Patents by Inventor Miriam Braunstein

Miriam Braunstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mycobacterial mutants affecting host apoptosis
    Patent number: 8394388
    Abstract: Provided are recombinant mycobacteria having a mutation in an nlaA gene or in a nuoG gene. Also provided are isolated and purified nlaA proteins and nuoG proteins from a mycobacterium. Additionally provided are isolated and purified nucleic acids comprising a recombinant nlaA gene or a recombinant nuoG gene. Further provided are methods of inducing an immune response in a mammal and methods of making a recombinant mycobacterium using the nlaA gene or the nuoG gene.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: March 12, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: William R. Jacobs, Jr., Steven A. Porcelli, Volker Briken, Miriam Braunstein
  • Mycobacterial SecA2 mutants
    Patent number: 8101191
    Abstract: Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a mutation in a SecA2 gene that eliminates SecA2 activity, where the mycobacteria are not Mycobacterium tuberculosis or Mycobacterium smegmatis. Additionally provided are methods of inducing an immune response in a mammal and methods of inducing an immune response to a pathogenic mycobacterium in a human using the above mycobacterial mutants.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: January 24, 2012
    Assignees: Albert Einstein College of Medicine of Yeshiva University, The University of North Carolina at Chapel Hill
    Inventors: William R. Jacobs, Jr., Steven A. Porcelli, Miriam Braunstein
  • MYCOBACTERIAL MUTANTS AFFECTING HOST APOPTOSIS
    Publication number: 20100297185
    Abstract: Provided are recombinant mycobacteria having a mutation in an nlaA gene or in a nuoG gene. Also provided are isolated and purified nlaA proteins and nuoG proteins from a mycobacterium. Additionally provided are isolated and purified nucleic acids comprising a recombinant nlaA gene or a recombinant nuoG gene. Further provided are methods of inducing an immune response in a mammal and methods of making a recombinant mycobacterium using the nlaA gene or the nuoG gene.
    Type: Application
    Filed: January 12, 2006
    Publication date: November 25, 2010
    Inventors: William R. Jacobs, JR., Steven A. Porcelli, Volker Briken, Miriam Braunstein
  • Mycobacterial SecA2 Mutants
    Publication number: 20090110696
    Abstract: Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a mutation in a SecA2 gene that eliminates SecA2 activity, where the mycobacteria are not Mycobacterium tuberculosis or Mycobacterium smegmatis. Additionally provided are methods of inducing an immune response in a mammal and methods of inducing an immune response to a pathogenic mycobacterium in a human using the above mycobacterial mutants.
    Type: Application
    Filed: January 11, 2007
    Publication date: April 30, 2009
    Inventors: William R. Jacobs, JR., Steven A. Porcelli, Miriam Braunstein