Patents by Inventor Minqing Rong
Minqing Rong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240043807Abstract: Provided herein are methods and compositions for differentiating pluripotent cells, In embodiments, pluripotent cells are differentiated to form myoblast precursor cells, In embodiments, myoblast precursor cells are differentiated to form myoblasts. In embodiments, myoblasts are cultured to form myotubes. Media for culturing cells, cell products, and uses thereof are also described herein.Type: ApplicationFiled: December 20, 2021Publication date: February 8, 2024Inventors: Lingyan ZHANG, Minqing RONG, Nianwei LIN
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Patent number: 7960128Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: GrantFiled: March 7, 2008Date of Patent: June 14, 2011Assignee: The Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez
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Patent number: 7960127Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: GrantFiled: February 25, 2008Date of Patent: June 14, 2011Assignee: The Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez
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Patent number: 7803982Abstract: The present invention relates to the discovery, identification and characterization of a receptor protein, referred to herein as T1R3, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses transgenic animals and cells that do not express functional T1R3 protein, particularly knock-out animals and cells, and transgenic animals and cells that express a non-native T1R3 protein. Experimental model systems based on these animals and cells can be used to study T1R3-mediated taste transduction and responses of the components of the T1R3 signal transduction pathway to various tastants, furthering our understanding of the molecular biology and biochemistry of taste. Such model systems would also be useful for screening for novel tastants and taste modulators, such as enhancers of desirable flavors, and blockers of undesirable flavors.Type: GrantFiled: July 15, 2004Date of Patent: September 28, 2010Assignee: The Mount Sinai School of Medicine of New York UniversityInventors: Robert Margolskee, Minqing Rong, Sami Damak
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Publication number: 20080182266Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: ApplicationFiled: March 7, 2008Publication date: July 31, 2008Applicant: Mount Sinai School of Medicine of New York UniversityInventors: Robert F. MARGOLSKEE, Liquan HUANG, Minqing RONG, Marianna MAX, Cristian A. PEREZ
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Publication number: 20080166743Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: ApplicationFiled: February 25, 2008Publication date: July 10, 2008Applicant: MOUNT SINAI SCHOOL OF MEDICINEInventors: Robert F. MARGOLSKEE, Liquan HUANG, Minqing RONG, Marianna MAX, Cristian A. PEREZ
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Patent number: 7364867Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: GrantFiled: April 13, 2001Date of Patent: April 29, 2008Assignee: The Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez
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Patent number: 7341842Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: GrantFiled: April 17, 2006Date of Patent: March 11, 2008Assignee: The Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez
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Publication number: 20060292548Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: ApplicationFiled: April 17, 2006Publication date: December 28, 2006Applicant: Mount Sinai School of MedicineInventors: Robert Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian Perez
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Publication number: 20050177886Abstract: The present invention relates to the discovery, identification and characterization of a receptor protein, referred to herein as T1R3, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses transgenic animals and cells that do not express functional T1R3 protein, particularly knock-out animals and cells, and transgenic animals and cells that express a non-native T1R3 protein. Experimental model systems based on these animals and cells can be used to study T1R3-mediated taste transduction and responses of the components of the T1R3 signal transduction pathway to various tastants, furthering our understanding of the molecular biology and biochemistry of taste. Such model systems would also be useful for screening for novel tastants and taste modulators, such as enhancers of desirable flavors, and blockers of undesirable flavors.Type: ApplicationFiled: July 15, 2004Publication date: August 11, 2005Inventors: Robert Margolskee, Minqing Rong, Sami Damak
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Publication number: 20020037515Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: ApplicationFiled: April 13, 2001Publication date: March 28, 2002Applicant: Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez