Patents by Inventor Minzhang Chen

Minzhang Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes and intermediates
    Patent number: 7381827
    Abstract: The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: June 3, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Minzhang Chen, Andrew D. Jones, Philip L. Nyce, Martin Trudeau, David J. Guerin, John R. Snoonian
  • Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof
    Publication number: 20080114179
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Application
    Filed: November 6, 2007
    Publication date: May 15, 2008
    Inventors: Jeonghan Park, Anantha Sudhakar, George Wong, Minzhang Chen, Juergen Weber, Xiaojing Yang, Daw Kwok, Ingyu Jeon, Ramani Raghavan, Maria Tamarez, Weidong Tong, Eugene Vater
  • Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl
    Patent number: 7326795
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Grant
    Filed: June 15, 2004
    Date of Patent: February 5, 2008
    Assignee: Schering Corporation
    Inventors: Anantha Sudhakar, Vilas Dahanukar, Ilia A. Zavialov, Cecilia Orr, Hoa N. Nguyen, Juergen Weber, Ingyu Jeon, Minzhang Chen, Michael D. Green, George S. Wong, Jeonghan Park, Tetsuo Iwama
  • Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof
    Patent number: 7309717
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Grant
    Filed: June 15, 2004
    Date of Patent: December 18, 2007
    Assignee: Schering Corporation
    Inventors: Jeonghan Park, Anantha Sudhakar, George S. Wong, Minzhang Chen, Juergen Weber, Xiaojing Yang, Daw-Jong Kwok, Ingyu Jeon, Ramani R. Raghavan, Maria Tamarez, Weidong Tong, Eugene J. Vater
  • Processes and intermediates for preparing steric compounds
    Publication number: 20070244334
    Abstract: This invention relates to processes and intermediates for the preparation of an alpha-amino beta-hydroxy acid of Formula 1 wherein the variables R1, R?1 and R2 are defined herein and the compound of Formula 1 has an enantiomeric excess (ee) of 55% or greater.
    Type: Application
    Filed: March 14, 2007
    Publication date: October 18, 2007
    Inventors: Gerald Tanoury, Minzhang Chen, Young Jung, Raymond Forslund
  • Deuterated hepatitis C protease inhibitors
    Publication number: 20070225297
    Abstract: A deuterated ?-ketoamido steric specific compound of the formula wherein D denotes a deuterium atom on a steric specific carbon atom.
    Type: Application
    Filed: March 14, 2007
    Publication date: September 27, 2007
    Inventors: Robert Perni, Youssef Bennani, Gregor Zlokarnik, Gerald Tanoury, Minzhang Chen, Young Jung, Raymond Forslund, Francois Maltais
  • Processes and intermediates
    Publication number: 20070087973
    Abstract: The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.
    Type: Application
    Filed: August 18, 2006
    Publication date: April 19, 2007
    Inventors: Gerald Tanoury, Minzhang Chen, John Cochran
  • Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof
    Publication number: 20060030734
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Application
    Filed: September 27, 2005
    Publication date: February 9, 2006
    Inventors: Minzhang Chen, Michael Green, Fucheng Zhang
  • Synthesis of piperidine and piperazine compounds as CCR5 antagonists
    Patent number: 6992189
    Abstract: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: January 31, 2006
    Assignee: Schering Corporation
    Inventors: William Leong, Minzhang Chen, Bosco A. D'sa, Man Zhu, Tong Xiao, Xiongwei Shi, Suhan Tang, Dinesh Gala, Andrew J. Goodman, Christopher M. Nielsen, Gary M. Lee, Juan A. Gamboa, Andrew D. Jones
  • Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof
    Patent number: 6992220
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Grant
    Filed: June 15, 2004
    Date of Patent: January 31, 2006
    Assignee: Schering Corporation
    Inventors: Minzhang Chen, Michael D. Green, Fucheng Zhang
  • Processes and intermediates
    Publication number: 20060020016
    Abstract: The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
    Type: Application
    Filed: March 11, 2005
    Publication date: January 26, 2006
    Inventors: Gerald Tanoury, Minzhang Chen, Andrew Jones, Philip Nyce, Martin Trudeau, David Guerin, John Snoonian
  • Preparation of rotamer mixtures of pharmaceutical salts
    Patent number: 6936718
