Patents by Inventor Mirela O. Fagarasan

Mirela O. Fagarasan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating septic shock by preventing actin polymerization
    Patent number: 5593964
    Abstract: A method of treating septic shock in a mammal by preventing in vivo polymerization of actin in the mammal. An actin antipolymerizer such as thymosin .beta..sub.4 (T.beta..sub.4) is administered to the mammal so as to treat septic shock in the mammal. The amount of T.beta..sub.4 administered is sufficient to reduce levels of IL-1.alpha., TNF.alpha., PAF, Tx.beta..sub.2 and/or 6-keto-PGF.sub.1 .alpha. in the blood of the mammal. Also disclosed is a method of preventing septic shock in a mammal following endotoxin introduction in the mammal by administrating an actin antipolymerizer such as T.beta..sub.4.
    Type: Grant
    Filed: August 18, 1994
    Date of Patent: January 14, 1997
    Assignee: The George Washington University Medical Center
    Inventors: Allan L. Goldstein, Mirela O. Fagarasan
  • Method of treating septic shock using thymosin-.alpha. 1
    Patent number: 5585352
    Abstract: A method of reducing toxicity of endotoxin in a mammal including the administration of an endotoxin-reducing effective amount of T.alpha..sub.1 to the mammal.
    Type: Grant
    Filed: June 10, 1994
    Date of Patent: December 17, 1996
    Assignee: The George Washington University Medical Center
    Inventors: Allan J. Goldstein, Mirela O. Fagarasan
  • Method of treating septic shock using thymosin .beta..sub.4
    Patent number: 5578570
    Abstract: A method of treating septic shock in a mammal including the administration of a septic shock-treating effective amount of thymosin .beta..sub.4 (T.beta..sub.4) to the mammal. Included is a process directed to obstructing the progression of sepsis cascade by administration of a sepsis cascade progression-obstructing amount of T.beta..sub.4. Further included is a process directed to preventing septic shock by administration of a septic shock-preventing effective amount of T.beta..sub.4.
    Type: Grant
    Filed: June 10, 1994
    Date of Patent: November 26, 1996
    Assignee: The George Washington University Medical Center
    Inventors: Allan L. Goldstein, Mirela O. Fagarasan