Patents by Inventor Mircea C. Popescu

Mircea C. Popescu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5059591
    Abstract: Preparations of drugs in admixture with certain ligands are described which, when administered to animals or humans, are less toxic than conventional drug preparations. Although the toxicity of the drug-ligand preparations described is greatly reduced, the drug retains pharmacological activity.
    Type: Grant
    Filed: September 12, 1989
    Date of Patent: October 22, 1991
    Assignee: The Liposome Company, Inc.
    Inventors: Andrew S. Janoff, Mircea C. Popescu, Carl R. Alving, Michael W. Fountain, Robert P. Lenk, Marc J. Ostro, Paul A. Tremblay, Alan L. Weiner
  • Patent number: 5030453
    Abstract: A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the concentration of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.
    Type: Grant
    Filed: October 12, 1984
    Date of Patent: July 9, 1991
    Assignee: The Liposome Company, Inc.
    Inventors: Robert P. Lenk, Michael W. Fountain, Andrew S. Janoff, Mircea C. Popescu, Steven J. Weiss, Richard S. Ginsberg, Marc J. Ostro, Sol M. Gruner
  • Patent number: 5009819
    Abstract: A taste moderating composition comprising a liposome associated flavorant and method of preparation and use.
    Type: Grant
    Filed: November 12, 1987
    Date of Patent: April 23, 1991
    Assignee: The Liposome Company, Inc.
    Inventors: Mircea C. Popescu, Edgar T. Mertz
  • Patent number: 5000958
    Abstract: The invention encompasses mixtures of antimicrobial agents coencapsulated in liposomes which when administered in vivo exert an enhanced therapeutic effect. The therapeutic effectiveness of the coencapsulated antimocrobial agents is greater than that of the same combination administered either in solution or as a mixture of liposome populations each containing one of the antimicrobial agents.
    Type: Grant
    Filed: July 26, 1984
    Date of Patent: March 19, 1991
    Assignee: The Liposome Company, Inc.
    Inventors: Michael W. Fountain, Steven J. Weiss, Robert P. Lenk, Mircea C. Popescu, Richard S. Ginsberg
  • Patent number: 4897384
    Abstract: Preparations of drugs in admixture with certain ligands are described which, when administered to animals or humans, are less toxic than conventional drug preparations. Although the toxicity of the drug-ligand preparations described is greatly reduced, the drug retains pharmacological activity.
    Type: Grant
    Filed: March 24, 1986
    Date of Patent: January 30, 1990
    Assignee: The Liposome Company, Inc.
    Inventors: Andrew S. Janoff, Carl R. Alving, Michael W. Fountain, Robert P. Lenk, Marc J. Ostro, Mircea C. Popescu, Paul A. Tremblay, Alan L. Weiner
  • Patent number: 4891208
    Abstract: Steroidal liposomes comprising a bioactive agent and method for their administration are disclosed, the bilayers of said steroidal liposomes comprising a salt form of a carboxylic acid derivative of a sterol, a salt form of a polycarboxylic acid derivative of a sterol, a salt form of a hydroxy carboxylic acid derivative of a sterol, a salt form of an amino acid derivative of a sterol or a salt form of a poly (amino acid) derivative of a sterol; or a salt form of an organic acid derivative of cholesterol, a vitamin D, a phytosterol, or a steroidal hormone.
    Type: Grant
    Filed: September 10, 1985
    Date of Patent: January 2, 1990
    Assignee: The Liposome Company, Inc.
    Inventors: Andrew S. Janoff, Mircea C. Popescu, Alan L. Weiner, Lois E. Bolscak, Paul A. Tremblay, Christine E. Swenson
  • Patent number: 4721612
    Abstract: Methods and compositions are described for the preparation of lipid vesicles, the bilayers of which comprise a salt form of an organic acid derivative of a sterol such as the tris-salt form of a sterol hemisuccinate. The method is rapid, efficient, and does not require the use of organic solvents. The sterol hemisuccinate vesicles may be used to entrap compounds which are insoluble in aqueous solutions. Such preparations are especially useful for entrapping bioactive agents of limited solubility thus enabling administration in vivo.
    Type: Grant
    Filed: April 10, 1985
    Date of Patent: January 26, 1988
    Assignee: The Liposome Company, Inc.
    Inventors: Andrew S. Janoff, Mircea C. Popescu, Alan L. Weiner, Lois E. Bolcsak, Paul S. Tremblay
  • Patent number: 4708861
    Abstract: Compositions and methods for maintaining reservoirs of bioactive agents by sequestering the reservoir in a gel matrix are described. In particular, liposomes containing an entrapped bioactive agent are sequestered in a gel matrix. The resulting liposome-gel compositions may be used in vivo or in vitro to provide for sustained release of the bioactive agent. The gel matrix inhibits the dispersion and clearance of the sequestered liposomes without interfering with the ability of the liposomes to release the entrapped bioactive agent. Furthermore, the rate of release of the bioactive agent from the liposome-gel compositions may be varied by altering the composition of the liposomes and/or gels.
    Type: Grant
    Filed: January 31, 1985
    Date of Patent: November 24, 1987
    Assignee: The Liposome Company, Inc.
    Inventors: Mircea C. Popescu, Alan L. Weiner, Sharon S. Carpenter-Green
  • Patent number: 4610868
    Abstract: Lipid matrix carriers are described which provide for the sustained release of bioactive agents in vivo or in vitro. The properties of the lipid matrix carriers of the present invention include high entrapment efficiencies; release of entrapped compounds in their active form; biodegradability and avoidance of vascular occlusion in vivo; and avoidance of sequestration of the bioactive agent in the liver and spleen.
    Type: Grant
    Filed: March 20, 1984
    Date of Patent: September 9, 1986
    Assignee: The Liposome Company, Inc.
    Inventors: Michael W. Fountain, Steven J. Weiss, John J. Kearns, Alan L. Weiner, Mircea C. Popescu
  • Patent number: 4588578
    Abstract: A process for the preparation in a monophasic solvent system of a new type of lipid vesicles, called monophasic lipid vesicles (MPVs). MPVs can be made to encapsulate one or more bioactive agents. MPVs are stable during storage and can be used in vivo in the treatment of disease.
    Type: Grant
    Filed: August 8, 1983
    Date of Patent: May 13, 1986
    Assignee: The Liposome Company, Inc.
    Inventors: Michael W. Fountain, Steven J. Weiss, Mircea C. Popescu