    Abstract: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of specific, preferred rotamer or rotameric pair of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing desired rotamers of pharmaceutically useful salts.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: August 30, 2005
    Assignee: Schering Corporation
    Inventors: Minzhang Chen, Bosco D'sa, William Leong, Suhan Tang
  • Synthesis of piperidine and piperazine compounds as CCR5 antagonists
    Publication number: 20050187248
    Abstract: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:
    Type: Application
    Filed: March 24, 2005
    Publication date: August 25, 2005
    Inventors: William Leong, Minzhang Chen, Bosco D'sa, Man Zhu, Tong Xiao, Xiongwei Shi, Suhan Tang, Dinesh Gala, Andrew Goodman, Christopher Nielsen, Gary Lee, Juan Gamboa, Andrew Jones
  • Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl
    Publication number: 20050059800
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Application
    Filed: June 15, 2004
    Publication date: March 17, 2005
    Inventors: Anantha Sudhakar, Vilas Dahanukar, Ilia Zavialov, Cecilia Orr, Hoa Nguyen, Juergen Weber, Ingyu Jeon, Minzhang Chen, Michael Green, George Wong, Jeonghan Park, Tetsuo Iwama
  • Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof
    Publication number: 20050059648
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Application
    Filed: June 15, 2004
    Publication date: March 17, 2005
    Inventors: Jeonghan Park, Anantha Sudhakar, George Wong, Minzhang Chen, Juergen Weber, Xiaojing Yang, Daw-Jong Kwok, Ingyu Jeon, Ramani Raghavan, Maria Tamarez, Weidong Tong, Eugene Vater
  • Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof
    Publication number: 20050020689
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Application
    Filed: June 15, 2004
    Publication date: January 27, 2005
    Inventors: Minzhang Chen, Michael Green, Fucheng Zhang
  • Synthesis of 4-[(Z)-4-bromophenyl)(ethoxyimino) methyl]-1'-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbony)]-4'-methyl-1,4-?bipiperidine
    Patent number: 6818773
    Abstract: In one embodiment, the present invention describes the synthesis of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1′-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbonyl]-4′-methyl-1,4′-bipiperidine, and intermediates therefor from easily available starting materials by a simple route.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: November 16, 2004
    Assignee: Schering Corporation
    Inventors: Minzhang Chen, Bosco Anthony D'Sa, William W. Leong, Tong Gan, George S. K. Wong, Suhan Tang, Christopher Michael Nielsen
  • Synthesis of piperidine and piperazine compounds as CCR5 antagonists
    Publication number: 20040024217
    Abstract: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV: 1
    Type: Application
    Filed: March 27, 2003
    Publication date: February 5, 2004
    Applicant: Schering Corporation
    Inventors: William Leong, Minzhang Chen, Bosco A. D'sa, Man Zhu, Tong Xiao, Xiongwei Shi, Suhan Tang, Dinesh Gala, Andrew J. Goodman, Christopher M. Nielsen, Gary M. Lee, Juan A. Gamboa, Andrew D. Jones
  • Preparation of pharmaceutical salts
    Publication number: 20030139446
    Abstract: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of specific, preferred rotamer or rotameric pair of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing desired rotamers of pharmaceutically useful salts.
    Type: Application
    Filed: November 26, 2002
    Publication date: July 24, 2003
    Applicant: Schering Corporation
    Inventors: Minzhang Chen, Bosco D'sa, William Leong, Suhan Tang
  • Synthesis of 4-[(Z)-4-bromophenyl)(ethoxyimino) methyl]-1'-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbonyl]-4'-methyl-1,4-'bipiperidine
    Publication number: 20030105131
    Abstract: In one embodiment, the present invention describes the synthesis of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1′-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbonyl]-4′-methyl-1,4′-bipiperidine, and intermediates therefor from easily available starting materials by a simple route.
    Type: Application
    Filed: October 11, 2002
    Publication date: June 5, 2003
    Applicant: SCHERING CORPORATION
    Inventors: Minzhang Chen, Bosco Anthony D'Sa, William W. Leong, Tong Gan, George S.K. Wong, Suhan Tang, Christopher Michael Nielsen