Abstract: An oral suspension comprising (a) an antibiotic composition which comprises coated micropellets and optionally one or more excipients, (b) additional excipients, and (c) a solvent, wherein said coated micropellets comprise (i) a core comprising at least one antibiotic; (ii) an inner coating comprising at least one cellulose polymer which is not an enteric coating polymer; and (iii) an outer coating comprising at least one enteric coating polymer, wherein said coated micropellets have a mean particle size of about 100 ?m to about 650 ?m. The oral suspension of the invention is characterized by a lack of bitter taste.

Abstract: The invention provides an antibiotic composition comprising coated micropellets and a method for preparing said antibiotic composition.

Abstract: A process for preparing a pharmaceutical tablet comprising: (a) mixing a valproate compound with at least one excipient to form a premix; (b) adding a sufficient amount of water to the premix of Step (a) and mixing to form a wet granulation; (c) drying the wet granulation of Step (b) at a temperature and time sufficient to form granules, wherein the granules are essentially free of an organic solvent; (d) coating the granules of Step (c) to form coated granules; and (e) compressing the coated granules of Step (d) to form a tablet. The aqueous granulation of the invention does not have the environmental and safety drawbacks of organic solvent granulations.

Abstract: A pharmaceutical composition for oral administration comprising a compression coated solid dosage form of a bitter or unpleasant tasting pharmaceutically active agent. Included are compression coated oral dosage forms of 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide or a pharmaceutically acceptable salt or solvate thereof as active ingredient. The compression coated solid dosage forms are of use in the treatment of conditions associated with cephalic pain, in particular migraine.

Abstract: An extended-release pharmaceutical composition comprising a core and a coating, wherein said core comprises propranolol or a pharmaceutically acceptable salt thereof and at least one excipient, and said coating comprises at least one water-soluble polymer and at least one water-insoluble polymer, wherein said coating is heated at a temperature of about 30° C. to about 70° C. after being applied to said core.

Abstract: A pharmaceutical composition in the form of a bilayer tablet comprising: (a) a first discrete portion made with Formulation (A) which comprises a sympathomimetic drug, or a pharmaceutically acceptable salt thereof, and a first carrier base material which provides a sustained-release of the sympathomimetic drug or the pharmaceutically acceptable salt thereof, said first carrier base material comprising a mixture of: (i) a filler; (ii) a cellulose binder selected from the group consisting of hydroxypropyl methylcellulose, hydroxypropyl cellulose, and mixtures thereof, wherein the hydroxypropyl cellulose has a molecular weight of at least 80,000; (iii) ethylcellulose; (iv) a wax; and (v) a lubricant; and (b) a second discrete portion made with Formulation (B) which comprises a piperidinoalkanol compound, or a pharmaceutically acceptable salt thereof, and a second carrier base material which provides an immediate-release of the piperidinoalkanol or the pharmaceutically acceptable salt thereof, said second carrier

Abstract: An oral suspension comprising (a) an antibiotic composition which comprises coated micropellets and optionally one or more excipients, (b) additional excipients, and (c) a solvent, wherein said coated micropellets comprise (i) a core comprising at least one antibiotic; (ii) an inner coating comprising at least one cellulose polymer which is not an enteric coating polymer; and (iii) an outer coating comprising at least one enteric coating polymer, wherein said coated micropellets have a mean particle size of about 100 ?m to about 650 ?m. The oral suspension of the invention is characterized by a lack of bitter taste.

Abstract: A taste masking composition comprising micropellets containing an antibiotic wherein said micropellets have an inner coating comprising at least one cellulose polymer which is not an enteric coating polymer and an outer coating comprising an enteric coating polymer, wherein said micropellets have a particle size of about 100 ?m to about 650 ?m. The micropellets are characterized by (i) a lack of bitter taste; (ii) fast dissolution; and (iii) increased bioavailability of antibiotic as compared to antibiotic containing pellets having a drug-polymer matrix.

Abstract: A pharmaceutical composition for oral administration comprising a compression coated solid dosage form of a bitter or unpleasant tasting pharmaceutically active agent. Included are compression coated oral dosage forms of 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide or a pharmaceutically acceptable salt or solvate thereof as active ingredient. The compression coated solid dosage forms are of use in the treatment of conditions associated with cephalic pain, in particular migraine.