Abstract: A method of a radiotherapy or radiosurgery treatment comprises steps of: (a) providing a converging x-ray beam source configured for emitting a converging X-ray beam propagating along an axis thereof; (b) emitting the converging x-ray beam towards a volume of treatment (VOT) having a length along the axis of the converging X-ray beam ranging between 2 mm and 5 cm within a patient's body such that a waist portion is within the VOT; (c) propagating the beam through tissues previously located relative to the VOT (PO); the VOT per se and tissues distally located to the VOT (DO). The converging X-ray beam characterized by a convergent angle ranging between 2 and 30 degrees providing 80% to 100% of a maximum dose is received by the VOT and less than 60% of the maximum dose is received by the PO and the DO.

Abstract: The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, while the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.

Abstract: A standard of care protocol for increasing efficiency of a radiotherapy or radiosurgery treatment and reducing the treatment's side effects by radiating with a converging x-ray beam source emitting a converging x-ray beam (102) towards at least one volume of treatment (VOT) (103) within a patient's body; the beam is passing through at least one organ preceding said VOT (PO) (105) and at least one organ distal to said VOT (DO) (106); the VOT is receiving, on average, at least 80% of maximum dose whilst thr PO and DO are receiving, on average, no more than 40% of the maximum dose.

Abstract: An X-ray system for providing a converging X-rays comprising: (a) an X-ray source having an optical axis thereof; (b) an X-ray lens arrangement comprising at least one first ring having a first Bragg reflecting surface formed by a plurality of tiles made from single crystal. At least one ring is provided with at least one second ring mounted adjacently thereto along said optical axis in a coaxial manner; said second ring has a second Bragg reflecting surface reflecting surface thereof.

Abstract: The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, whilst the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.