Publication number: 20250388543
Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
Type:
Application
Filed:
April 21, 2023
Publication date:
December 25, 2025
Applicant:
VERTEX PHARMACEUTICALS INCORPORATED
Inventors:
Mark Thomas MILLER, Dennis James HURLEY, Timothy Donald NEUBERT, Vijayalaksmi ARUMUGAM, Sara Sabina HADIDA RUAH, Jason McCARTNEY, Jinglan ZHOU, Jaclyn CHAU, Robert Martin DEMORET, Senait G. GHIRMAI, Roman Askatovich VALIULIN, Alexander Frederik KINTZER, David Robert SLOCHOWER, Kathleen AERTGEERTS, Elizabeth Mary BECK, James Jun Bon MUI, Miranda Adele WRIGHT, Ronald Marcellus Alphonsus KNEGTEL, Ewa Iwona CHUDYK, Joanne Louise PINDER, Reece JACQUES, James DODD, Iain SIMPSON
Publication number: 20240368135
Abstract: Compounds of formula I and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
Type:
Application
Filed:
June 3, 2022
Publication date:
November 7, 2024
Applicant:
VERTEX PHARMACEUTICALS INCORPORATED
Inventors:
Elizabeth Mary BECK, Robert PULLIN, Gorka ETXEBARRIA JARDI, Dean STAMOS, Yvonne SCHMIDT, Joseph PONTILLO, Stephen Andrew THOMSON, David Matthew SHAW, Nadia M. AHMAD, Lidio Marx CARVALHO MEIRELES, Sarah SKERRATT, Sara S. HADIDA RUAH, Mark Thomas Miller, Timothy Donald NEUBERT, Dennis James HURLEY, Jinglan ZHOU, Alexander KINTZER, Steven John DURRANT, Christopher WRAY, Anisa Nizarali VIRANI, Kiri NORTH, James DODD, Reece JACQUES, Stephen Michael GEDDIS, Bhairavi GALAN, Ronald Marcellus KNEGTEL, Ewa Iwona CHUDYK, Joanne Louise PINDER, Bruno Artur SOUSA, Rebecca E. STEVENS, Miranda Adele WRIGHT, Heather Clare TWIN, James Jun Bon MUI