Patents by Inventor Mirella Pilone

Mirella Pilone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MICROSENSOR FOR DETECTION OF D-AMINO-ACIDS
    Publication number: 20100163432
    Abstract: The instant invention is about a microelectrode, in particular for measuring the concentration of a D-amino acid, said microelectrode comprising means for oxidation of said D-amino acid into at least a compound B, means for optimising the detection of said compound B, and means for reducing interferences, in particular interferences due to the oxidation of other species than compound B; a device comprising such a microelectrode; a method for making such a microelectrode, a method for detecting and/or measuring the concentration of a D-amino-acid in a medium.
    Type: Application
    Filed: September 27, 2007
    Publication date: July 1, 2010
    Inventors: Stéphane Marinesco, Pierre Pernot, Jean-Pierre Mothet, Raymond Cespuglio, Oleg Scuvailo, Alexey Soldatkin, Loredano Pollegioni, Mirella Pilone
  • Cephalosporin C acylases
    Patent number: 7399624
    Abstract: Enzymes with cephalosporin C acylase activity obtained by site-directed, random or “site-saturation” mutagenesis of a native sequence optimised for expression in E. coli.
    Type: Grant
    Filed: January 11, 2005
    Date of Patent: July 15, 2008
    Assignee: Antibioticos S.p.A.
    Inventors: Loredano Pollegioni, Mirella Pilone, Gianluca Molla, Eugenio Cucchetti, Roberto Verga, Walter Cabri
  • Cephalosporin C acylases
    Publication number: 20050158818
    Abstract: Enzymes with cephalosporin C acylase activity obtained by site-directed, random or “site-saturation” mutagenesis of a native sequence optimised for expression in E. coli.
    Type: Application
    Filed: January 11, 2005
    Publication date: July 21, 2005
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Loredano Pollegioni, Mirella Pilone, Gianluca Molla, Eugenio Cucchetti, Roberto Verga, Walter Cabri
  • DNA fragment encoding D-amino acid oxidase
    Patent number: 5948660
    Abstract: The invention relates to a DNA fragment encoding the gene for D-amino acid oxidase, a method for the preparation of said fragment and the uses of the enzyme expressed by said fragment.
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: September 7, 1999
    Inventor: Mirella Pilone
  • Process for the enzymatic preparation of cephalosporanic derivatives using a D-amino acid oxidase from Rhodotorula glutinis NCIMB 40412
    Patent number: 5296358
    Abstract: The enzymatic preparation of cephalosporanic derivatives, or their salts, ving the formula: ##STR1## wherein R is --CO--COOH or --COOH, R.sub.1 is H, OH, or --O--CO--R" and R" is an alkyl group with 1 to 4 carbon atoms, is carried out by the oxidative deamination of compounds, or their salts, having the formula: ##STR2## with an oxidase D-Aminoacid enzyme derived from Rhodotorula glutinis NCIMB 40412. The enzyme can be in a free or immobilized form.
    Type: Grant
    Filed: June 3, 1992
    Date of Patent: March 22, 1994
    Assignee: Ministero Dell'Universita' e Della Ricerca Scientifica e Tecnologica
    Inventors: Ezio A. Battistel, Pietro Cesti, Giuliana Franzosi, Vilhelmus van der Goes, Silvana Bonicelli, Mirella Pilone