger compartment of the vehicle. In the fuel tank arrangement structure, at least a laterally inward portion of the floor panel 4 is formed as a convex floor portion 7 protruding upward from a general surface 8 of the floor panel 4, and at least a laterally inward portion of the fuel tank 30 is formed as a convex fuel-tank portion 30a protruding upward. The convex fuel-tank portion 30a is positioned within a space defined by the convex floor portion 7 while positioning the remaining portion of the fuel tank 30 at a height position lower than the general surface 8 of the floor panel 4, and a seat 9 (10) is positioned inside the passenger compartment and above the convex floor portion 7.

Abstract: A seat back is configured to be folded on a seat cushion, a baggage-compartment board is provided in a baggage compartment so as to be supported to move vertically, and there is provided a linkage mechanism to operate the seat back to be folded as the baggage-compartment board moves upward. Accordingly, the seat back can be folded on the seat cushion as the baggage-compartment board moves upward and a difference in level between a back face of the folded seat back and a baggage-compartment floor can be diminished, so operability at a baggage loading can be improved.

Abstract: A armrest portion moving forward away from seat backs for allowing an object to be placed thereon is provided at the central portion of the seat backs of a rear row seat, and a movable cushion provided at a central portion of seat cushions in the vehicle width direction. The movable cushion is operative to move upward and forward away from the seat cushions to the location near a front end of the armrest portion. Accordingly, a large-scaled console can be formed at the proper level with the armrest portion and the movable cushion, thereby improving convenience.

Abstract: There is provided the seat device for a vehicle, which is disposed on the rear floor panel in the cabin equipped with the ingress and egress opening at the side, comprising the first seat being provided so as to be folded, the second seat being provided beside the first seat, and the second-seat moving mechanism (the seat slide rails) to move the second seat laterally to the space of the original existing location of the first seat before the first seat has been folded. Accordingly, there can be provided a storage space beside the seat to allow an easy loading (easy access) from the outside of the vehicle, thereby improving facilities of the vehicle.

Abstract: In a seat device for a vehicle comprising a front-row seat including a driver seat and an assistant seat and a rear-row seat provided behind the front-row seat, respective front-row and rear-row seats being provided in a cabin which includes an ingress and egress opening, at a side face, the rear-row seat is configured so as to be located in a normal use position and in a stored position where a longitudinal thickness thereof is made short, and the assistant seat is configured so as to be moved rearward from a position beside the driver seat to a position which corresponds to the normal use position of the rear-row seat. Accordingly, a space in the cabin properly can be utilized, by effectively enlarging a rearward-movement range of the front-row seat including the assistant seat with a simple structure.

Abstract: Disclosed is a fuel tank arrangement structure for a vehicle, which is designed to position a fuel tank 30 under a floor panel 4 forming a floor of a passenger compartment of the vehicle. In the fuel tank arrangement structure, at least a laterally inward portion of the floor panel 4 is formed as a convex floor portion 7 protruding upward from a general surface 8 of the floor panel 4, and at least a laterally inward portion of the fuel tank 30 is formed as a convex fuel-tank portion 30a protruding upward. The convex fuel-tank portion 30a is positioned within a space defined by the convex floor portion 7 while positioning the remaining portion of the fuel tank 30 at a height position lower than the general surface 8 of the floor panel 4, and a seat 9 (10) is positioned inside the passenger compartment and above the convex floor portion 7.